Abstract: In a general aspect, a system can include a reactor for combusting fuel and producing high-temperature, high-pressure liquid as a byproduct, and at least one vessel defining a cavity to be partially filled with water, with an air pocket within the cavity above the water. The system can further include respective valves to control admission of liquid from the reactor into the air pocket when the air pocket has a pressure lower than an operating pressure of the reactor, and to control emission of the water from the at least one vessel through of the vessel after the water in the at least one vessel has been pressurized by the liquid from the reactor. The system can also include a hydroelectric drive system for receiving water emitted from the cavity, and for converting energy in the received water into electrical energy.

Abstract: Methods, network traffic management apparatuses, non-transitory computer readable media, and network traffic management systems that control network traffic with a subscriber-aware disaggregator include mapping a network address in a network packet received from a client to one of a plurality of subscribers in a subscriber database. A master network address for the one of the subscribers is identified from the mapped network address, where the subscriber has at least one other network address associated with the one of the subscribers. The network packet is routed to a determined one of a plurality of processing nodes and processing threads based on the master network address for the one of the subscribers.

Abstract: Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent, and/or diagnose cancerous or infectious conditions and disorders.

Abstract: A vehicle body structure includes a vehicle pillar and a unitized reinforcement member. The vehicle pillar includes an inner panel and an outer panel secured to the inner panel to form an internal cavity. The unitized reinforcement member is disposed within the internal cavity of the vehicle pillar and extends along a longitudinal direction of the vehicle pillar. The unitized reinforcement member includes an inner panel portion spaced apart from the inner panel, an outer panel portion coupled to an inner surface of the outer panel, and a connecting portion connecting the inner panel portion and the outer panel portion.

Abstract: In a heat transfer system and a method for operating a heat transfer system, a heat transfer fluid having a phase change material (PCM) circulates in a cooling circuit. A combined state of phase value of the heat transfer fluid is determined based on information obtained from a sensor system including a temperature sensor and an electrical resistance sensor realized as two separate sensors or as one combined temperature-and-electrical-resistance sensor. The system and method can securely and effectively prevent a possible blocking of the channels of an indoor heat exchanger of the system by solidified PCM and an unwanted deposition of solid PCM (crystals) on heat transfer surfaces of the indoor heat exchanger.

Abstract: A structural assembly includes a fastener and an additively manufactured component. The additively manufactured component includes a base, a void defined in the base, and a support disposed across the void. The fastener is secured to the base within the void, and the support is captured within a distal end portion of the fastener.

Abstract: Provided are compositions and methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.

Abstract: A charging system for charging a reactor with air used energy produced by the reactor and includes a vessel having a hollow interior cavity partially filled with a liquid slug, a first air pocket within the cavity on a first side of the liquid slug, and a second air pocket within the cavity on a second side of the liquid slug. The liquid slug forms a water trap seal in the cavity between the two pockets and moves within the vessel in a cycle in which gas is loaded into the first air pocket in a first stroke and gas in the first air pocket is compressed in a second stroke. Movement of the liquid slug during the second stroke is caused by an increasing pressure in the second air pocket due to introduction of high-pressure gas from the reactor into the second air pocket.

Abstract: Immunoassay reagents are disclosed that contain a dehydroepiandrosterone sulphate-fluorescein (DHEAS-FITC) conjugate or a dehydroepiandrosterone sulphate-carboxy methoxylamino-dimethyl acridinium ester (DHEAS-CMO-DMAE) conjugate. Also disclosed are immunoassay kits and devices that contain one or more of the DHEAS conjugates. Methods of making and using the DHEAS conjugates are further disclosed.

Abstract: Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

Abstract: A system and method for providing domestic hot water and/or space heating within a building. The system comprises at least one storage vessel comprising a removable cover, wherein an internal volume of the storage vessel is fluidly connected to a source of sewage and/or wastewater from one or more buildings, a water-source heat pump, at least one solar thermal collector, at least one heat transfer circuit. The at least one heat transfer circuit includes at least one fluid line containing a heat transfer fluid, and a controller for controlling an operation of the system. The system has an operation mode in which the controller of the system is configured to connect the at least one solar thermal collector to the at least one storage vessel via the at least one fluid line. The system stores a heat output from the at least one solar thermal collector in sewage and/or wastewater.

