Patents by Inventor James J. Yoo

James J. Yoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10500384
    Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: December 10, 2019
    Assignee: Wake Forest University Health Sciences
    Inventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Weixin Zhao, Dennis Dice, Tao Xu
  • Patent number: 10493040
    Abstract: A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: December 3, 2019
    Assignee: Wake Forest University Health Sciences
    Inventors: Benjamin S. Harrison, James J. Yoo, Anthony Atala
  • Patent number: 10493041
    Abstract: A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: December 3, 2019
    Assignee: Wake Forest University Health Sciences
    Inventors: Benjamin C. Harrison, James J. Yoo, Anthony Atala
  • Patent number: 10398739
    Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition. The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: September 3, 2019
    Assignee: Wake Forest University Health Sciences
    Inventors: Emmanuel C. Opara, James J. Yoo, Justin M. Saul, Sittadjody Sivanandane, Anthony Atala
  • Publication number: 20190127884
    Abstract: The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and anti-thrombogenic agents on the inner surfaces of their lumens.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 2, 2019
    Inventors: Sang Jin Lee, James J. Yoo, Young Min Ju, Anthony Atala
  • Publication number: 20190038849
    Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.
    Type: Application
    Filed: October 12, 2018
    Publication date: February 7, 2019
    Inventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
  • Publication number: 20190022021
    Abstract: A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.
    Type: Application
    Filed: September 26, 2018
    Publication date: January 24, 2019
    Inventors: Benjamin C. Harrison, James J. Yoo, Anthony Atala
  • Publication number: 20180339084
    Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
    Type: Application
    Filed: February 20, 2018
    Publication date: November 29, 2018
    Inventors: Evangelia Bellas, Kacey Marra, J. Peter Rubin, David L. Kaplan, James J. Yoo
  • Patent number: 10118005
    Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: November 6, 2018
    Assignee: WAKE FOREST UNIVERSITY HEALTH SCIENCES
    Inventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
  • Publication number: 20180280446
    Abstract: The present invention relates to a cell therapy product which is intended for regenerating a sphincter muscle and which contains stem cells derived from amniotic fluid, and more particularly, to a cell therapy product which is intended for regenerating the sphincter vesicae and which contains stem cells derived from amniotic fluid. Also, the cell therapy product of the present invention can be provided in the form of a formulation for administration through injection, said formulation being injected into a hydrogel complex to thereby improve the effects thereof. The composition including stem cells derived from amniotic fluid according to the present invention enables stem cells to be differentiated into muscles in the body of individual suffering from urinary incontinence by directly injecting the composition into the individual, thus effectively controlling urinary incontinence by recovering muscle functions.
    Type: Application
    Filed: April 3, 2018
    Publication date: October 4, 2018
    Inventors: Jeong Ok Lim, Tae Gyun Kwon, So Young Chun, James J. Yoo
  • Patent number: 9931434
    Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: April 3, 2018
    Assignees: Trustees of Tufts College, University of Pittsburgh of the Commonwealth System of Higher Education, Wake Forest University Health Sciences
    Inventors: Evangelia Bellas, Kacey Marra, J. Peter Rubin, David L. Kaplan, James J. Yoo
  • Publication number: 20170368743
    Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
    Type: Application
    Filed: August 9, 2017
    Publication date: December 28, 2017
    Inventors: Hyun-Wook Kang, Sang Jin Lee, Anthony Atala, James J. Yoo
  • Publication number: 20170354763
    Abstract: Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics. Described herein is an artificial mammalian skin substitute product, comprising: (a) optionally, but in some embodiments preferably, a first (“hypodermis-like”) layer comprising live mammalian adipocytes (e.g., induced pre-adipocytes) in a first hydrogel carrier; (b) a second (“dermis-like”) layer contacting or directly contacting the first layer and comprising live mammalian fibroblast cells and' live mammalian follicle dermal papilla cells in combination in a second hydrogel carrier; (c) a third (“epidermis-like”) layer contacting or directly contacting the second layer (i.e.
    Type: Application
    Filed: January 11, 2016
    Publication date: December 14, 2017
    Inventors: Anthony Atala, Gayoung Jeong, James J. Yoo, Sang Jin Lee, Young-Joon Seol
  • Patent number: 9764516
    Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: September 19, 2017
    Assignee: Wake Forest University Health Sciences
    Inventors: Hyun-Wook Kang, Sang Jin Lee, Anthony Atala, James J. Yoo
  • Patent number: 9763986
    Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: September 19, 2017
    Assignee: Wake Forest University Health Sciences
    Inventors: Emmanuel Opara, James J. Yoo, Justin M. Saul, Sittadjody Sivanandane, Anthony Atala
  • Patent number: 9713501
    Abstract: Provided herein is a tissue stretching device configured for orbicular expansion of a tissue placed therein. Methods of use of the device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods making use of the same.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: July 25, 2017
    Assignees: Wake Forest University Health Sciences, North Carolina State University
    Inventors: Rohan A. Shirwaiker, Caroline Elise Webster, John D. Jackson, Richard A. Wysk, Sang Jin Lee, Ola L. A. Harrysson, James J. Yoo, Anthony Atala, Paul H. Cohen, Yuan-Shin Lee, Peter M. Prim, Molly F. Purser, Katie L. Basinger
  • Patent number: 9598704
    Abstract: Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: March 21, 2017
    Assignee: Wake Forest University Health Sciences
    Inventors: Tao Xu, James J. Yoo, Anthony Atala
  • Patent number: 9585688
    Abstract: Provided herein is a tissue stretching device including a tissue clamping member defining an area in a Z plane, wherein the tissue clamping member is configured to hold tissue parallel to the Z plane. Methods of use of the tissue stretching device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods of treatment making use of the same.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: March 7, 2017
    Assignee: Wake Forest University Health Sciences
    Inventors: James J. Yoo, Anthony Atala, Paul Scarpinato, Sang Jin Lee, Mitchell Ladd
  • Patent number: 9580688
    Abstract: Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein cells have been expanded in vitro, and methods of use thereof. The cells may be provided in a three dimensional matrix for culturing in vitro and/or implanting in vivo. Methods of seeding cells onto the matrix are also provided.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: February 28, 2017
    Assignee: Wake Forest University Health Sciences
    Inventors: Anthony Atala, James J. Yoo
  • Patent number: 9534203
    Abstract: Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein cells have been expanded in vitro. The kidney cells may include peritubular interstitial cells of the kidney, and preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells produce EPO in vivo.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: January 3, 2017
    Assignee: Wake Forest University Health Sciences
    Inventors: Anthony Atala, James J. Yoo