Patents by Inventor James E. Crowe, Jr.

James E. Crowe, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN MONOCLONAL ANTIBODIES TO HANTAVIRUS AND METHODS OF USE THEREFORE
    Publication number: 20220380442
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing hantavirus and methods for use thereof.
    Type: Application
    Filed: November 10, 2020
    Publication date: December 1, 2022
    Applicant: Vanderbilt University
    Inventor: James E. CROWE, Jr.
  • HUMAN MONOCLONAL ANTIBODIES TO ENTEROVIRUS D68
    Publication number: 20220289828
    Abstract: The present disclosure is directed to antibodies binding to enterovirus D68 (EV-D68) and methods for use thereof.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 15, 2022
    Inventors: JAMES E. CROWE, Jr., MATTHEW R. VOGT
  • HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2)
    Publication number: 20220281958
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: March 18, 2022
    Publication date: September 8, 2022
    Applicant: Vanderbilt University
    Inventors: James E. CROWE, JR., Seth ZOST, Robert CARNAHAN, Pavlo GILCHUK
  • Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
    Patent number: 11345741
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: May 31, 2022
    Assignee: Vanderbilt University
    Inventors: James E. Crowe, Jr., Seth Zost, Robert Carnahan, Pavlo Gilchuk
  • Antibody-mediated neutralization of chikungunya virus
    Patent number: 11345743
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: May 31, 2022
    Assignee: VANDERBILT UNIVERSITY
    Inventors: James E. Crowe, Jr., Scott A. Smith, Terence Dermody, Laurie Silva
  • HUMAN MONOCLONAL ANTIBODIES TO STAPHYLOCOCCAL AUREUS ISD PROTEINS AND USES THEREOF
    Publication number: 20220080036
    Abstract: The present disclosure is directed to antibodies binding to and inhibiting S. aureus and methods for use thereof.
    Type: Application
    Filed: September 6, 2019
    Publication date: March 17, 2022
    Inventors: James E. Crowe, Jr., Eric Skaar
  • PAN-EBOLAVIRUS NEUTRALIZING HUMAN ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20210403538
    Abstract: The present disclosure is directed to human antibodies binding to and neutralizing ebolavirus and methods for use thereof. A further embodiment involves a monoclonal antibody, wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences. In yet another embodiment, there is provided a hybridoma or engineered cell encoding an antibody or antibody fragment. An additional embodiment comprises a vaccine formulation comprising one or more antibodies or antibody fragments characterized by clone-paired heavy and light chain CDR sequences. In still a further embodiment, there is provided a method of protecting the health of a placenta and/or fetus of a pregnant a subject infected with or at risk of infection with ebolavirus comprising delivering to said subject the antibody or antibody fragment.
    Type: Application
    Filed: July 11, 2019
    Publication date: December 30, 2021
    Inventors: James E. CROWE, Jr., Pavlo GILCHUK, Alexander BUKREYEV
  • HUMAN ZIKA VIRUS ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20210347864
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof.
    Type: Application
    Filed: May 17, 2021
    Publication date: November 11, 2021
    Applicant: Vanderbilt University
    Inventor: James E. CROWE, Jr.
  • ANTIBODY-MEDIATED NEUTRALIZATION OF MARBURG VIRUS
    Publication number: 20210324051
    Abstract: The present disclosure is directed to antibodies binding to Marburg virus (MARV) glycoprotein (GP) and methods of use therefore.
    Type: Application
    Filed: July 1, 2021
    Publication date: October 21, 2021
    Inventors: James E. CROWE, Jr., Andrew I. FLYAK, Alexander BUKREYEV, Philipp ILINYKH
  • HUMAN MONOCLONAL ANTIBODIES THAT NEUTRALIZE PANDEMIC GII.4 NOROVIRUSES
    Publication number: 20210324050
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing norovirus and methods for use thereof. Thus, in accordance with the present disclosure, there is provided a method of detecting a norovirus infection in a subject comprising (a) contacting a sample from the subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences; and (b) detecting norovirus in the sample by binding of the antibody or antibody fragment to a norovirus antigen in the sample.
