Abstract: Methods and devices for the tailored restraint of two separate bones, in which the bones are generally permitted to rotate relative to one another, or move toward each other, but are restrained from separating beyond a predetermined, fixed distance. In some embodiments, the restraint is provided by compressing a tether into a notched groove.

Abstract: This invention relates to polynucleotides comprising optimized CLN5 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a CLN5 gene or aberrant activity of a CLN5 gene product in the subject, such as CLN5 disease.

Abstract: This invention relates to polynucleotides comprising optimized CLN5 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a CLN5 gene or aberrant activity of a CLN5 gene product in the subject, such as CLN5 disease.

Abstract: This invention relates to polynucleotides comprising optimized FIG. 4 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a FIG. 4 gene or aberrant activity of a FIG. 4 gene product in the subject, such as CMT4J.

Abstract: A system includes a plug assembly having a housing configured to be positioned within a first passageway formed in a wellhead component. A channel is formed in the housing, and the channel is configured to enable fluid to flow from a bore of the wellhead component into the channel. A sensor is supported by the housing and is configured to measure a condition of the fluid within the channel. An annular seal is configured to extend between an outer surface of the housing and an inner surface of a second passageway formed in a flange that circumferentially surrounds at least part of the plug assembly while the flange is coupled to the wellhead component.

Abstract: Systems, methods, and apparatuses for depositing polymer and/or other layers onto surfaces of, for example, implantable medical devices. In some embodiments, the polymer and/or other coating layers are deposited via plasma polymerization deposition. In some embodiments, primer layers are deposited via plasma polymerization deposition. A coating layer can be formed over a primer layer. The deposited layers can be bioresorbable and/or bioabsorbable.

Abstract: A hollow cylinder (102) contains hot water for making a hot beverage, for example, coffee. The cylinder (102) has an inner wall (102a) extending along an axis (104) from an open upper end (102b) to an open lower end (102c) of the cylinder. A perforated closure (106) is releasably securable to the cylinder (102) to hold the coffee at the lower end (102c). A cap (110) carries a plunger (112) configured and arranged for sealing engagement with the inner wall (102a) of the cylinder (102). In use, the cap (110) is rotatable on the cylinder (102) about the axis (104) and is connected to the cylinder (102) by a helical formation. Rotation of the cap (110) on the cylinder (102) drives the plunger (112) towards the lower end (102c) of the cylinder (102) to press the hot water through the perforated closure (106) and the coffee held thereon and then into the vessel (118).

Abstract: Described herein is a coupling device, associated parts and a method of use thereof. In one aspect, a coupling device is described comprising a sleeve with an inner surface that encloses at least part of at least one elongated element to be coupled; and at least one deformation means fitted with interference between, and causing local deformation about, at least part of the inner surface of the sleeve and/or an adjacent outer surface of the at least one elongated element. A deformation means insertion tool, a coupling sleeve, a deformation means, and a method of coupling at least one element are also described. The described coupling device, associated parts and a method of use offer the ability to couple together different elements in a strong and/or ductile manner, coupling being tuneable as needed to suit the preferred application. The coupling described may overcome art issues associated with bulky size of coupling, in particular, radial protrusion.

Abstract: Ether amines, or salts thereof, are proposed for use herein as lubricity additives for drilling fluids. Methods for wellbore operations and for improving lubricity include adding an ether amine to the drilling fluid. The ether amine is represented by the general formula: where R1 is represented by the general formula: where R5 is a straight chain, branched, or cyclic aliphatic radical with about 3 to 20 carbon atoms; X is 0 to 10; R2 is a straight chain, branched, or cyclic aliphatic radical with about 3 to 20 carbon atoms; and R3 and R4 are each one of H or a straight chain, branched, or cyclic aliphatic radical.

Abstract: A system includes a plug assembly having a housing configured to be positioned within a first passageway formed in a wellhead component. A channel is formed in the housing, and the channel is configured to enable fluid to flow from a bore of the wellhead component into the channel. A sensor is supported by the housing and is configured to measure a condition of the fluid within the channel. An annular seal is configured to extend between an outer surface of the housing and an inner surface of a second passageway formed in a flange that circumferentially surrounds at least part of the plug assembly while the flange is coupled to the wellhead component.

