Abstract: A hat (200) for a neonate (120) comprising: a central portion (201), a first side portion (202) and second side portion (203) attached to opposite sides of the central portion (201), a first fastener (208); a top flap (204) and a second fastener (211). The hat (200) has an unfolded configuration and a worn configuration. In the unfolded configuration the first and second portions (202, 203) extend away from each other from the central portion (201) in opposite directions. In the worn configuration the hat (200) wraps a neonate's head with the central portion (201) in contact with the back of the neonate's head, the first portion (202) wrapped around a first side of the neonate's head and the second portion (203) wrapped around a second side of the neonate's head.

Abstract: The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) or (Ia) wherein R1-R4, A and B are as defined herein. Also provided are pharmaceutical compositions and combinations comprising such agents.

Abstract: A computer-implemented method comprising: obtaining text from text-based messages sent between a patient and a therapist providing psychological therapy; determining at least one feature of the text; and determining a characteristic of the patient and/or the therapist using the at least one feature.

Abstract: A unified radio system for providing wireless communication to a communication device on an aircraft regardless of aircraft altitude may include a terrestrial network including a plurality of terrestrial base stations configured to communicate primarily in a ground communication layer below a first altitude, an ATG network including a plurality of ATG base stations configured to communicate primarily in an ATG communication layer above a second altitude, an air-to-air mesh network for data relays through connected aircraft, and an aircraft with an onboard antenna assembly and a unified radio. The unified radio may be configured to monitor network parameters of the terrestrial network and the ATG network and switch between a currently serving network and a non-serving network based on the network parameters.

Abstract: A global positioning system (GPS) receiver may include an antenna configured to receive GPS signals from GPS satellites, a radio frequency (RF) front end configured to pre-process signals received by the antenna, a demodulator/converter configured to perform demodulation and analog-to-digital conversion of output signals received from the RF front end, a clock configured to provide a consistent clock signal, and a digital signal processor configured to receive the clock signal and make time and code measurements associated with determining a location of the GPS receiver based on the signals received by the antenna. The GPS receiver may be configured to eliminate reflected or indirect signals from the time and code measurements.

Abstract: A network controller including processing circuitry may be configured to receive dynamic position information indicative of a three dimensional position of at least one mobile communication node, compare fixed position information indicative of fixed geographic locations of respective access points of a network to the dynamic position information to determine a relative position of the at least one mobile communication node relative to at least one of the access points based on the fixed position information and the dynamic position information, and provide network control instructions to at least one network asset based on the relative position.

Abstract: An antenna assembly includes a plurality of antenna elements disposed in a circular pattern and equidistant from each other in angular separation relative to a common reference point at a center of the circular pattern. The antenna assembly may include or be operably coupled to a phase control module configured to apply selected phase fronts to each of the antenna elements to generate constructive and destructive interference patterns to define a directive beam in a desired direction. The selected phase fronts may include no phase adjustment, a positive phase adjustment value and a negative phase adjustment value, the positive and negative phase adjustment values each having a same magnitude.

Abstract: Data storage is provided using double-stranded nucleic acid molecules provided on a thermal control device comprising a plurality of sites and temperature control circuitry to independently control a temperature of each of the plurality of sites. The temperature control circuitry, controls the site temperatures to provide a different temperature at a target site compared to other sites of the plurality of sites. The different temperatures at the target site and the other sites provide a greater probability of a read or write operation acting on the target site compared to the other sites. The temperature-based addressing helps to increase physical storage density.

Abstract: A heat exchanger bracket for an automotive cooling module may include a first mounting assembly disposed at a first end of the heat exchanger bracket, a second mounting assembly disposed at a second end of the heat exchanger bracket, and a bracket container disposed between the first and second ends of the heat exchanger bracket. The first mounting assembly may include a first free floating retention point, and the second mounting assembly may include a second free floating retention point. The bracket container may be configured to receive a heat exchanger. The bracket container may include a first flexible retainer disposed at a first longitudinal end thereof, and a second flexible retainer disposed at a second longitudinal end thereof. The first and second flexible retainers may be configured to engage opposing longitudinal ends of the heat exchanger responsive to insertion of the heat exchanger into the bracket container.

Abstract: A method of interference mitigation may include receiving a desired signal from an asset of the system at an antenna assembly and associating the desired signal with relative phase distribution information based on a relative location of origin of the desired signal where the relative phase distribution information is predetermined for the antenna assembly. The method further includes receiving an interfering signal and associating the interfering signal with relative phase distribution information based on a relative location of origin of the interfering signal where the desired signal and the interfering signal forming a received signal set. The method further includes normalizing signals of the received signal set to respective relative phases associated with each respective relative location of origin, and performing interference cancellation of the interfering signal based on the normalized signals.

