Abstract: There is provided a process for the production a compound of general formula I: wherein A, R1, R2, R3 and R4 have meanings given in the description, which process comprises the reaction of a compound of formula II, wherein Rx is a group substitutable by an aminopyrazole, with a compound of general formula III

Abstract: The present invention is directed to a a method for the treatment of irritable bowel syndrome comprising the multiple daily pulse dosing of an immediate release formulation of the anti-muscarinic darifenacin. Dosing two or three times a day is particularly preferred.

Abstract: A stable solid hydrate of a muscarinic receptor antagonist is useful in the treatment of irritable bowel syndrome, diverticular disease, oesophageal achalasia, chronic obstructive airways disease, over active bladder (including symptoms of incontinence, urge and frequency), urinary incontinence, neurogenic urinary urgency or pollakiuria, treatment of bladder functional disorder, urinary leakage, painful or difficult urination caused by neurogenic bladder, spastic or hypertonic bladder, dysfunctional bladder syndrome, gastrointestinal disorders including gastrointestinal hyperactivity, and relaxing effect on intestinal smooth muscle cells.

Abstract: Intranasal formulations of sildenafil mesylate for the treatment of male erectile dysfunction or female sexual disorders.

Abstract: The present invention is directed to a a method for the treatment of irritable bowel syndrome comprising the multiple daily pulse dosing of an immediate release formulation of the anti-muscarinic darifenacin. Dosing two or three times a day is particularly preferred.

Abstract: A process is provided for the preparation of a compound of formulae (IA) (sidenafil) and (IB) 1

Abstract: The invention relates to a device for managing battery packs by measuring and monitoring the operating capacity of individual battery modules in a battery pack. A programmable logic controller directs the selective closing of relays to allow individual battery modules to be load-tested using a variable discharge load unit, without compromising useful battery pack capacity. A battery module whose useful capacity falls below a predefined threshold may be connected to a battery charger for replenishment and then electrically realigned with the remaining modules in the pack for continued operation. Alternatively, an alarm may be triggered which alerts the user that the module is due for replacement. This sequence of events is performed on all cells in the pack at a predetermined interval.

Abstract: An apparatus and method for detecting speed variations across a die, a flash field, i.e., multiple dies, and multiple flash fields. In one embodiment, a method comprises the step of inserting a plurality of functional circuits at strategic locations across a die or flash field or multiple flash fields where each of the plurality of functional circuits generates data, e.g., values, frequency, etc., correlated to the die speeds at the strategic locations. The method further comprises reading the data generated by the plurality of functional circuits that may be correlated to the die speeds at the strategic locations. Speed variations across the die or flash field or multiple flash fields may then be subsequently detected based on the data generated by the plurality of functional circuits. Upon analyzing the data generated by the plurality of functional circuits, adjustments may be made to the manufacturing process to improve the number of acceptable integrated circuits or chips disposed in the dies.

Abstract: A self-contained, battery powered, on board auxiliary starting device provides high DC power levels for short durations for starting engines. Preferred devices have a battery, a connector terminal assembly, and a monitor/control circuit that controls the charging and use of the auxiliary battery, and limits the device output to safe voltage levels so the auxiliary battery is not damaged due to overdischarge. The connector terminal assembly preferably has 2 or more contacts, sized and dimensioned to electrically contact (mate) with selected electric power harnesses selected to connect to and provide auxiliary power to augment standard batteries. In another aspect of preferred embodiments, the coupling mechanism and mounting bracket allow the battery to be quickly removed from the principal mounting bracket and quickly installed on another engine or be connected to a special set of mating cables with clamps for attachment across another battery for augmenting its power.

Abstract: Intranasal formulations of sildenafil mesylate for the treatment of male erectile dysfunction or female sexual disorders.

Abstract: There is provided a process for the production a compound of general formula I: 1

Abstract: A vehicle power and starter system for use in operating a motor vehicle has a first battery that is electrically coupled to a starter and a plurality of electric loads, and a second battery that is electrically coupled to the starter and electrically isolated from the electric loads in the vehicle, wherein both the first and the second batteries are charged by the power source.

Abstract: A process is provided for the preparation of a compound of formulae (IA) (sidenafil) and (IB) 1

Abstract: A method of reducing the formation of silicon crystal defects due to extrinsic stresses in an integrated circuit chip. The source of such extrinsic stresses may be filling trenches with polycrystalline silicon or oxide, silicides, forming silicon nitride spacers or liners, or during oxide birds-beak formation, or at numerous other processing points. At an appropriate point, as each sensitive feature is defined or formed, carbon co-implanted into the silicon wafer at or near the feature.

Abstract: A process is provided for the preparation of a compound of formulae (IA) (sidenafil) and (IB) comprising reacting a compound of formula (IIA) and (IIB) respectively in the presence of —OR, wherein R in the case of formation of compound (IA) is CH2CH3 and R in the case of formation of compound (IB) is CH2CH2CH3, where X is a leaving group:

Abstract: The present invention relates to a crystalline, &agr;-polymorphic form of a compound of formula (I) and to processes for the preparation of, to intermediates used in the preparation of, to compositions containing and to uses of, the &agr;-polymorphic form.

Abstract: A process for the preparation of a compound of formula (I): ##STR1## which comprises cyclization of a compound of formula (II): ##STR2##

Abstract: This invention relates to a novel Eimeria protein with immunogenic properties as well as to DNA sequences encoding these proteins. This protein can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding this protein can be used for the preparation of a vector vaccine against coccidiosis.

Abstract: A process for the preparation of a compound of formula (I): ##STR1## which comprises cyclization of a compound of formula (II): ##STR2##

Abstract: A method for maintaining hepatocytes in culture includes providing the hepatocytes with a support, the support including extracellular matrix, the support having a configuration that permits each of at least a portion of the hepatpocytes to form at least one apical surface and at least two discrete basal surfaces.