Abstract: Neurological diseases, including lysosomal storage diseases, can be successfully treated using intraventricular delivery of the therapeutic agents to bypass the blood-brain barrier. Similarly, diagnostic agents and anesthetic agents can be delivered to the brain in this manner. The administration can be performed slowly to achieve maximum effect. Such administration permits greater penetration of distal portions of the brain.

Abstract: This disclosure pertains to methods and compositions for tolerizing a mammal's brain to exogenously administered acid sphingomyelinase polypeptide by first delivering an effective amount of a transgene encoding the polypeptide to the mammal's hepatic tissue and then administering an effective amount of the transgene to the mammal's central nervous system (CNS).

Abstract: Amyotrophic Lateral Sclerosis can be successfully treated using intraventricular delivery of a neurotrophic growth factor, IGF-1. The administration can be performed slowly to achieve maximum effect. Effects are seen on both sides of the blood-brain barrier, making this a delivery means for Amyotrophic Lateral Sclerosis which affects both brain and skeletal muscle.

Abstract: This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention provides a method to deliver a transgene to a subject's spinal cord by administering a recombinant neurotropic viral vector containing the transgene. The viral vector delivers the transgene to a region of the deep cerebellar nuclei region of the brain. Also provided are compositions and methods to deliver a transgene to a subject's spinal cord by administering a recombinant neurotropic viral vector containing the transgene to the motor cortex region of the subject's brain.

Abstract: The disclosure pertains to methods and compositions for treating disorders affecting the central nervous system (CNS). These disorders include neurometabolic disorders such as lysosomal storage diseases that affect the central nervous system, e.g., Niemann-Pick A disease. They also include disorders such as Alzheimer's disease. The disclosed methods involve contacting an axonal ending of a neuron with a composition containing high titer AAV carrying a therapeutic transgene so that the AAV vector is axonally transported in a retrograde fashion and transgene product is expressed distally to the administration site.

Abstract: Systems, methods and apparatus are provided through which in some embodiments, a wrap-around capture device of an X-ray collimator frame limits movement of an X-ray tube mounting bracket away from the X-ray collimator. In some embodiments, a C-shaped passive capture device is attached or mounted on the wrap-around capture device, having a portion that is positioned in between the wrap-around capture device and the X-ray collimator frame, which further limits movement of the X-ray tube mounting bracket.

Abstract: The disclosure pertains to methods for treating neurometabolic disorder including lysosomal storage diseases that affect the central nervous system, e.g., Niemann-Pick A disease. The disclosed methods involve contacting an axonal ending of a neuron with a composition containing high titer AAV carrying a therapeutic transgene so that the AAV vector is axonally transported in a retrograde fashion and transgene product is expressed distally to the administration site.

Abstract: A system and method for translating a patient table is described. The described patient table includes a linearly translatable portion, a drive screw assembly, a power transmission assembly, and a drive train. The translatable portion is configured to be positioned in a plurality of selectable positions between a fully inserted position and a fully extracted position. The drive screw assembly includes a drive nut and a screw member. The drive nut is fixedly coupled to the translatable portion of the patient table and threadily engaged to the screw member. The screw member is drivingly coupled to the power transmission assembly. The drive train is configured to drive the translatable portion of the patient table at a predetermined insertion force in the insertion direction, and a predetermined extraction force in the extraction direction. The predetermined extraction force is greater than the predetermined insertion force.