Patents by Inventor James E. Crowe, Jr.

James E. Crowe, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210300999
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: March 25, 2021
    Publication date: September 30, 2021
    Applicant: Vanderbilt University
    Inventors: James E. CROWE, JR., Seth ZOST, Robert CARNAHAN, Pavlo GILCHUK
  • Publication number: 20210277092
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: February 11, 2021
    Publication date: September 9, 2021
    Applicant: Vanderbilt University
    Inventors: James E. Crowe, JR., Seth Zost, Robert Carnahan, Pavlo Gilchuk
  • Publication number: 20210252150
    Abstract: The present disclosure is directed to antibodies binding previously undefined epitopes on influenza A virus hemagglutinin and methods for use thereof.
    Type: Application
    Filed: August 22, 2019
    Publication date: August 19, 2021
    Inventor: James E. Crowe, Jr.
  • Patent number: 11084869
    Abstract: The present disclosure is directed to antibodies binding to Marburg virus (MARV) glycoprotein (GP) and methods of use therefore.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: August 10, 2021
    Assignees: VANDERBILT UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: James E. Crowe, Jr., Andrew I. Flyak, Alexander Bukreyev, Philipp Ilinykh
  • Patent number: 11054423
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing ebolavirus and methods for use thereof. The present disclosure is directed to a method of detecting an ebolavirus infection in a subject comprising (a) contacting a sample from said subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Table 2, or an antibody fragment thereof; and (b) detecting ebolavirus glycoprotein in said sample by binding of said antibody or antibody fragment to antigen in said sample. In still further embodiments, the present disclosure concerns immunodetection kits for use with the iminunodetection methods described above.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: July 6, 2021
    Assignees: VANDERBILT UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: James E. Crowe, Jr., Andrew I. Flyak, Alexander Bukreyev, Philipp Ilinykh
  • Patent number: 11021533
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: June 1, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventor: James E. Crowe, Jr.
  • Publication number: 20210115115
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing West Nile virus and methods for use thereof.
    Type: Application
    Filed: March 26, 2019
    Publication date: April 22, 2021
    Applicant: Vanderbilt University
    Inventor: James E. Crowe, Jr.
  • Patent number: 10981979
    Abstract: The present disclosure is directed to antibodies binding to prefusion and postfusion forms of both human S. aureus and human metapneumovirus F proteins, including neutralizing antibodies, and methods for use thereof.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: April 20, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: James E. Crowe, Jr., Gopal Sapparapu, Isaac Thomsen, Buddy Creech
  • Publication number: 20210009662
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
    Type: Application
    Filed: January 4, 2019
    Publication date: January 14, 2021
    Inventor: James E Crowe, JR.
  • Publication number: 20200390879
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Japanese Encephalitis virus and methods for use thereof.
    Type: Application
    Filed: February 22, 2019
    Publication date: December 17, 2020
    Applicant: Vanderbilt University
    Inventor: James E. Crowe, Jr.
  • Publication number: 20200369748
    Abstract: This disclosure relates to compositions and methods for treating and preventing chikungunya virus infection by delivering polynucleotides encoding anti-chikungunya virus antibodies to a subject. Compositions and treatments provided herein include one or more polynucleotides having an open reading frame encoding an anti-chikungunya virus antibody heavy chain or fragment thereof and/or an anti-chikungunya virus antibody light chain or fragment thereof. Methods for preparing and using such treatments are also provided.
    Type: Application
    Filed: January 4, 2019
    Publication date: November 26, 2020
    Inventors: Sunny Himansu, James E. Crowe, Jr., Giuseppe Ciaramella
  • Patent number: 10787503
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: September 29, 2020
    Assignee: VANDERBILT UNIVERSITY
    Inventors: James E. Crowe, Jr., Scott A. Smith, Terence Dermody, Laurie Silva
  • Publication number: 20200277359
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
    Type: Application
    Filed: October 10, 2019
    Publication date: September 3, 2020
    Inventors: James E. CROWE, Jr., Scott A. SMITH, Terence DERMODY, Laurie SILVA
  • Publication number: 20200200749
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing ebolavirus and methods for use thereof. The present disclosure is directed to a method of detecting an ebolavirus infection in a subject comprising (a) contacting a sample from said subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Table 2, or an antibody fragment thereof; and (b) detecting ebolavirus glycoprotein in said sample by binding of said antibody or antibody fragment to antigen in said sample. In still further embodiments, the present disclosure concerns immunodetection kits for use with the iminunodetection methods described above.
    Type: Application
    Filed: February 13, 2020
    Publication date: June 25, 2020
    Inventors: James E. CROWE, Jr., Andrew I. FLYAK, Alexander BUKREYEV, Philipp ILINYKH
  • Publication number: 20200188504
    Abstract: The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Applicants: Vanderbilt University, The Trustees of the University of Pennsylvania, The John Hopkins University
    Inventors: James E. CROWE, JR., Andrew FLYAK, Justin BAILEY, Stuart RAY, George SHAW
  • Patent number: 10620204
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing ebolavirus and methods for use thereof. The present disclosure is directed to a method of detecting an ebolavirus infection in a subject comprising (a) contacting a sample from said subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Table 2, or an antibody fragment thereof; and (b) detecting ebolavirus glycoprotein in said sample by binding of said antibody or antibody fragment to antigen in said sample. In still further embodiments, the present disclosure concerns immunodetection kits for use with the immunodetection methods described above.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: April 14, 2020
    Assignees: VANDERBILT UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: James E. Crowe, Jr., Andrew I. Flyak, Alexander Bukreyev, Philipp Ilinykh
  • Publication number: 20200071389
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Poxvirus and methods for use thereof.
    Type: Application
    Filed: October 18, 2017
    Publication date: March 5, 2020
    Applicant: Vanderbilt University
    Inventors: James E. CROWE, Jr., Iuliia GILCHUK
  • Publication number: 20200040066
    Abstract: The present disclosure is directed to antibodies binding to Marburg virus (MARV) glycoprotein (GP) and methods of use therefore.
    Type: Application
    Filed: October 15, 2019
    Publication date: February 6, 2020
    Inventors: James E. CROWE, Jr., Andrew I. FLYAK, Alexander BUKREYEV, Philipp ILINYKH
  • Publication number: 20200010536
    Abstract: The present disclosure is directed to antibodies binding to prefusion and postfusion forms of both human S. aureus and human metapneumovirus F proteins, including neutralizing antibodies, and methods for use thereof.
    Type: Application
    Filed: March 6, 2018
    Publication date: January 9, 2020
    Applicant: Vanderbilt University
    Inventors: James E. CROWE, Jr., Gopal SAPPARAPU, Isaac THOMSEN, Buddy CREECH
  • Publication number: 20190367586
    Abstract: The present disclosure is directed to antibodies binding to human respiratory syncytial virus F protein, including both neutralizing and non-neutralizing antibodies, and methods for use thereof.
    Type: Application
    Filed: December 18, 2017
    Publication date: December 5, 2019
    Applicant: Vanderbilt University
    Inventors: James E. Crowe, JR., Jarrod Mousa