Abstract: The present invention provides vaccine compositions of attenuated respiratory syncytial virus (RSV). More particularly, the attenuated virus may be a derivative of RSV which has been incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. The invention also provides methods for stimulating the immune system of an individual to induce protection against respiratory syncytial virus by administration of attenuated RSV. The invention also provides pure cultures of attenuated RS virus, wherein the virus has been more completely attenuated by the further derivatization of previously identified incompletely attenuated ts or cp mutants.

Abstract: The present invention provides vaccine compositions of attenuated respiratory syncytial virus (RSV). More particularly, the attenuated virus may be a derivative of RSV which has been incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. The invention also provides methods for stimulating the immune system of an individual to induce protection against respiratory syncytial virus by administration of attenuated RSV. The invention also provides pure cultures of attenuated RS virus, wherein the virus has been more completely attenuated by the further derivatization of previously identified incompletely attenuated ts or cp mutants.

Abstract: Human monoclonal antibodies and fragments thereof which bind and neutralize respiratory syncytial virus (RSV) antigenic subgroups A and B are disclosed. Also disclosed are diagnostic and immunotherapeutic methods of using the monoclonal antibodies as well as cell lines producing the monoclonal antibodies.

Abstract: A teaching and learning game for players to learn the sequence of letters in the alphabet. In a preferred embodiment, a set of fifty cards comprising two groups of twenty-five cards each are provided. The first side of one group has marked thereon a respective letter of the alphabet and first indicia to indicate the succeeding letter of the alphabet such that the players are directed to identify the letter of the alphabet which succeeds the letter marked on the first side of the card. The first side of the second group has marked thereon a respective letter of the alphabet and second indicia to indicate the preceding letter of the alphabet such that players are directed to identify the letter of the alphabet which precedes the letter marked on the second side of the card. The second side of the card has third indicia marked thereon to direct the players and to further teach the players the relation between the third indicia and the letters of the alphabet. A set of instructions is also provided.

Abstract: A teaching and learning game for players to learn the sequence of letters in the alphabet. In a preferred embodiment, a set of blocks has a different letter of the alphabet marked on each side of a respective block and further has marked on two sides of the block, first indicia means to indicate the preceding letter, and has marked on two other sides of the block second indicia means to indicate the succeeding letters. Another preferred embodiment includes a set of twenty-six cards having the letters of the alphabet marked in alphabetical sequence on the sides of the cards. Further, one side of each card is marked with first indicia means to indicate the preceding letter and the other side of each card is marked with second indicia means to indicate the succeeding letter. Point scores are awarded to players correctly identifying the preceding or succeeding letter of the alphabet. Selected cards are further marked with scoring indicators to award bonus points to the players.