Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to delver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.

Abstract: A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.

Abstract: A turbine engine component, such as a turbine blade, has an airfoil portion, a plurality of cooling passages within the airfoil portion with each of the cooling passages having an inlet for a cooling fluid. Each inlet has a flared bellmouth inlet portion. The turbine engine component may further have a dirt funnel at the tip of the airfoil portion, a platform with at least one beveled edge, and an undercut trailing edge slot.

Abstract: A wheel suspension assembly for a vehicle is operable to travel across a ground surface. The wheel suspension assembly includes a first suspension member, a second suspension member, a wheel rotatably coupled to the first suspension member and a ball stud interconnecting the first and second suspension members. The ball stud includes a ball and a tapered shaft. The tapered shaft extends along a longitudinal axis. One of the first and second suspension members includes a ball socket in receipt of the ball. The other of the first and second suspension members includes a tapered bore in the receipt of the tapered shaft. The longitudinal axis of the tapered shaft is oriented substantially parallel to the ground surface.

Abstract: A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.

Abstract: A blade used in a gas turbine engine in which the blade is formed of a blade portion made from a metallic material, and a tip portion made of a ceramic material, the tip portion forming at least 10% of the overall blade length such that the blade is lighter than a all-metallic blade. The ceramic tip of the blade allows the blade to withstand higher temperature environments without damaging the blade as would occur in an all-metallic blade.

Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.

Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.

Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.

Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.

Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.

Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.

Abstract: A blade used in a gas turbine engine in which the blade is formed of a blade portion made from a metallic material, and a tip portion made of a ceramic material, the tip portion forming at least 10% of the overall blade length such that the blade is lighter than a all-metallic blade. The ceramic tip of the blade allows the blade to withstand higher temperature environments without damaging the blade as would occur in an all-metallic blade.

Abstract: A suspension module with a suspension component, wheel hubs coupled to the suspension component, and a drive system. The drive system has a pair of units that selectively provide drive torque to an associated one of the wheel hubs. Each unit includes a motor, a first reduction gearset and an overrunning clutch. The first reduction gearset is disposed between the motor and its wheel hub and multiplies torque output from the motor. The clutch disconnects the motor from the associated wheel hub so that an output shaft of the motor is not drivingly coupled to the associated wheel hub when a rotational speed of the first portion does not exceed a rotational speed of the second portion. The clutch can be selectively operated to drivingly couple the motor to its wheel hub to permit the motor to be back-driven. A method for operating a hybrid power train is also provided.

Abstract: A wheel suspension assembly for a vehicle is operable to travel across a ground surface. The wheel suspension assembly includes a first suspension member, a second suspension member, a wheel rotatably coupled to the first suspension member and a ball stud interconnecting the first and second suspension members. The ball stud includes a ball and a tapered shaft. The tapered shaft extends along a longitudinal axis. One of the first and second suspension members includes a ball socket in receipt of the ball. The other of the first and second suspension members includes a tapered bore in the receipt of the tapered shaft. The longitudinal axis of the tapered shaft is oriented substantially parallel to the ground surface.

Abstract: A turbine engine component, such as a turbine blade, has an airfoil portion, a plurality of cooling passages within the airfoil portion with each of the cooling passages having an inlet for a cooling fluid. Each inlet has a flared bellmouth inlet portion. The turbine engine component may further have a dirt funnel at the tip of the airfoil portion, a platform with at least one beveled edge, and an undercut trailing edge slot.