Abstract: Methods for diagnosing skin lesions are disclosed. Generally, the method include topically administering an IRM compound to a treatment area for a period of time and in an amount effective to cause a visible change in the appearance of a skin lesion including, in some cases, causing subclinical lesions to become visible. Suitable IRM compounds include agonists of one or more TLRs.

Abstract: Methods of improving skin quality are disclosed. Generally, the methods include topically administering an IRM compound to a treatment area of skin for a period of time and in an amount effective for improving the quality of the skin. Suitable IRM compound compounds include agonists of one or more TLRs.

Abstract: Methods and systems are disclosed for drilling counter sink fastener holes in composite materials with conductive foil lightning strike protection systems. Initially a non-destructive depth detector is scanned over a prospective fastener hole location. Then the depth of a conductive foil below a surface is detected. When the detected depth is less than a predetermined depth, a signal that indicates that a countersink fastener hole may be drilled is output. When the detected depth is greater than a predetermined depth, a signal that indicates that a countersink fastener hole may not be drilled is output.

Abstract: A fuel cell or electrochemical cell has a catalytic electrode and an electrically conductive contact element facing the electrode. The electrically conductive contact element conducts electrical current from the electrode and has a surface that includes a plurality of passivated regions and a plurality of non-passivated regions dispersed among the passivated regions. The surface is further coated with an electrically conductive, corrosion resistant coating. Methods include treating the electrically conductive contact element by passivation to resist corrosion while still maintaining electrical conductivity of the element.

Abstract: A method and apparatus for nondestructive inspection of interwoven wire fabric components. The apparatus comprises a probe, a power source, and a display system. The probe is capable of creating a magnetic field for a plurality of wires in an interwoven wire fabric component such that disturbances of the magnetic field caused by the plurality of wires can be detected. The power is a source connected to the probe and is capable of sending an alternating current through the probe to generate the magnetic field for the wire. The display system is connected to the probe and is capable of displaying results from detecting the magnetic field and disturbances of the magnetic field.

Abstract: Embodiments of techniques to verify the interference fit of fasteners are disclosed. In one embodiment, a method includes aligning a probe proximate a fastener, the fastener being disposed within a material. A dynamic stress signal is generated from the probe using a low frequency transducer, and the dynamic stress signal is interrogated after it passes between the fastener and the material. An interference fit is then determined based on the interrogated dynamic stress signal.

Abstract: Optical metrology methods, apparatuses, and systems for detecting seal integrity. These comprise changing an air pressure inside a chamber to an excitation pressure level when the chamber is placed over a segment of a surface of a structure having one or more seal features and determining whether the integrity of any of the one or more seal features has been compromised by determining, using an optical system, whether any of the one or more seal features have been deformed by the changing of the air pressure.

Abstract: Pharmaceutical packages and methods for enhancing the safety of imiquimod when used to treat children affected by skin disorders are disclosed. More particularly, the safety profile of imiquimod use is enhanced by providing information to the children, guardians of the children, including parents and health care professionals, that systemic absorption of imiquimod and other effects may be observed when imiquimod therapy is used to treat children of between about 2 and about 12 years of age. Examples of systemic absorption include a serum imiquimod concentrations of less than about 2 ng/mL, a decrease in median white blood cell count by about 1.4*109/L or a decrease in median absolute neutrophil count by about 1.42*109/L.

Abstract: A method of treating actinic keratosis including applying topically to an actinic keratosis lesion twice per week for a duration of 8 weeks a formulation comprising 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine.

Abstract: A self-aligning probe assembly has one or more ultrasonic transducers adapted to transmit an ultrasonic shear wave into the inside surface of the hollow structure such as an aircraft fuse pin and to receive the shear wave emerging from the inside surface of the hollow structure. The nature of the received shear wave indicates the presence of flaws or damage in the inspected part. The probe assembly can be used to inspect fuse pins on aircraft without having to remove the aircraft engines.

Abstract: A fuel cell system and process using an organic Rankine cycle to produce shaft work to operate a fuel cell system component such as an air compressor. The air compressor delivers compressed air to a fuel cell stack. The steps of the Rankine cycle include pumping a liquid working fluid to an elevated pressure, heating the fluid to a gas, expanding the high temperature and high-pressure gas through an expander to produce shaft work used to drive a fuel cell system component such as an air compressor, and then removing energy from the cooling fluid to change the gas back to a liquid, and repeating the cycle. The liquid fluid can be heated by an external boiler, or one of the components of the fuel cell system such as the combustor and/or the fuel cell stack.

