Abstract: The present disclosure pertains to an apparatus and methods of an imaging device for obtaining images from the walls of luminal organs or a surgical cavity. The device is capable of passage through luminal organs or introduction into surgical cavities, and obtains images by rapidly scanning a focused light beam on the tissue to be imaged and receiving light from the tissue. The device comprises at least one mechanism for projecting a 2-dimensional (2-D) optical pattern, such as a 2-D scanner (508) or a 2-D optical array forming a closed loop scan pattern (506). The device comprises at least one other beam scanning mechanism, such as a rotary or angular scanner (510) such that cycloid scan pattern is formed on the surface to be scanned, and also has embodiments of focusing optics at different regimes of numerical aperture. The disclosure also describes methods for accurate image reconstruction with embodiments of hardware control and post-acquisition processing.

Abstract: A computer-implemented method of imaging an object, and an optical coherent tomography (OCT) imaging system implementing same.

Abstract: The present disclosure pertains to an apparatus and methods of an imaging device for obtaining images from the walls of luminal organs or a surgical cavity. The device is capable of passage through luminal organs or introduction into surgical cavities, and obtains images by rapidly scanning a focused light beam on the tissue to be imaged and receiving light from the tissue. The device comprises at least one mechanism for projecting a 2-dimensional (2-D) optical pattern, such as a 2-D scanner (508) or a 2-D optical array forming a closed loop scan pattern (506). The device comprises at least one other beam scanning mechanism, such as a rotary or angular scanner (510) such that cycloid scan pattern is formed on the surface to be scanned, and also has embodiments of focusing optics at different regimes of numerical aperture. The disclosure also describes methods for accurate image reconstruction with embodiments of hardware control and post-acquisition processing.

Abstract: An imaging (e.g., with an optical coherence tomography system) method that includes 1) acquiring repeated B-scans in a manner consistent with forming images, 2) processing the acquired images according to a variable interscan time analysis (VISTA) method, and 3) generating and displaying a color-mapped image pixel color of the color-mapped image fluid flow speed, or a related quantity.

Abstract: An apparatus and method for real-time optical imaging of a tissue specimen.

Abstract: A computer-implemented method of imaging an object, and an optical coherent tomography (OCT) imaging system implementing same.

Abstract: An apparatus and method for real-time optical imaging of a tissue specimen.

Abstract: An apparatus and method for real-time optical imaging of a tissue specimen.

Abstract: An imaging (e.g., with an optical coherence tomography system) method that includes 1) acquiring repeated B-scans in a manner consistent with forming images, 2) processing the acquired images according to a variable interscan time analysis (VISTA) method, and 3) generating and displaying a color-mapped image pixel color of the color-mapped image fluid flow speed, or a related quantity.

Abstract: An apparatus and method for real-time optical imaging of a tissue specimen.

Abstract: Images of an object, such as OCT scans of a human eye, can include distortions and data gaps due to relative motion of the object and the image acquisition device. Methods and systems for correction of such distortions and data gaps are described herein. Motion-corrected data is arrived at by applying three-dimensional transforms to input three-dimensional data sets that represent at least partially overlapping regions of the imaged object. The three dimensional transforms are computed based on an objective function that accounts for similarity between the transformed three-dimensional data sets and the estimated motion of the object relative to an imaging instrument. Methods and systems described herein advantageously eliminate the need for postulated assumptions and reliance on landmarks and are capable of filling data gaps, thereby producing high quality, undistorted images of objects subject to movement during imaging.

Abstract: The invention pertains to an apparatus and methods of a medical imaging device for obtaining images from the walls of luminal organs or a surgical cavity. The invention is a rigid enclosure that is capable of passage through luminal organs or introduction into surgical cavities, and obtains images by rapidly scanning a focused light beam on the tissue to be imaged and receiving light from the tissue. The invention has at least one beam scanning mechanism and has multiple embodiments of scanning and focusing optics at different regimes of numerical aperture. The invention also describes methods for correcting inaccurate beam scanning. The device is capable of performing imaging, image guided therapy, tissue excision, or other interventional procedures.

