Patents by Inventor James E. Crowe, Jr.

James E. Crowe, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12233127
    Abstract: The present disclosure is directed to antibodies binding previously undefined epitopes on influenza A virus hemagglutinin and methods for use thereof.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: February 25, 2025
    Assignee: Vanderbilt University
    Inventor: James E. Crowe, Jr.
  • Patent number: 12216120
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: February 4, 2025
    Assignee: Vanderbilt University
    Inventors: James E. Crowe, Jr., Seth Zost, Robert Carnahan, Pavlo Gilchuk
  • Patent number: 12188053
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing norovirus and methods for use thereof. Thus, in accordance with the present disclosure, there is provided a method of detecting a norovirus infection in a subject comprising (a) contacting a sample from the subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences; and (b) detecting norovirus in the sample by binding of the antibody or antibody fragment to a norovirus antigen in the sample.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: January 7, 2025
    Assignees: VANDERBILT UNIVERSITY, BAYLOR COLLEGE OF MEDICINE
    Inventors: James E. Crowe, Jr., Mary Estes
  • Publication number: 20240288426
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Crimean Congo Hemorrhagic Fever Virus and methods for use thereof.
    Type: Application
    Filed: January 11, 2021
    Publication date: August 29, 2024
    Applicant: Vanderbilt University
    Inventor: James E. CROWE, Jr.
  • Publication number: 20240287160
    Abstract: The present disclosure is directed to an antibody cocktail comprising antibodies that bind to and protect subjects again multiple ebolavirus strains and methods for use thereof.
    Type: Application
    Filed: April 20, 2022
    Publication date: August 29, 2024
    Inventors: James E. CROWE, Jr., Pavlo GILCHUK
  • Patent number: 12037384
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Yellow Fever Virus and methods for use thereof.
    Type: Grant
    Filed: July 29, 2022
    Date of Patent: July 16, 2024
    Assignee: VANDERBILT UNIVERSITY
    Inventor: James E. Crowe, Jr.
  • Patent number: 12024555
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing West Nile virus and methods for use thereof.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: July 2, 2024
    Assignee: VANDERBILT UNIVERSITY
    Inventor: James E. Crowe, Jr.
  • Patent number: 11992520
    Abstract: The present disclosure is directed to antibodies binding to and inhibiting S. aureus and methods for use thereof.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: May 28, 2024
    Assignee: VANDERBILT UNIVERSITY
    Inventors: James E. Crowe, Jr., Eric Skaar
  • Patent number: 11957745
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Japanese Encephalitis virus and methods for use thereof.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: April 16, 2024
    Assignee: VANDERBILT UNIVERSITY
    Inventor: James E. Crowe, Jr.
  • Patent number: 11939370
    Abstract: The present disclosure is directed to human antibodies binding to and neutralizing ebolavirus and methods for use thereof. A further embodiment involves a monoclonal antibody, wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences. In yet another embodiment, there is provided a hybridoma or engineered cell encoding an antibody or antibody fragment. An additional embodiment comprises a vaccine formulation comprising one or more antibodies or antibody fragments characterized by clone-paired heavy and light chain CDR sequences. In still a further embodiment, there is provided a method of protecting the health of a placenta and/or fetus of a pregnant a subject infected with or at risk of infection with ebolavirus comprising delivering to said subject the antibody or antibody fragment.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: March 26, 2024
    Assignees: VANDERBILT UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: James E. Crowe, Jr., Pavlo Gilchuk, Alexander Bukreyev
  • Patent number: 11851478
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: December 26, 2023
    Assignee: VANDERBILT UNIVERSITY
    Inventor: James E Crowe, Jr.
  • Publication number: 20230365658
    Abstract: Provided herein are novel monoclonal antibodies and antibody fragments with improved binding to and/or neutralization against multiple SARS-CoV-2 variants, e.g., Omicron lineages. Also provided are compositions and biosensors comprising the monoclonal antibodies and antibody fragments and methods of using the novel monoclonal antibodies and antibody fragments for treating, preventing, and diagnosing COVID-19 and detecting SARS-CoV-2.
    Type: Application
    Filed: March 16, 2023
    Publication date: November 16, 2023
    Inventors: Edmond Y. Lau, Daniel M. Faissol, Thomas Anthony Desautels, Fangqiang Zhu, Adam T. Zemla, Robert Herschel Carnahan, JR., Antonietta Maria Lillo, James E. Crowe, JR., Kathryn Arrildt
  • Publication number: 20230348571
    Abstract: The present disclosure relates to antibodies and uses thereof for treating, preventing, and detecting coronavirus infection.
    Type: Application
    Filed: April 6, 2021
    Publication date: November 2, 2023
    Inventors: Ivelin Stefanov Georgiev, Andrea R. Shiakolas, Kevin J. Kramer, James E. Crowe, Jr., Robert Carnahan, Nianshuang Wang, Daniel Wrapp, Jason McLellan
  • Patent number: 11802146
    Abstract: This disclosure relates to compositions and methods for treating and preventing chikungunya virus infection by delivering polynucleotides encoding anti-chikungunya virus antibodies to a subject. Compositions and treatments provided herein include one or more polynucleotides having an open reading frame encoding an anti-chikungunya virus antibody heavy chain or fragment thereof and/or an anti-chikungunya virus antibody light chain or fragment thereof. Methods for preparing and using such treatments are also provided.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: October 31, 2023
    Assignees: ModernaTX, Inc., Vanderbilt University
    Inventors: Sunny Himansu, James E. Crowe, Jr., Giuseppe Ciaramella
  • Patent number: 11692023
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: July 4, 2023
    Assignee: VANDERBILT UNIVERSITY
    Inventor: James E. Crowe, Jr.
  • Publication number: 20230181714
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Venezuelan Equine Encephalitis Vims (VEEV) and methods for use thereof.
    Type: Application
    Filed: May 27, 2021
    Publication date: June 15, 2023
    Inventor: James E. CROWE, Jr.
  • Patent number: 11667697
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Poxvirus and methods for use thereof.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: June 6, 2023
    Assignee: VANDERBILT UNIVERSITY
    Inventors: James E. Crowe, Jr., Iuliia Gilchuk
  • Publication number: 20230122364
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing tire coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: March 26, 2021
    Publication date: April 20, 2023
    Inventors: James E. CROWE, Jr., Seth ZOST, Robert CARNAHAN, Pavlo GILCHUK
  • Publication number: 20230085393
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Zika vims and methods for use thereof.
    Type: Application
    Filed: November 9, 2020
    Publication date: March 16, 2023
    Applicant: Vanderbilt University
    Inventors: James E. Crowe, Jr., Robert H. Carnanhan, Pavlo Gilchuk
  • Publication number: 20230078330
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing dengue virus and methods for use thereof.
    Type: Application
    Filed: January 19, 2021
    Publication date: March 16, 2023
    Inventors: James E. CROWE, JR., Ralph BARIC, Eva HARRIS