Abstract: A bipolar plate assembly is provided for use in a fuel cell stack to supply reactants to the anode and cathode sides of fuel cells within the stack. The bipolar plate assembly includes first and second sub-plates, each including a first face surface having a coolant flow field formed therein and a second face surface having a reactant flow field formed therein. The coolant fields of the first and second sub-plates include regions of varying flow volume, having respective flow resistance therebetween. The regions of varying flow volume enable variable cooling across the fuel cell stack, thereby enabling a constant temperature to be achieved across the fuel cell stack.

Abstract: A fuel cell system and process using an organic Rankine cycle to produce shaft work to operate a fuel cell system component such as an air compressor. The air compressor delivers compressed air to a fuel cell stack. The steps of the Rankine cycle include pumping a liquid working fluid to an elevated pressure, heating the fluid to a gas, expanding the high temperature and high-pressure gas through an expander to produce shaft work used to drive a fuel cell system component such as an air compressor, and then removing energy from the cooling fluid to change the gas back to a liquid, and repeating the cycle. The liquid fluid can be heated by an external boiler, or one of the components of the fuel cell system such as the combustor and/or the fuel cell stack.

Abstract: The present invention relates to an electrochemical cell having a catalytic electrode and an electrically conductive contact element facing the electrode. The electrically conductive contact element conducts electrical current from the electrode and has a surface comprising a plurality of passivated regions, and a plurality of non-passivated regions dispersed among the passivated regions. The surface further is coated with an electrically conductive, corrosion resistant coating. Other preferred aspects of the present invention include methods of treating the electrically conductive contact element by passivation to resist corrosion while still maintaining electrical conductivity.

Abstract: A fuel cell system and process using an organic Rankine cycle to produce shaft work to operate a fuel cell system component such as an air compressor. The air compressor delivers compressed air to a fuel cell stack. The steps of the Rankine cycle include pumping a liquid working fluid to an elevated pressure, heating the fluid to a gas, expanding the high temperature and high-pressure gas through an expander to produce shaft work used to drive a fuel cell system component such as an air compressor, and then removing energy from the cooling fluid to change the gas back to a liquid, and repeating the cycle. The liquid fluid can be heated by an external boiler, or one of the components of the fuel cell system such as the combustor and/or the fuel cell stack.

Abstract: A fuel cell cooling system is provided with a coolant pump for pumping fluid through coolant flow field passages in a fuel cell stack. A pressure control mechanism is provided for maintaining a pressure level within the fuel cell stack for causing a phase change of the coolant within the stack. Allowing the coolant to change phase to a gas inside the stack reduces the amount of coolant needed to cool the fuel cell stack and thereby reduces the energy needed to pump the coolant through the fuel cell stack.

Abstract: The present invention relates to an electrochemical cell having a catalytic electrode and an electrically conductive contact element facing the electrode. The electrically conductive contact element conducts electrical current from the electrode and has a surface comprising a plurality of passivated regions, and a plurality of non-passivated regions dispersed among the passivated regions. The surface further is coated with an electrically conductive, corrosion resistant coating. Other preferred aspects of the present invention include methods of treating the electrically conductive contact element by passivation to resist corrosion while still maintaining electrical conductivity.

Abstract: Methods of improving skin quality are disclosed. Generally, the methods include topically administering an IRM compound to a treatment area of skin for a period of time and in an amount effective for improving the quality of the skin. Suitable IRM compound compounds include agonists of one or more TLRs.

Abstract: Methods for diagnosing skin lesions are disclosed. Generally, the method include topically administering an IRM compound to a treatment area for a period of time and in an amount effective to cause a visible change in the appearance of a skin lesion including, in some cases, causing subclinical lesions to become visible. Suitable IRM compounds include agonists of one or more TLRs.

Abstract: The present invention provides a method of protecting a subject against UV-induced epidermal neoplasia. Generally, the method includes administering to a subject an IRM compound in an amount effective to provide protection against UV-induced epidermal neoplasia. The present invention also provides compositions that include an IRM compound in an amount effective for providing protection against UV-induced epidermal neoplasia.