Abstract: A series of hybridisations is performed for forming a target double-stranded nucleic acid from initial fragments, where each further hybridisation step hybridises the direct products of a pair of earlier hybridisation steps. For at least one further hybridisation step HF, both of the corresponding pair of earlier hybridisation steps HE comprise an error-detecting type of hybridisation step, which includes an error detecting operation to detect whether the hybridised fragments formed in the error-detecting type of hybridisation step HE comprise at least one erroneous hybridised fragment, and discarding at least part of the erroneous fragment to exclude it from a subsequent further hybridisation step. By detecting and removing erroneous fragments throughout a staged and controlled hybridisation process, erroneous fragments are prevented from diluting the pool of error-free fragments at each hybridisation step, to improve yield.

Abstract: In one embodiment, the present disclosure relates to an electrosurgical device that includes an outer body, an inner body disposed partially within the outer body, three plates and an insulator. A first plate of the three plates includes a plurality of apertures and is positioned so that each of two projections extending from the inner body extend through a respective aperture of the plurality of apertures of the first plate. A second plate and a third plate of the three plates are both disposed on the first plate such that each of the two projections extends through an aperture of the second plate or the third plate, the second and third plates being fixed to a respective projection. The insulator is disposed around the inner body and is attached to the outer body at a first end and abuts the first plate at a second end opposite the first end.

Abstract: The invention relates to inhibitors of CDK12 (cyclin-dependent kinase 12), and there use in the treatment or prevention of a disorder in a subject caused by the generation of repeat expansion transcripts.

Abstract: A temperature control device (2) comprises a number of active thermal sites (6) disposed at respective locations on a substrate (10), each comprising a heating element (13) for applying a variable amount of heat to a corresponding site of a medium and a thermal insulation layer (16) disposed between the heating element and the substrate. At least one passive thermal region (8) is disposed between the active thermal sites (6) on the substrate (10), each passive thermal region (8) comprising a thermal conduction layer (18) for conducting heat from a corresponding portion of the medium to the substrate (10). The thermal conduction layer (18) has a lower thermal resistance in a direction perpendicular to a plane of the substrate (10) than the thermal insulation layer (16). This enables precise control over both heating and cooling of individual sites in a flowing fluid, for example.

Abstract: An antenna assembly includes a driven element, a first set of antenna elements disposed a first distance from the driven element such that each element of the first set of antenna elements is equidistant from adjacent elements of the first set of antenna elements, and a second set of antenna elements disposed a second distance from the driven element such that each element of the second set of antenna elements is equidistant from adjacent elements of the second set of antenna elements, the second distance being larger than the first distance. The antenna assembly includes or is operably coupled to a selector module configured to select one element of the first set of antenna elements as a selected director, and select one element of the second set of antenna elements as a selected reflector by effectively shortening a length of the selected director and effectively lengthening the selected reflector.

Abstract: A network controller including processing circuitry may be configured to receive dynamic position information indicative of a three dimensional position of at least one mobile communication node, compare fixed position information indicative of fixed geographic locations of respective access points of a network to the dynamic position information to determine a relative position of the at least one mobile communication node relative to at least one of the access points based on the fixed position information and the dynamic position information, and provide network control instructions to at least one network asset based on the relative position.

Abstract: A global positioning system (GPS) receiver may include an antenna configured to receive GPS signals from GPS satellites, a radio frequency (RF) front end configured to pre-process signals received by the antenna, a demodulator/converter configured to perform demodulation and analog-to-digital conversion of output signals received from the RF front end, a clock configured to provide a consistent clock signal, and a digital signal processor configured to receive the clock signal and make time and code measurements associated with determining a location of the GPS receiver based on the signals received by the antenna. The GPS receiver may be configured to eliminate reflected or indirect signals from the time and code measurements.

Abstract: In one embodiment, the present disclosure relates to an electrosurgical device that includes an outer body, an inner body disposed partially within the outer body, three plates and an insulator. A first plate of the three plates includes a plurality of apertures and is positioned so that each of two projections extending from the inner body extend through a respective aperture of the plurality of apertures of the first plate. A second plate and a third plate of the three plates are both disposed on the first plate such that each of the two projections extends through an aperture of the second plate or the third plate, the second and third plates being fixed to a respective projection. The insulator is disposed around the inner body and is attached to the outer body at a first end and abuts the first plate at a second end opposite the first end.

Abstract: A drill bit comprises a bit body having a longitudinal axis and a blade extending radially outward from the longitudinal axis along a face region and axially along a gauge region. A gauge region includes a cutting element located proximate to an uphole edge of the blade in the gauge region. A remainder of the gauge region is free of cutting elements mounted thereon. A method of drilling a borehole comprises rotating the bit about the longitudinal axis, engaging a formation with cutting elements mounted to the face region, and increasing a lateral force applied substantially perpendicular to the longitudinal axis such that the cutting element engages the formation and such that side cutting exhibited by the tool is initially minimal and substantially constant and subsequently increases in a substantially linear manner with increasing lateral force.