Abstract: The invention relates generally to methods of treating cancer and other diseases by modulating body temperature. Heat may directed to the hypothalamus of a warm-blooded animal to cool the animal, utilizing the physiological mechanisms that regulate body temperature to effect a compensatory cooling response, thereby lowering body temperature (hypothermia), and rendering other methods of lowering body temperature more effective. Heat may be withdrawn from the hypothalamus of an animal, cooling the hypothalamus, inducing a compensatory increase in body temperature (hyperthermia), and rendering other methods of raising body temperature more effective. Body temperature may be directly modulated by heat-exchange catheter positioned within a blood vessel of a patient.

Abstract: A cam phaser wherein the stator is integral with either the back plate or the front cover plate. The integral stator may be formed by any desired forming technique, such as, for example, by machining, casting, welding, or injection molding. Preferably, however, the integral stator is formed in a single molding step by powdered metal forming using powdered aluminum. Cap seals are provided for sealing the hydraulic chambers of the cam phaser.

Abstract: The invention relates generally to methods of treating cancer and other diseases by modulating body temperature. Heat may directed to the hypothalamus of a warm-blooded animal to cool the animal, utilizing the physiological mechanisms that regulate body temperature to effect a compensatory cooling response, thereby lowering body temperature (hypothermia), and rendering other methods of lowering body temperature more effective. Heat may be withdrawn from the hypothalamus of an animal, cooling the hypothalamus, inducing a compensatory increase in body temperature (hyperthermia), and rendering other methods of raising body temperature more effective. Body temperature may be directly modulated by heat-exchange catheter positioned within a blood vessel of a patient.

Abstract: A modular vane cam phaser assembly for controllably and continuously varying the rotational phase between a camshaft and the crankshaft of a reciprocating internal combustion engine. The module includes a housing mountable to the front of an engine head, the housing supporting on an outer surface thereof a programmably-controllable spool valve for directing pressurized oil to an oil commutator extending into both the housing and a vane phaser wherein a rotor is bolted to the camshaft and a stator is bolted to a timing sprocket. The oil is distributed by the spool valve to opposite sides of the rotor vanes in response to signals generated by an induction cam rotation sensor and by other engine components and processed by a powertrain control module to advance or retard the opening of intake and/or exhaust valves in the engine. The housing is provided with internal passages for supplying oil from an engine port to the spool valve. Preferably, the oil is filtered by a thimble screen as it enters the housing.

Abstract: A vane-type camshaft phaser wherein a coil spring under torsional compression or extension is disposed coaxially within an annular cavity formed in either the cover plate or back plate. A first end of the spring is connected to the cover plate or back plate, and a second end extends from the cavity and is connected to the phaser rotor. The spring constant is selected such that a biasing torque is exerted on the rotor in the valve-opening-advancing direction which counters the inherent valve-opening-retarding torque bias of the camshaft during operation. The bias spring permits more rapid response to a demand on the cam phaser for advancing valve timing, and is also useful in orienting the camshaft advantageously, especially an exhaust valve camshaft, in a timing-advanced position when the engine is shut off or operating at low engine speed.

Abstract: An axially-compact camshaft phaser wherein the phaser bearing flange on the camshaft, connected to a timing chain sprocket or cam drive gear, is axially inverted in comparison to prior art cam phasers so that the bearing flange extends axially and inwardly of the phaser stator and rotor such that radial drive load on the phaser is sustained within the hydraulic portion of the phaser rather than externally thereof. The overall axial length of the phaser may be reduced thereby by about 25% relative to some prior art phasers and the Phaser Envelop volume may be reduced by 15% while maintaining an equivalent torque capacity.

Abstract: Valve lift mechanism for an engine includes a two step variable valve lifter having roller followers for engaging multiple cams on an associated camshaft of the engine and an anti-rotation guide mounted in the engine externally of a cylindrical bore receiving the lifter. The guide engages an axial guide recess in the lifter body without requiring a corresponding recess in the bore. The lifter also has a saddle in a central low lift cam follower engagable by lock pins in an annular body of an associated high lift cam follower to lock the followers together for high valve lift operation. The saddle is disposed axially between a follower roller and a high pressure chamber of a hydraulic lash adjuster of the low lift cam follower so that lock pin loads are transmitted as compressive forces through the low lift follower.

Abstract: A method and compositions for reducing neuronal damage related to an ischemic condition in a mammalian subject are described. The method includes administration of a voltage-gated calcium channel-blocking compound to the subject, 4-24 hours after the onset of the ischemic condition. Such a calcium channel blocking compound is effective to block norepinephrine release in mammalian CNS neuronal cells and is characterized by specific, high affinity binding to omega-conotoxin MVIIA binding sites. Also disclosed are novel peptide structures useful in the treatment method of the invention.

Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.

Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.

Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.

Abstract: A method of reducing neuronal damage related to an ischemic condition in a human patient, such as stroke-induced damage, by administration of a binding/inhibitory omega-conotoxin peptide.

Abstract: Material to be presented to a beam of electro-magnetic radiation to determine a characteristic of the material, for example, the ash content of the material is conveyed as a bed along a flat conveying deck. The initial boundaries of the bed of material are determined by an inverted trough shaped guide of uniform cross-sectional area. The material is then compacted by an extension of the inverted trough shaped guide, the extension being of tapering cross-sectional area.