Abstract: The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination factors for carrying out DNA amplification assays. The present invention also features different recombinase ‘systems’ having distinct biochemical activities in DNA amplification assays, and differing requirements for loading factors, single-stranded DNA binding proteins (SSBs), and the quantity of crowding agent employed.

Abstract: A computer-implemented method including receiving, at a first device from a second device, a wireless beacon transmission; obtaining, by the first device from the wireless beacon transmission, an identifier for the second device; initiating, by the first device, a connection to the second device via a local area network using connection parameters determined based on the identifier; and establishing a pairing relationship between the first device and the second device based on the connection.

Abstract: Systems and methods are provided for pointing associated with datasets. One example method comprises loading data to a first dataset and accessing, by one or more objects of a platform, data from the first dataset, via a connector including an intermediate dataset and extraction, transformation, and load (ETL) process or a dataset view of the platform, where each of the ETL process and the dataset view includes a first dataset pointer specific to the first dataset. The example method also includes, in response to an update requirement: loading data, which is consistent with the update, to a duplicate dataset, and after the duplicate dataset is complete, changing the first dataset pointer in the ETL of the intermediate dataset or the dataset view, to a second dataset pointer specific to the duplicate dataset.

Abstract: A system delays input clock signals using time-to-digital converters (TDCs) to convert edges or the clock signals to digital values and storing the digital values in a memory. The digital values are retrieved from the memory based on a desired delay. A time counter used by the TDCs to determine the edges is also used determine the delay. The accuracy and range of the delay depends on the time counter and size of the memory.

Abstract: A surface cleaning head may include a fluid distributor configured to distribute a cleaning fluid, an agitator configured to absorb at least a portion of the distributed cleaning fluid and to agitate debris on the surface to be cleaned, a fluid stripper configured to remove, from the agitator, at least a portion of the distributed cleaning fluid absorbed by the agitator, a debris container, and a removable cover. The debris container may include a solid debris chamber and a fluid debris chamber. The removable cover may include a fluid catch plate configured to transfer at least a portion of the cleaning fluid removed from the agitator by the fluid stripper to the fluid debris chamber, the fluid catch plate being configured to selectively transition between an in-use position and a cleaning position when the removable cover is removed from the surface cleaning head.

Abstract: A scalable, real-time, label-free, electrode- or optical-based cell monitoring system for integration into a cell culture incubator is described herein. An example system includes (1) cell culture consumables with integrated electrodes and/or optics for growing and monitoring cells, (2) incubator trays for consumable organization and recording, and (3) a system console, external to the incubator, for connecting multiple incubator trays. Without perturbing the cell culture, the system is capable of monitoring multiple culture attributes for each cell culture consumable simultaneously. These attributes can include, but are not limited to, cell growth, proliferation, morphology, media pH, or media oxygen. The system can support multiple trays, which permits monitoring dozens to hundreds of consumables simultaneously, including a mixture of consumables of various sizes. In addition to monitoring adherent cells, the disclosed technology can be readily adapted for monitoring of cell suspensions.

Abstract: The disclosure relates to caninized chimeric anti-CD20 antibodies to the canine protein CD20 and methods of use to treat certain disorders such as non-Hoiodgkins B-cell lymphoma in dogs.

Abstract: A surgical clamp including a pair of jaws, which may be used to ablate or create lesions in tissue. In an exemplary embodiment, the jaws are movable between an articulated position in which the jaws are separated and not parallel to one another, an opened position in which the jaws are separated and substantially parallel to one another, and a closed position in which the jaws are adjacent and substantially parallel to one another.

Abstract: A cleaner assembly for an apparatus for making pouch products includes a cleaner roller and a poker roller. The cleaner roller may counter rotate with a rotatable drum of the apparatus, in contact with an upper surface of a first elastic layer on the rotatable drum, and at a greater tangential speed than at least one surface of an outer circumferential surface of the rotatable drum or an upper surface of the first elastic layer. The poker roller includes projections that are each configured to extend into one or more divots of the rotatable drum. The poker roller may counter rotate with the rotatable drum and at a same tangential speed as the at least one surface such that the projections extend into and out of separate, respective divots of the rotatable drum based on the counter rotation of the poker roller and the rotatable drum.

Abstract: At least one example embodiment relates to a container. The container includes a base, a canister configured to engage a portion of the base, and a lid configured to be removably coupled to the canister such that the lid is moveable between a locked position and an unlocked position. The base includes a bottom wall having a central portion, a peripheral portion, and an angle portion between the central portion and the peripheral portion. The base includes a first sidewall extending from a periphery of the peripheral portion and about a periphery of the bottom wall and a second sidewall extending from an end of the peripheral portion opposite the first sidewall. The first sidewall and the second sidewall extend perpendicular to the peripheral portion such that the peripheral portion, first sidewall, and second sidewall define a first gap.

