Abstract: A drive train for a vehicle having an axle and a multi-speed drive unit. The axle includes a housing and a differential with an input pinion. The drive unit includes a planetary transmission, a drive unit housing and a dog clutch that is employed to selectively operate the planetary transmission in different speed ratios.

Abstract: A wheel suspension assembly for a vehicle is operable to travel across a ground surface. The wheel suspension assembly includes a first suspension member, a second suspension member, a wheel rotatably coupled to the first suspension member and a ball stud interconnecting the first and second suspension members. The ball stud includes a ball and a tapered shaft. The tapered shaft extends along a longitudinal axis. One of the first and second suspension members includes a ball socket in receipt of the ball. The other of the first and second suspension members includes a tapered bore in the receipt of the tapered shaft. The longitudinal axis of the tapered shaft is oriented substantially parallel to the ground surface.

Abstract: A die for forming a lost wax ceramic core allows the formation of non-parallel separating spaces between adjacent portions of the core. The core will eventually form cooling channels in an airfoil. The die for forming the core includes a plurality of moving parts having rib extensions. At least some rib extensions are non-parallel to form the non-parallel spaces. The die includes two main die halves that come together to form several of the spaces. Inserts move with those die components and come together to form other spaces. At least one of the inserts contacts surfaces on one of the die halves, such that the non-parallel spaces are formed.

Abstract: A turbine blade system for a gas turbine engine includes a turbine blade having a trailing edge region extending in a lateral direction and in a lengthwise direction from a pressure side surface to a trailing edge. The trailing edge region includes a plurality of riblets extending in the lengthwise direction from the pressure side surface toward the trailing edge. The trailing edge region defines a plurality of ejection slots each laterally disposed between two of the riblets. The plurality of riblets each define an upper surface having at least a portion in the lengthwise direction being curved relative to the pressure side surface so as to generally shield the upper surface from a high heat load propagating from the pressure side surface and to facilitate cooling air flowing from the ejection slots to flow over the upper surface.

Abstract: A turbine blade cooling system for a gas turbine engine includes a turbine blade having a trailing edge, a concave side, and a convex side. The trailing edge defines at least one set of impingement holes each having a central longitudinal axis which is closer to a nearest portion of an edge of the blade at one of the concave and convex sides relative to a nearest portion of an edge of the blade at the other of the concave and convex sides. Alternatively or in addition to the foregoing, the trailing edge can define at least one set of impingement holes each having a central longitudinal axis which is angled in a direction of a flow of cooling medium toward one of the concave and convex sides relative to the other of the concave and convex sides.

Abstract: A propeller shaft assembly includes a substantially cylindrical hollow propeller shaft, a stub shaft and a constant velocity joint having inner race and an outer race drivingly interconnected by a plurality of balls. The stub shaft has a first end fixed to the propeller shaft and a second end drivingly coupled to the inner race. The second end includes a portion positioned adjacent to the inner race that defines an outer diameter greater than an outer diameter defined by the interface between the inner race and the plurality of balls.

Abstract: A wheel suspension assembly for a vehicle is operable to travel across a ground surface. The wheel suspension assembly includes a first suspension member, a second suspension member, a wheel rotatably coupled to the first suspension member and a ball stud interconnecting the first and second suspension members. The ball stud includes a ball and a tapered shaft. The tapered shaft extends along a longitudinal axis. One of the first and second suspension members includes a ball socket in receipt of the ball. The other of the first and second suspension members includes a tapered bore in the receipt of the tapered shaft. The longitudinal axis of the tapered shaft is oriented substantially parallel to the ground surface.

Abstract: A method and system for providing configurable features for a multi-windowed graphical user interface (GUI) for electronic trading. The configurable features include, but are not limited to, creating collective windows comprising plural individual windows, where the collective window functions like an individual window, collapsing plural windows with a single action and changing display characteristics of the plural windows or the collective windows. The method and system allows a user of a target device to customize the multi-windowed GUI based on individual user preferences for electronic trading.

Abstract: A two speed drive system for an all wheel drive vehicle includes a double planetary gear front differential and a power take-off unit transferring drive torque to a front wheel set and a rear wheel set of the vehicle. A rear differential connects the power take-off unit and the rear wheel set providing the drive torque to the rear wheel set. A two speed drive unit is positioned between the power take-off unit and the rear differential. The drive unit shifts between a high range drive operation and a low range drive operation. The drive unit may be mounted directly to either the power take-off unit or the rear differential.

Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: The present invention relates to methods and devices for administration of substances into the intradermal layer of skin.

Abstract: A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.

Abstract: A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.

Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.

Abstract: Methods and devices for administration of substances into the intradermal layer of skin with improved bioavailability.

Abstract: A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.

Abstract: A process for lysing Mycobacteria to liberate nucleic acids such as DNA and RNA comprises heating the Mycobacteria in an aqueous solution to lyse the Mycobacteria and release the nucleic acids, with the aqueous solution containing a chelating agent such as EDTA or EGTA in an amount effective to inhibit degradation of the released nucleic acids. Examples of Mycobacteria which can be lysed include Mycobacterium fortuitum and Mycobacterium tuberculosis. After lysis, the nucleic acid is preferably then amplified and detected. Kits useful for carrying out the present invention are also disclosed.

Abstract: A process for lysing Mycobacteria to liberate nucleic acids such as DNA and RNA comprises heating the Mycobacteria in an aqueous solution to lyse the Mycobacteria and release the nucleic acids, with the aqueous solution containing a chelating agent such as EDTA or EGTA in an amount effective to inhibit degradation of the released nucleic acids. Examples of Mycobacteria which can be lysed include Mycobacterium fortuitum and Mycobacterium tuberculosis. After lysis, the nucleic acid is preferably then amplified and detected. Kits useful for carrying out the present invention are also disclosed.