Abstract: An energy management system for a building. The Energy management system includes at a first thermal energy storage device for providing domestic hot water, a second thermal energy storage device for providing space heating, an electrical energy storage device, at least three state of charge analysers for determining the state of charge of said devices, a heat pump, a renewable energy generation device for providing electrical energy, and a controller configured to control an operation of said devices and to control an operation of the heat pump. The controller determines a state of charge of the at least one electrical energy storage device based on information of the at least one third state of charge analyser and to control a charging/discharging of the at least one electrical energy storage device based on a determined a state of charge.

Abstract: A charging system for charging a reactor with air used energy produced by the reactor and includes a vessel having a hollow interior cavity partially filled with a liquid slug, a first air pocket within the cavity on a first side of the liquid slug, and a second air pocket within the cavity on a second side of the liquid slug. The liquid slug forms a water trap seal in the cavity between the two pockets and moves within the vessel in a cycle in which gas is loaded into the first air pocket in a first stroke and gas in the first air pocket is compressed in a second stroke. Movement of the liquid slug during the second stroke is caused by an increasing pressure in the second air pocket due to introduction of high-pressure gas from the reactor into the second air pocket.

Abstract: Fuel mixed in water is combusted in a reactor having an internal operating pressure and temperature greater than 3200 psi and greater than 374° C., where the combustion of the fuel is exothermic. Air and fuel are pressurized for introduction into the reactor to a pressure greater than the internal operating pressure using energy generated from the combustion of the fuel, and the pressurized air and the pressurized fuel are injected into the reactor. Pressurized water from the reactor is injected into a drive water column that is partially filled with water to increase a pressure of the drive water column, and water at a temperature less than 100° C. is injected into the reactor to replace water from the reactor that is injected into the drive water column. Pressurized water from the drive water column is used to drive a hydroelectric drive system to produce electrical power.

Abstract: A method includes forming, by a laser beam supplied by a laser cutting system, a laser-cut line in each of a plurality of glass samples. Each different laser-cut line in each different glass sample of the plurality of glass samples is formed when the laser cutting system is at a different process setting. The method also includes subjecting each of the plurality of glass samples with the laser-cut lines to a break test, and obtaining a plurality of break strength values. Each different break strength value of the plurality of break strength values is indicative of a laser-cut line quality of the respective glass sample of the plurality of glass samples.

Abstract: A structural assembly includes a fastener and an additively manufactured component. The additively manufactured component includes a base, a void defined in the base, and a support disposed across the void. The fastener is secured to the base within the void, and the support is captured within a distal end portion of the fastener.

Abstract: A vehicle body structure includes a vehicle pillar and a unitized reinforcement bracket. The unitized reinforcement bracket is mounted to the vehicle pillar and includes a reinforcement body and one or more stanchions. The reinforcement body extends along a longitudinal direction of the vehicle pillar. The stanchions are located at an inboard side of the vehicle pillar and are configured for mounting a vehicle component.

Abstract: Fuel mixed in water is combusted in a reactor having an internal operating pressure and temperature greater than 3200 psi and greater than 374° C., where the combustion of the fuel is exothermic. Air and fuel are pressurized for introduction into the reactor to a pressure greater than the internal operating pressure using energy generated from the combustion of the fuel, and the pressurized air and the pressurized fuel are injected into the reactor. Pressurized water from the reactor is injected into a drive water column that is partially filled with water to increase a pressure of the drive water column, and water at a temperature less than 100° C. is injected into the reactor to replace water from the reactor that is injected into the drive water column. Pressurized water from the drive water column is used to drive a hydroelectric drive system to produce electrical power.

Abstract: A vehicle body structure includes a vehicle pillar and a unitized reinforcement member. The vehicle pillar includes an inner panel and an outer panel secured to the inner panel to form an internal cavity. The unitized reinforcement member is disposed within the internal cavity of the vehicle pillar and extends along a longitudinal direction of the vehicle pillar. The unitized reinforcement member includes an inner panel portion spaced apart from the inner panel, an outer panel portion coupled to an inner surface of the outer panel, and a connecting portion connecting the inner panel portion and the outer panel portion.

Abstract: A cargo management system for a cargo area of a vehicle includes a first retention feature and a second retention feature. The first retention feature is formed in a first panel structure of the cargo area and adapted to support a first end of a support member. The second retention feature is formed in an opposing second panel structure of the cargo area and adapted to support an opposed second end of the support member. The first and second retention features are configured to inhibit movement of the support member in a longitudinal direction of the vehicle while also allowing the support member to move laterally past one of the first and second retention features into a space defined by a respective panel structure.