Abstract: A structural assembly includes a fastener and an additively manufactured component. The additively manufactured component includes a base, a void defined in the base, and a support disposed across the void. The fastener is secured to the base within the void, and the support is captured within a distal end portion of the fastener.

Abstract: Detecting fraudulent activity can be a complex, manual process. In this paper, we adapt statistical properties of count data in a novel algorithm to uncover records exhibiting high risk for fraud. Our method identifies shelves, partitioning data under the counts using a Student's t-distribution. We apply this methodology on a univariate dataset including cumulative results from phone calls to a customer service center. Additionally, we extend this technique to multivariate data, illustrating that the same method is applicable to both univariate and multivariate data.

Abstract: A vehicle body structure includes a vehicle pillar and a unitized reinforcement bracket. The unitized reinforcement bracket is mounted to the vehicle pillar and includes a reinforcement body and one or more stanchions. The reinforcement body extends along a longitudinal direction of the vehicle pillar. The stanchions are located at an inboard side of the vehicle pillar and are configured for mounting a vehicle component.

Abstract: Fuel mixed in water is combusted in a reactor having an internal operating pressure and temperature greater than 3200 psi and greater than 374° C., where the combustion of the fuel is exothermic. Air and fuel are pressurized for introduction into the reactor to a pressure greater than the internal operating pressure using energy generated from the combustion of the fuel, and the pressurized air and the pressurized fuel are injected into the reactor. Pressurized water from the reactor is injected into a drive water column that is partially filled with water to increase a pressure of the drive water column, and water at a temperature less than 100° C. is injected into the reactor to replace water from the reactor that is injected into the drive water column. Pressurized water from the drive water column is used to drive a hydroelectric drive system to produce electrical power.

Abstract: A vehicle body structure includes a vehicle pillar and a unitized reinforcement member. The vehicle pillar includes an inner panel and an outer panel secured to the inner panel to form an internal cavity. The unitized reinforcement member is disposed within the internal cavity of the vehicle pillar and extends along a longitudinal direction of the vehicle pillar. The unitized reinforcement member includes an inner panel portion spaced apart from the inner panel, an outer panel portion coupled to an inner surface of the outer panel, and a connecting portion connecting the inner panel portion and the outer panel portion.

Abstract: A cargo management system for a cargo area of a vehicle includes a first retention feature and a second retention feature. The first retention feature is formed in a first panel structure of the cargo area and adapted to support a first end of a support member. The second retention feature is formed in an opposing second panel structure of the cargo area and adapted to support an opposed second end of the support member. The first and second retention features are configured to inhibit movement of the support member in a longitudinal direction of the vehicle while also allowing the support member to move laterally past one of the first and second retention features into a space defined by a respective panel structure.

Abstract: The present disclosure relates to a method including forming a plurality of components via an additive manufacturing process to define an integral reinforcement member and reinforcing a corner member of a vehicle pillar with the integral reinforcement member. The plurality of components include a first component and a second component. The first and second components formed integrally as a single unit. The first component and the second component include a functionally graded material that is deposited on the corner member via the additive manufacturing process.

Abstract: Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

Abstract: A method of additively manufacturing a part includes placing a standardized blank in a recess within a baseplate, forming the part by successively applying material to the standardized blank, and removing the standardized blank with the applied material from the recess. The successively applied material is at least one of mechanically secured to the standardized blank and chemically secured to the standardized blank such that standardized blank is a feature of the part. The material can be successively applied to the insert by melting and solidifying a metal material onto the standardized blank using at least one of extrusion, selective laser melting, binder jetting, material jetting, directed energy deposition, and sheet lamination, and the standardized blank manages heat during successively applying material to the standardized blank.

