Patents by Inventor James Hsieh
James Hsieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240154570Abstract: A coupling clamp is provided that includes a top clamp and a bottom clamp. The top clamp may include a top vertical flange and a top lateral flange. The bottom clamp may include a bottom vertical flange and one or more bottom lateral flanges that extend laterally in opposite directions. At least one of the bottom lateral flanges may include a first portion having a surface configured to engage with a solar module and a second portion connected to the bottom vertical flange at an intersection below the surface of the first portion. The coupling clamp may be installed onto one or more solar modules that are positioned onto a rail that has an installed rail clamp. Another solar module may be positioned on the coupling clamp and rail and then slid under the rail clamp, which may be tightened to secure the other solar module to the rail.Type: ApplicationFiled: November 3, 2023Publication date: May 9, 2024Inventors: Erich Kai Stephan, Ian Wogan, Ian Lennox, James Hsieh
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Patent number: 11977052Abstract: Systems and methods for analyzing physical characteristics of a battery include arrangements of two or more transducers coupled to the battery. A control module controls one or more of the two or more transducers to transmit acoustic signals through at least a portion of the battery, and one or more of the two or more transducers to receive response acoustic signals. Distribution of physical properties of the battery is determined based at least on the transmitted acoustic signals and the response acoustic signals.Type: GrantFiled: September 16, 2020Date of Patent: May 7, 2024Assignee: Liminal Insights, Inc.Inventors: Andrew Gaheem Hsieh, Barry James Van Tassell, Daniel Artemis Steingart, Shaurjo Biswas, Robert Charles Mohr
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Publication number: 20230287674Abstract: A splice having a main body and one or more protrusions extending from the main body. The one or more protrusions can be operable to interfere with a rail when the main body is installed into an opening of the rail. The one or more protrusions may be operable to cut into a coating of the rail and form an electrical connection between the rail and the main body.Type: ApplicationFiled: February 14, 2023Publication date: September 14, 2023Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Patent number: 11611310Abstract: A solar mount, for use with a bracket attachment, has an open and a closed state. In the open state, grip flanges on two hinged arms can pass through a slot opening on the bracket attachment. In the closed state, the grip flanges cooperate with respective groves in the bracket attachment to secure the solar mount to the bracket attachment. In the closed state, a fastener attaches a solar accessory, such as a rail, and holds the two hinged arms together. A flexible mount helps hold the two hinged arms together in the open state, and also helps hold the two hinged arms in the closed state.Type: GrantFiled: January 22, 2021Date of Patent: March 21, 2023Assignee: PEGASUS SOLAR INC.Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Patent number: 11608627Abstract: A splice having a main body and one or more protrusions extending from the main body. The one or more protrusions can be operable to interfere with a rail when the main body is installed into an opening of the rail. The one or more protrusions may be operable to cut into a coating of the rail and form an electrical connection between the rail and the main body.Type: GrantFiled: June 7, 2022Date of Patent: March 21, 2023Assignee: PEGASUS SOLAR INC.Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Publication number: 20230052528Abstract: Disclosed herein, inter alia, are compounds and methods for inhibiting Taspase1 and the treatment of cancer.Type: ApplicationFiled: November 20, 2020Publication date: February 16, 2023Inventors: Michelle R. Arkin, R. Jeffrey Neitz, Adam R. Renslo, James Hsieh, Shubhankar Dutta, Clifford Bryant, William J. Moore, Alex G. Waterson, Lidia Sambucetti, Somnath Jana, lan M. Romaine, Alexander P. Lamers, Yassir Younis Adam, Claire Repellin
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Publication number: 20220319638Abstract: Aspects of the disclosure relate to methods, systems, computer-readable storage media, and graphical user interfaces (GUIs) that are useful for characterizing subjects having certain cancers, for example renal cell carcinomas such as clear cell renal carcinoma (ccRCC). The disclosure is based, in part, on methods for determining the renal cancer (RC) tumor microenvironment (TME) type (RC TME type) of a renal cancer subject and the subject's prognosis and/or likelihood of responding to certain therapies (e.g., immunotherapy or tyrosine kinase inhibitors) based upon the renal cancer type determination.Type: ApplicationFiled: March 9, 2022Publication date: October 6, 2022Inventors: James Hsieh, Alexander Bagaev, Natalia Miheecheva, Ekaterina Postovalova, Danil Stupichev, Kristina Perevoshchikova
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Publication number: 20220298776Abstract: A splice having a main body and one or more protrusions extending from the main body. The one or more protrusions can be operable to interfere with a rail when the main body is installed into an opening of the rail. The one or more protrusions may be operable to cut into a coating of the rail and form an electrical connection between the rail and the main body.Type: ApplicationFiled: June 7, 2022Publication date: September 22, 2022Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Publication number: 20220263458Abstract: A u-shaped clamp that includes offset bends at distal ends, accepts a threaded fastener through two apertures, where tightening the fastener brings two flanges of the u-shaped clamp together to grip a wire, a cable or a pipe. An offset bend on one end of one flange serves to hold a wire or cable in position until the fastener is tightened.Type: ApplicationFiled: February 15, 2022Publication date: August 18, 2022Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Publication number: 20220239247Abstract: A solar mount, for use with a bracket attachment, has an open and a closed state. In the