Patents by Inventor James J. Yoo
James J. Yoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160166620Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition. The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.Type: ApplicationFiled: September 2, 2014Publication date: June 16, 2016Inventors: Emmanuel C. Opara, James J. Yoo, Justin M. Saul, Sittadjody Sivanandane, Anthony Atala
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Patent number: 9301925Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.Type: GrantFiled: March 11, 2015Date of Patent: April 5, 2016Assignee: Wake Forest University Health SciencesInventors: Tao Xu, James J. Yoo, Anthony Atala
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Patent number: 9283251Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.Type: GrantFiled: February 21, 2012Date of Patent: March 15, 2016Assignee: Wake Forest University Health SciencesInventors: Emmanuel Opara, James J. Yoo, Justin M. Saul, Sittadjody Sivanandane, Anthony Atala
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Publication number: 20160002603Abstract: Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein cells have been expanded in vitro. The kidney cells may include peritubular interstitial cells of the kidney, and preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells produce EPO in vivo.Type: ApplicationFiled: September 16, 2015Publication date: January 7, 2016Inventors: Anthony Atala, James J. Yoo
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Publication number: 20150299730Abstract: Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.Type: ApplicationFiled: April 28, 2015Publication date: October 22, 2015Inventors: Tao Xu, James J. Yoo, Anthony Atala
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Publication number: 20150196604Abstract: The present invention relates to a cell therapy product which is intended for regenerating a sphincter muscle and which contains stem cells derived from amniotic fluid, and more particularly, to a cell therapy product which is intended for regenerating the sphincter vesicae and which contains stem cells derived from amniotic fluid. Also, the cell therapy product of the present invention can be provided in the form of a formulation for administration through injection, said formulation being injected into a hydrogel complex to thereby improve the effects thereof. The composition including stem cells derived from amniotic fluid according to the present invention enables stem cells to be differentiated into muscles in the body of individual suffering from urinary incontinence by directly injecting the composition into the individual, thus effectively controlling urinary incontinence by recovering muscle functions.Type: ApplicationFiled: January 5, 2015Publication date: July 16, 2015Inventors: Jeong Ok Lim, Tae Gyun Kwon, So Young Chun, James J. Yoo
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Publication number: 20150182471Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.Type: ApplicationFiled: March 11, 2015Publication date: July 2, 2015Inventors: Tao Xu, James J. Yoo, Anthony Atala
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Patent number: 9045757Abstract: Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.Type: GrantFiled: June 6, 2008Date of Patent: June 2, 2015Assignee: Wake Forest University Health SciencesInventors: Tao Xu, James J. Yoo, Anthony Atala
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Patent number: 9039782Abstract: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.Type: GrantFiled: April 18, 2014Date of Patent: May 26, 2015Assignee: Wake Forest University Health SciencesInventors: Anthony Atala, James J. Yoo, Grace Lim, Sang Jin Lee
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Publication number: 20150119994Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.Type: ApplicationFiled: September 3, 2014Publication date: April 30, 2015Inventors: Hyun-Wook Kang, Sang Jin Lee, Anthony Atala, James J. Yoo
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Patent number: 9005972Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.Type: GrantFiled: February 20, 2014Date of Patent: April 14, 2015Assignee: Wake Forest University Health SciencesInventors: Tao Xu, James J. Yoo, Anthony Atala, Dennis Dice
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Publication number: 20150018948Abstract: Provided herein is a tissue stretching device configured for orbicular expansion of a tissue placed therein. Methods of use of the device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods making use of the same.Type: ApplicationFiled: July 8, 2014Publication date: January 15, 2015Inventors: Rohan A. Shirwaiker, Caroline Elsie Webster, John D. Jackson, Richard A. Wysk, Sang Jin Lee, Ola L.A. Harrysson, James J. Yoo, Anthony Atala, Paul H. Cohen, Yuan-Shin Lee, Peter M. Prim, Molly F. Purser, Katie L. Basinger
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Publication number: 20140371869Abstract: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.Type: ApplicationFiled: April 18, 2014Publication date: December 18, 2014Applicant: Wake Forest University Health SciencesInventors: Anthony Atala, James J. Yoo, Grace Lim, Sang Jin Lee
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Patent number: 8883190Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. Kits comprising the same are also provided.Type: GrantFiled: November 30, 2007Date of Patent: November 11, 2014Assignee: Wake Forest University Health SciencesInventors: Steve J. Hodges, Anthony Atala, James J. Yoo
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Patent number: 8883183Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is an absorbable esophageal or tracheal stent. In some embodiments, the device is a vascular stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. An ointment comprising a collagen inhibitor is further provided. Kits comprising the coated substrates are also provided.Type: GrantFiled: May 30, 2008Date of Patent: November 11, 2014Assignee: Wake Forest University Health SciencesInventors: Christopher A. Sullivan, Steve J. Hodges, Anthony Atala, James J. Yoo
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Publication number: 20140199276Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.Type: ApplicationFiled: February 20, 2014Publication date: July 17, 2014Applicant: Wake Forest University Health SciencesInventors: Tao Xu, James J. Yoo, Anthony Atala, Dennis Dice
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Publication number: 20140127308Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.Type: ApplicationFiled: February 21, 2012Publication date: May 8, 2014Applicant: Wake Forest University Health SciencesInventors: Emmanuel Opara, James J. Yoo, Justin M. Saul, Sittadjody Sivanandane, Anthony Atala
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Publication number: 20140128416Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. In some embodiments, the device is an absorbable esophageal or tracheal stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. Kits comprising the coated substrates are also provided.Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Applicant: Wake Forest University Health SciencesInventors: Christopher A. Sullivan, Steve J. Hodges, Anthony Atala, James J. Yoo
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Patent number: 8691274Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.Type: GrantFiled: February 13, 2009Date of Patent: April 8, 2014Assignee: Wake Forest University Health SciencesInventors: Tao Xu, James J. Yoo, Anthony Atala, Dennis Dice
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Patent number: 8668703Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. In some embodiments, the device is an absorbable esophageal or tracheal stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. Kits comprising the coated substrates are also provided.Type: GrantFiled: November 30, 2007Date of Patent: March 11, 2014Assignee: Wake Forest University Health SciencesInventors: Christopher A. Sullivan, Steve J. Hodges, Anthony Atala, James J. Yoo