Abstract: The present invention relates to an energy management system for a building, comprising at least one heat pump, at least one first thermal energy storage device for providing domestic hot water, at least one second thermal energy storage device for providing space heating, at least one renewable energy generation device, at least one first state of charge analyser for determining the state of charge of the at least one first thermal energy storage device, at least one second state of charge analyser for determining the state of charge of the at least one second thermal energy storage device, and a controller configured to control the at least one heat pump, the at least one first thermal energy storage device, the at least one second thermal energy storage device, and the at least one renewable energy generation device.

Abstract: A system and method for heating and/or cooling at least one space uses a second heat transfer fluid which comprises or consists of water, at least one first encapsulated phase change material and at least one second encapsulated phase change material, wherein the first phase change material has a phase change temperature which is lower than the phase change temperature of the second phase change material. At least two indoor heat exchangers are employed, wherein each of the at least two indoor heat exchangers has a temperature sensor configured to determine a temperature information of the indoor space in which the indoor heat exchanger is located. A controller is employed which receives a temperature information from the temperature sensors and controls the system based on said temperature information. The system and method show an improved efficiency in heating and/or cooling at least one space compared to known systems and methods.

Abstract: The present disclosure relates to reinforcing a vehicle pillar. The vehicle pillar includes a corner member and a reinforcement member. The reinforcement member is additively manufactured and may utilize functionally graded materials. The reinforcement member may be directly deposited on the corner member or may be manufactured separately and coupled thereafter to the corner member. The reinforcement member includes a first component, and a second component. Additionally, the reinforcement member may include a third component that extend angularly from the first and second component to form a Y-shaped structure. The reinforcement member can include multiple attachment joints that facilitate consolidating and coupling the reinforcement member with various vehicle components.

Abstract: In a general aspect, a system can include a reactor for combusting fuel and producing high-temperature, high-pressure liquid as a byproduct, and at least one vessel defining a cavity to be partially filled with water, with an air pocket within the cavity above the water. The system can further include respective valves to control admission of liquid from the reactor into the air pocket when the air pocket has a pressure lower than an operating pressure of the reactor, and to control emission of the water from the at least one vessel through of the vessel after the water in the at least one vessel has been pressurized by the liquid from the reactor. The system can also include a hydroelectric drive system for receiving water emitted from the cavity, and for converting energy in the received water into electrical energy.

Abstract: A cargo management system for a cargo area of a vehicle includes a first retention feature and a second retention feature. The first retention feature is formed in a first panel structure of the cargo area and adapted to support a first end of a support member. The second retention feature is formed in an opposing second panel structure of the cargo area and adapted to support an opposed second end of the support member. The first and second retention features are configured to inhibit movement of the support member in a longitudinal direction of the vehicle while also allowing the support member to move laterally past one of the first and second retention features into a space defined by a respective panel structure.

Abstract: A method includes forming, by a laser beam supplied by a laser cutting system, a laser-cut line in each of a plurality of glass samples. Each different laser-cut line in each different glass sample of the plurality of glass samples is formed when the laser cutting system is at a different process setting. The method also includes subjecting each of the plurality of glass samples with the laser-cut lines to a break test, and obtaining a plurality of break strength values. Each different break strength value of the plurality of break strength values is indicative of a laser-cut line quality of the respective glass sample of the plurality of glass samples.

Abstract: Combination therapies comprising antibody molecules that specifically bind to PD-1 are disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.

Abstract: Provided are compositions and methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.

Abstract: The invention provides a heat transfer system and a method for operating a heat transfer system in which a heat transfer fluid comprising or consisting of a phase change material (PCM) circulates in a cooling circuit. A combined state of phase value of the heat transfer fluid is determined based on information obtained from a sensor system including a temperature sensor and an electrical resistance sensor realized as two separate sensors or as one combined temperature-and-electrical-resistance sensor. The system and method can securely and effectively prevent a possible blocking of the channels of an indoor heat exchanger of the system by solidified PCM and an unwanted deposition of solid PCM (crystals) on heat transfer surfaces of the indoor heat exchanger.

Abstract: Provided are compositions for use in methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.

Abstract: Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.