Abstract: A disturb mitigation scheme is described for a 1TnC or multi-element ferroelectric gain bit-cell where after writing to a selected capacitor of the bit-cell, a cure phase is initiated. Between the cure phase and the write phase, there may be zero or more cycles where the selected word-line, bit-line, and plate-lines are pulled-down to ground. The cure phase may occur immediately before the write phase. In the cure phase, the word-line is asserted again just like in the write phase. In the cure phase, the voltage on bit-line is inverted compared to the voltage on the bit-line in the write phase. By programming a value in a selected capacitor to be opposite of the value written in the write phase of that selected capacitor, time accumulation of disturb is negated. This allows to substantially zero out disturb field on the unselected capacitors of the same bit-cell and/or other unselected bit-cells.

Abstract: A system includes a vehicle including a motive electrical power path; a power distribution unit including: a current protection circuit disposed in the motive electrical power path, the current protection circuit including a fuse and a contactor in a series arrangement with the fuse; a high voltage power input coupling including a first electrical interface for a high voltage power source; and a high voltage power output coupling including a second electrical interface for a motive power load, where the current protection circuit electrically couples the high voltage power input coupling to the high voltage power output coupling.

Abstract: An intraluminal device for delivering laser light and pressure waves includes a flexible elongate member positionable within a body lumen. The member includes an outer sheath; a laser catheter attached within the sheath; a sealed lens assembly located at the sheath's distal end; and a fluid chamber within the sheath, distal of the laser catheter and proximal of the lens assembly. The outer sheath includes a sealed acoustic window radially outward from the fluid chamber. When the chamber is filled with a fluid, a laser beam emitted by the laser catheter causes the photoreactive fluid to generate a pressure wave. When the chamber is filled with the fluid, a second laser beam emitted by the laser catheter exits via the transparent fluid and the sealed lens assembly. The sealed acoustic window and sealed lens assembly prevent the fluid from entering the body lumen.

Abstract: Systems and methods for collecting samples of production fluid from a wellbore are disclosed. In one example, a method for collecting samples of production fluid from a wellbore includes providing a fluid collector configured to selectively divert production fluid from a production flow line downstream of the wellbore to at least one sample container, and a controller configured to communicate with a computing device located remote from the fluid collector, and instructing the fluid collector to divert samples of production fluid to the at least one sample container according to a first sample collection schedule. The method also includes, during the first sample collection schedule, instructing the fluid collector, via the computing device located remote from the fluid collector, to divert samples of production fluid to the at least one sample container according to a second sample collection schedule.

Abstract: A system includes an intravascular reperfusion therapy device configured to be positioned within a coronary vein of a patient to deliver reperfusion therapy to a myocardium of a heart associated with the coronary vein. The intravascular reperfusion therapy device includes a sensor, a pump, and a catheter with a lumen. The intravascular reperfusion therapy device is configured to, using the pump, direct flow of a fluid through the lumen to deliver the reperfusion therapy. The system includes a processor circuit configured to receive, from the sensor, physiological data associated with blood flow through the coronary vein, determine, based on the physiological data, a progression of the reperfusion therapy; and control, based on the progression of the reperfusion therapy, the flow of the fluid through the lumen such that the reperfusion therapy is controlled.

Abstract: A vehicle and method of operating the vehicle that is operationally non-disruptive to one or more other rail vehicles or equipment of a railroad. The vehicle including a frame, drive wheels, and articulatable arms. The articulatable arms extend from the frame and supporting the drive wheels. The articulatable arms are selectively transitionable between first orientations and second orientations, and the drive wheels are engageable with rails that are configured to support the rail vehicle having wheel pairs. In the first orientations the drive wheels engage with the rails to support the frame, and in the second orientations the drive wheels disengage from the rails.

Abstract: A system to distinguish subtypes of cardiac amyloidosis includes a memory configured to store an echocardiographic image of at least a portion of a heart. The system also includes a processor operatively coupled to the memory. The processor is configured to analyze the echocardiographic image to identify a region of interest of the heart. The processor also determines a septal reflectivity ratio of the region of interest. The processor also determines, based at least in part on the septal reflectivity ratio, a subtype of cardiac amyloidosis present in the region of interest.

Abstract: A system for moving below a train, wagon or car, the system having a plurality of support elements each resting on one or the two rails, the support elements being retractable when a train wheel passes, so that the support elements sequentially retract to allow the wheel to pass the system.

Abstract: A processor comprises a computational array of computational elements and an instruction dispatch circuit. The computational elements receive data operands via data lanes extending along a first dimension, and processes the operands based upon instructions received from the instruction dispatch circuit via instruction lanes extending along a second dimension. The instruction dispatch circuit receives raw instructions, and comprises an instruction dispatch unit (IDU) processor that processes a set of raw instructions to generate processed instructions for dispatch to the computational elements, where the number of processed instructions is not equal to the number of instructions of the set of raw instructions.

Abstract: A device configured to generate haptic feedback is disclosed. The device includes a housing, a connector, and a haptic motor. The connector includes a mount end coupled to the housing and a distal end spaced away from the mount end. The haptic motor is coupled to the distal end of the connector. Activation of the haptic motor causes the haptic motor to move relative to the housing to generate the haptic feedback.