Abstract: Calcium 1-hydroxy-3-aminopropane-1,1-diphosphonate forms a gel when mixed with water. As compared to soluble salts of APD, the gel provides slow systemic release and reduced tissue damage when used in the treatment of certain disorders in warm blooded animals.

Abstract: Stable compositions, useful as technetium-99m-based imaging agents, comprise reductic acid or certain structurally-related compounds in combination with a pertechnetate reductant or dissolved in pertechnetate-99m solution. The compositions are especially useful, in combination with a phosphate or phosphonate bone-targeting carrier, for skeletal imaging.

Abstract: Boron containing polyphosphonates of the formula ##STR1## wherein Z is a boron-containing radical; R.sub.2 is an alkyl group containing from 1 to about 10 carbon atoms; R.sub.3 is a geminal diphosphonate or a vicinal polyphosphonate containing up to 10 phosphonic acid radicals; R.sub.4 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, --CH.sub.2 COOH, --CH.sub.2 PO.sub.3 H.sub.2, or --CH.sub.2 CH.sub.2 PO.sub.3 H.sub.2 ; and the salts and esters thereof, have high affinity for calcified tissues, in particular calcific tumors. The compounds are useful in boron neutron capture therapy of such tumors.

Abstract: Oral compositions which contain as a sweetening agent 6-methyloxathiazinone dioxide or an alkali metal or alkaline earth salt thereof in an amount of from about 0.05% to about 0.80%.

Abstract: A dentifrice abrasive coated with a cationic water-soluble polymer which abrasive is thereby made less adsorptive to therapeutic cationic agents, and therapeutic compositions containing said abrasive.

Abstract: A dentifrice abrasive coated with a cationic water-soluble polymer which abrasive is thereby made less adsorptive to therapeutic cationic agents, and therapeutic compositions containing said abrasive.