Abstract: Images of an object, such as OCT scans of a human eye, can include distortions and data gaps due to relative motion of the object and the image acquisition device. Methods and systems for correction of such distortions and data gaps are described herein. Motion-corrected data is arrived at by applying three-dimensional transforms to input three-dimensional data sets that represent at least partially overlapping regions of the imaged object. The three dimensional transforms are computed based on an objective function that accounts for similarity between the transformed three-dimensional data sets and the estimated motion of the object relative to an imaging instrument. Methods and systems described herein advantageously eliminate the need for postulated assumptions and reliance on landmarks and are capable of filling data gaps, thereby producing high quality, undistorted images of objects subject to movement during imaging.

Abstract: Images of an object, such as OCT scans of a human eye, can include distortions and data gaps due to relative motion of the object and the image acquisition device. Methods and systems for correction of such distortions and data gaps are described herein. Motion-corrected data is arrived at by applying three-dimensional transforms to input three-dimensional data sets that represent at least partially overlapping regions of the imaged object. The three dimensional transforms are computed based on an objective function that accounts for similarity between the transformed three-dimensional data sets and the estimated motion of the object relative to an imaging instrument. Methods and systems described herein advantageously eliminate the need for postulated assumptions and reliance on landmarks and are capable of filling data gaps, thereby producing high quality, undistorted images of objects subject to movement during imaging.

Abstract: A control system for improving and stabilizing Fourier domain mode locking (FDML) operation. The control system may also provide regulation of FDML operational parameters such as filter tuning, laser gain, polarization, polarization chromaticity, elliptical polarization retardance, and/or dispersion. The control system may be located internal to or external from the FDML laser cavity.

Abstract: A control system for improving and stabilizing Fourier domain mode locking (FDML) operation. The control system may also provide regulation of FDML operational parameters such as filter tuning, laser gain, polarization, polarization chromaticity, elliptical polarization retardance, and/or dispersion. The control system may be located internal to or external from the FDML laser cavity.

Abstract: Images of an object, such as OCT scans of a human eye, can include distortions and data gaps due to relative motion of the object and the image acquisition device. Methods and systems for correction of such distortions and data gaps are described herein. Motion-corrected data is arrived at by applying three-dimensional transforms to input three-dimensional data sets that represent at least partially overlapping regions of the imaged object. The three dimensional transforms are computed based on an objective function that accounts for similarity between the transformed three-dimensional data sets and the estimated motion of the object relative to an imaging instrument. Methods and systems described herein advantageously eliminate the need for postulated assumptions and reliance on landmarks and are capable of filling data gaps, thereby producing high quality, undistorted images of objects subject to movement during imaging.

Abstract: A control system for improving and stabilizing Fourier domain mode locking (FDML) operation. The control system may also provide regulation of FDML operational parameters such as filter tuning, laser gain, polarization, polarization chromaticity, elliptical polarization retardance, and/or dispersion. The control system may be located internal to or external from the FDML laser cavity.

Abstract: A mirror system for use in generating a short duration laser pulse is disclosed. The system includes first and second double-chirped mirrors disposed along an optical path within a cavity, where the second double-chirped mirror includes an additional phase-shifting layer as compared to the first double-chirped mirror. The additional phase-shifting layer causes the mirror system during use to produce a laser pulse that is characterized by oscillations in group delay substantially reduced in amplitude in comparison to oscillations in group delay for a pulse produced by the same system without the additional phase-shifting layer.

Abstract: A fiber optic needle probe for measuring or imaging the internal structure of a specimen includes a needle defining a bore, an optical fiber substantially positioned within the bore, and a beam director in optical communication with the optical fiber. At least a portion of the wall of the needle is capable of transmitting light. The beam director directs light from the optical fiber to an internal structure being imaged and receives light from the structure through a transparent portion of the wall. An actuating device causes motion of any, or all of, the needle, optical fiber, and beam director to scan the internal structure of the specimen. The fiber optic needle probe allows imaging inside a solid tissue or organ without intraluminal insertion. When used in conjunction with an OCT imaging system, the fiber optic needle probe enables tomographic imaging of the microstructure of internal organs and tissues which were previously impossible to image in a living subject.