Abstract: Described herein is a coupling device, associated parts and a method of use thereof. In one aspect, a coupling device is described comprising a sleeve with an inner surface that encloses at least part of at least one elongated element to be coupled; and at least one deformation means fitted with interference between, and causing local deformation about, at least part of the inner surface of the sleeve and/or an adjacent outer surface of the at least one elongated element. A deformation means insertion tool, a coupling sleeve, a deformation means, and a method of coupling at least one element are also described. The described coupling device, associated parts and a method of use offer the ability to couple together different elements in a strong and/or ductile manner, coupling being tuneable as needed to suit the preferred application. The coupling described may overcome art issues associated with bulky size of coupling, in particular, radial protrusion.

Abstract: This invention relates to polynucleotides comprising optimized SLC13A5 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a SLC13A5 gene or aberrant activity of a SLC13A5 gene product in the subject, such as citrate transporter disorder.

Abstract: Described herein is a coupling device, associated parts and a method of use thereof. In one aspect, a coupling device is described comprising a sleeve with an inner surface that encloses at least part of at least one elongated element to be coupled; and at least one deformation means fitted with interference between, and causing local deformation about, at least part of the inner surface of the sleeve and/or an adjacent outer surface of the at least one elongated element. A deformation means insertion tool, a coupling sleeve, a deformation means, and a method of coupling at least one element are also described. The described coupling device, associated parts and a method of use offer the ability to couple together different elements in a strong and/or ductile manner, coupling being tuneable as needed to suit the preferred application. The coupling described may overcome art issues associated with bulky size of coupling, in particular, radial protrusion.

Abstract: A system includes a plug assembly having a housing configured to be positioned within a first passageway formed in a wellhead component. A channel is formed in the housing, and the channel is configured to enable fluid to flow from a bore of the wellhead component into the channel. A sensor is supported by the housing and is configured to measure a condition of the fluid within the channel. An annular seal is configured to extend between an outer surface of the housing and an inner surface of a second passageway formed in a flange that circumferentially surrounds at least part of the plug assembly while the flange is coupled to the wellhead component.

Abstract: A parallelogram suspension in a bicycle, the parallelogram suspension comprising a first swing arm rotatably coupled to a seat post at a first end of the first swing arm; a second swing arm rotatably coupled to the seat post at a first end of the second swing arm; a linkage rotatably coupled between a second end of the first swing arm and a second end of the second swing arm; a deformable support disposed in a volume defined between the first swing arm, the second swing arm, and the linkage; and a release configured to selectively open the volume to release the deformable support.

Abstract: This invention relates to polynucleotides comprising optimized aspartylglucosaminidase (AGA) open reading frames and vectors and cells comprising the same. The invention further relates to methods of using the same for delivery of the open reading frame to a cell or a subject and methods for treating aspartylglucosaminuria (AGU) in a subject.

Abstract: Described herein is a coupling device, associated parts and a method of use thereof. In one aspect, a coupling device is described comprising a sleeve with an inner surface that encloses at least part of at least one elongated element to be coupled; and at least one deformation means fitted with interference between, and causing local deformation about, at least part of the inner surface of the sleeve and/or an adjacent outer surface of the at least one elongated element. A deformation means insertion tool, a coupling sleeve, a deformation means, and a method of coupling at least one element are also described. The described coupling device, associated parts and a method of use offer the ability to couple together different elements in a strong and/or ductile manner, coupling being tuneable as needed to suit the preferred application. The coupling described may overcome art issues associated with bulky size of coupling, in particular, radial protrusion.

Abstract: A system includes a plug assembly having a housing configured to be positioned within a first passageway formed in a wellhead component. A channel is formed in the housing, and the channel is configured to enable fluid to flow from a bore of the wellhead component into the channel. A sensor is supported by the housing and is configured to measure a condition of the fluid within the channel. An annular seal is configured to extend between an outer surface of the housing and an inner surface of a second passageway formed in a flange that circumferentially surrounds at least part of the plug assembly while the flange is coupled to the wellhead component.

Abstract: This invention relates to polynucleotides comprising UBE3A open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a UBE3A gene or aberrant activity of a UBE3A gene product in the subject, such as Angelman Syndrome.

Abstract: This invention relates to polynucleotides comprising optimized SUMF1 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for deliver) of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a SUMF1 gene or aberrant activity of a SUMF1 gene product in the subject, such as SUMF1 disease.