open state, grip flanges on two hinged arms can pass through a slot opening on the bracket attachment. In the closed state, the grip flanges cooperate with respective groves in the bracket attachment to secure the solar mount to the bracket attachment. In the closed state, a fastener attaches a solar accessory, such as a rail, and holds the two hinged arms together. A flexible mount helps hold the two hinged arms together in the open state, and also helps hold the two hinged arms in the closed state.Type: ApplicationFiled: January 22, 2021Publication date: July 28, 2022Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Patent number: 11377840Abstract: A splice having a main body and one or more protrusions extending from the main body. The one or more protrusions can be operable to interfere with a rail when the main body is installed into an opening of the rail. The one or more protrusions may be operable to cut into a coating of the rail and form an electrical connection between the rail and the main body.Type: GrantFiled: November 24, 2020Date of Patent: July 5, 2022Assignee: PEGASUS SOLAR INC.Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Publication number: 20220190781Abstract: An electrically conductive bond jumper connects two solar modules, and is affixed to the solar modules with u-shaped spring grips on each end. The spring grips have sharp pointed teeth to penetrate coatings on the solar modules and enhance the electrical connection between the solar modules.Type: ApplicationFiled: December 11, 2020Publication date: June 16, 2022Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Patent number: 11143436Abstract: A clamp particularly designed for use on the end of a solar module mounting rail, includes two hinged parts that can be adjusted by a fastener to clamp a solar module to the rail. A pull-tab with toothed catches helps to position the clamp during installation, and also prevents the clamp from sliding too far into the rail, while a grip body increases friction and electrical contact between the solar module and the clamp.Type: GrantFiled: December 14, 2020Date of Patent: October 12, 2021Assignee: PEGASUS SOLAR, INC.Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Phenylsulfonamido-benzofuran derivatives and uses thereof in the treatment of proliferative diseases
Patent number: 11098021Abstract: Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein.Type: GrantFiled: August 12, 2016Date of Patent: August 24, 2021Assignees: Memorial Sloan-Kettering Cancer Center, Albert Einstein College of Medicine, Inc.Inventors: Emily H. Cheng, Paul Jeng, Ouathek Ouerfelli, James Hsieh, Guangli Yang, Evripidis Gavathiotis -
Publication number: 20210156413Abstract: A twist-lock clamp to attach a solar module to a rail system includes a spring between a top clamp and a t-nut, with features on the spring and top clamp to restrict rotation relative to each other. The t-nut includes features allowing rotation of about 90 degrees when the t-nut is inserted in a rail, but restrict rotation beyond about 90 degrees. The spring serves to hold the top clamp and t-nut apart while allowing the twist-lock clamp to resist sliding in the rail during installation.Type: ApplicationFiled: November 24, 2020Publication date: May 27, 2021Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Publication number: 20210156135Abstract: A splice having a main body and one or more protrusions extending from the main body. The one or more protrusions can be operable to interfere with a rail when the main body is installed into an opening of the rail. The one or more protrusions may be operable to cut into a coating of the rail and form an electrical connection between the rail and the main body.Type: ApplicationFiled: November 24, 2020Publication date: May 27, 2021Inventors: Erich Kai Stephan, Glenn Harris, Peter Wilke, Nicholas Wenzel, James Hsieh
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Phenylsulfonamido-benzofuran derivatives and uses thereof in the treatment of proliferative diseases
Patent number: 10975051Abstract: Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein.Type: GrantFiled: August 12, 2016Date of Patent: April 13, 2021Assignee: Memorial Sloan Kettering Cancer CenterInventors: Emily H. Cheng, Paul Jeng, Ouathek Ouerfelli, James Hsieh, Guangli Yang -
Publication number: 20180335421Abstract: A method of identifying inhibitors of the anti-apoptotic survival pathway in cancer cells is disclosed. The method comprises the steps of (a) exposing cultured wild-type cells to a candidate inhibitor at a predetermined concentratioh for a predetermined period of time and determining cell viability aftet the exposure to the candidate inhibitor; (b) exposing two or more cell lines of specifically MCL-1 or BCL-2 or BCL-X1 addicted cells to the candidate inhibitor at the predetermined concentration for the predetermined period of time and determining cell viability after the exposure to the candidate inhibitor, and (c) indentifying the candidate inhibitor as a MCL-1 or BCL-2 or BCL-X1 inhibitor if the cell viability in step (a) is significantly higher than the cell viability in step (b). The disclosed method provides a way to identify inhibitors which selectively inhibit specific members of the BCL-2 family (e.g.Type: ApplicationFiled: November 18, 2016Publication date: November 22, 2018Applicant: Memorial Sloan-Kettering Cancer CenterInventors: Emily H. Cheng, James Hsieh
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PHENYLSULFONAMIDO-BENZOFURAN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF PROLIFERATIVE DISEASES
Publication number: 20180237406Abstract: Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein.Type: ApplicationFiled: August 12, 2016Publication date: August 23, 2018Applicant: Memorial Sloan-Kettering Cancer CenterInventors: Emily H. Cheng, Paul Jeng, Ouathek Ouerfelli, James Hsieh, Guangli Yang -
PHENYLSULFONAMIDO-BENZOFURAN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF PROLIFERATIVE DISEASES
Publication number: 20180237407Abstract: Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein.Type: ApplicationFiled: August 12, 2016Publication date: August 23, 2018Applicants: Memorial Sloan-Kettering Cancer Center, Albert Einstein College of Medicine, Inc.Inventors: Emily H. Cheng, Paul Jeng, Ouathek Ouerfelli, James Hsieh, Guangli Yang, Evripidis Gavathiotis