    Type: Application
    Filed: August 27, 2019
    Publication date: October 21, 2021
    Inventors: James E. Crowe, Jr., Mary Estes
  • HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2)
    Publication number: 20210300999
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: March 25, 2021
    Publication date: September 30, 2021
    Applicant: Vanderbilt University
    Inventors: James E. CROWE, JR., Seth ZOST, Robert CARNAHAN, Pavlo GILCHUK
  • HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2)
    Publication number: 20210277092
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
    Type: Application
    Filed: February 11, 2021
    Publication date: September 9, 2021
    Applicant: Vanderbilt University
    Inventors: James E. Crowe, JR., Seth Zost, Robert Carnahan, Pavlo Gilchuk
  • HUMAN MONOCLONAL ANTIBODIES TO A NEW UNIVERSAL INFLUENZA A HEMAGGLUTININ HEAD DOMAIN EPITOPE
    Publication number: 20210252150
    Abstract: The present disclosure is directed to antibodies binding previously undefined epitopes on influenza A virus hemagglutinin and methods for use thereof.
    Type: Application
    Filed: August 22, 2019
    Publication date: August 19, 2021
    Inventor: James E. Crowe, Jr.
  • Antibody-mediated neutralization of Marburg virus
    Patent number: 11084869
    Abstract: The present disclosure is directed to antibodies binding to Marburg virus (MARV) glycoprotein (GP) and methods of use therefore.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: August 10, 2021
    Assignees: VANDERBILT UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: James E. Crowe, Jr., Andrew I. Flyak, Alexander Bukreyev, Philipp Ilinykh
  • Antibody-mediated neutralization of ebolaviruses
    Patent number: 11054423
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing ebolavirus and methods for use thereof. The present disclosure is directed to a method of detecting an ebolavirus infection in a subject comprising (a) contacting a sample from said subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Table 2, or an antibody fragment thereof; and (b) detecting ebolavirus glycoprotein in said sample by binding of said antibody or antibody fragment to antigen in said sample. In still further embodiments, the present disclosure concerns immunodetection kits for use with the iminunodetection methods described above.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: July 6, 2021
    Assignees: VANDERBILT UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: James E. Crowe, Jr., Andrew I. Flyak, Alexander Bukreyev, Philipp Ilinykh
  • Human Zika virus antibodies and methods of use therefor
    Patent number: 11021533
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: June 1, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventor: James E. Crowe, Jr.
  • HUMAN WEST NILE VIRUS ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20210115115
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing West Nile virus and methods for use thereof.
    Type: Application
    Filed: March 26, 2019
    Publication date: April 22, 2021
    Applicant: Vanderbilt University
    Inventor: James E. Crowe, Jr.
  • Human monoclonal antibodies to lukab toxin
    Patent number: 10981979
    Abstract: The present disclosure is directed to antibodies binding to prefusion and postfusion forms of both human S. aureus and human metapneumovirus F proteins, including neutralizing antibodies, and methods for use thereof.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: April 20, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: James E. Crowe, Jr., Gopal Sapparapu, Isaac Thomsen, Buddy Creech
  • ANTIBODY-MEDIATED NUTRALIZATION OF CHIKUNGUNYA VIRUS
    Publication number: 20210009662
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
    Type: Application
    Filed: January 4, 2019
    Publication date: January 14, 2021
    Inventor: James E Crowe, JR.
  • HUMAN JAPANESE ENCEPHALITIS VIRUS ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20200390879
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing Japanese Encephalitis virus and methods for use thereof.
    Type: Application
    Filed: February 22, 2019
    Publication date: December 17, 2020
    Applicant: Vanderbilt University
    Inventor: James E. Crowe, Jr.