Abstract: The invention provides heterobifunctional compounds comprising an effector protein binding moiety selected from mTor, PLK1, CDKI, CDK2, CDK9, BRD4, AURKA, AURKB, MEK, Src, c-KIT, KIF11, HSP90, tubulin, proteasome, topoisomerase or HD AC which is linked to a moiety that binds to a target protein selected from KRAS, HER2 or EGFR. Pharmaceutical compositions and their use in treating disease, such as cancer, are also disclosed.

Abstract: The invention provides heterobifunctional compounds, pharmaceutical compositions, and their use treating disease, such as cancer.

Abstract: A dustcap comprises a body having a cylindrical portion configured to receive a ferrule of an optical fiber connector, and an end portion opposite the cylindrical portion. The end portion includes a receptacle. The dustcap has a built-in cleaner disposed within the receptacle. The dustcap further comprises a removable cover configured to couple to the end portion of the dustcap. In another embodiment, the end portion includes a flat surface, the cleaner is disposed on the flat surface of the end portion, and the cover is configured to receive the end portion of the dustcap. In another embodiment, the cover has a receptacle and the cleaner is disposed within the receptacle, whereas the body comprises an end portion configured to receive at least a portion of the cover with the built-in cleaner. Embodiments encompass cleaner assemblies and adapter dustcaps having built-in cleaners.

Abstract: A flexible optical fiber connector comprises a first housing component configured to couple to a terminating connector, and a second housing component configured to receive an optical fiber for termination in the terminating connector. The first housing component and the second housing component are further configured to receive a pushable connector therethrough. A flexible optical fiber connector assembly comprises a flexible connector and a terminating connector coupled thereto. The flexible connector assembly is configured to couple to an adapter held by a holder coupled to a port.

Abstract: An optical fiber ribbon may be intermittently bonded with a repeating pattern of bond lengths and gap lengths configured to enhance flexibility and robustness of the optical fiber ribbon. The ribbon may include a plurality of optical fibers where a first adjacent two of the optical fibers may be intermittently connected together by the bond portions arranged in a longitudinal pattern which may have a constant bond length or may have a constant distance between bond portions. A second adjacent two of the optical fibers may be intermittently connected together by the bond portions arranged in the longitudinal pattern where a first bond portion of the second adjacent two of the optical fibers may be offset from the first bond portion of the first adjacent two of the optical fibers in the longitudinal direction by a first offset length (O1).

Abstract: Embodiment herein relate to a neural network compression technique, in which a weight matrix within the neural network is transformed via matrix multiplication with an orthogonal matrix. The orthogonal matrix is derived from a calibration dataset (which is generally chosen to be broadly representative of expected runtime input data), and the transformation is such that a resulting modified weight matrix has components ordered by relative significance. The modified weight matrix is incorporated in a compressed neural network with fewer weights. By removing one or more components of lower significance, the size of the neural network (and, therefore, its storage and execution overhead) are reduced, whilst still maintaining an acceptable level of performance.

Abstract: A dispenser includes a front panel that can be opaque, and a body that includes a sidewall extending from a rear wall. Further, the front panel is coupled to the body and an interior cavity is formed therebetween. The sidewall includes an illuminating portion and a viewing portion. The illuminating portion is translucent and the viewing portion is transparent. The viewing portion is located between the front panel and the rear wall and the viewing portion and the illuminating portion indicate a refill status.

Abstract: A gummy includes an inner portion, a formulation having a dispersion including an active ingredient contained in the inner portion; and an outer portion which surrounds the inner portion. The active ingredient includes one or more nutrients such as cannabinoids and dietary supplement. The dispersion includes one or more of a liposome emulsion; a nanoemulsion, and a microemulsion, each containing the active ingredient. A method of making such gummy having the cannabinoids and/or dietary supplement formulation in the inner portion thereof includes setting up a central filling apparatus having a shell syrup hopper, a central filling hopper, and a manifold branch and nozzle mechanism; filling the shell syrup hopper with the base material; filling the central filling hopper with the formulation; dispensing the base material and the formulation in the manifold branch and nozzle mechanism, and further into the gummy mold; and extracting the gummy from the gummy mold.

Abstract: Multi-conductor ribbon structures may be structurally configured to reduce cable installation time. Such ribbon structures may include an adjacent conductor portion and a bonding portion that may be structurally configured to surround at least a conductor portion of the adjacent conductor portion. The adjacent conductor portion may be partially or wholly surrounded by a coating portion having an outer surface portion. The bonding portion may form a separation portion between the outer surface of each of the adjacent conductors. The separation portion may include a reduced amount of the bonding material adjacent to a first portion of the adjacent conductor portion relative to an amount of the bonding material portion adjacent a second portion of the adjacent conductor portion so as to provide a preferential separation region between the adjacent conductor portion at the first portion of the adjacent conductor portion.

Abstract: The present disclosure relates to apparatus for covering wheel components, and related wheel modules and vehicles. In one or more embodiments, a wheel module includes a wheel component including a plurality of wheel openings, and a cover frame. The cover frame includes a plurality of openings, and a plurality of divider sections at least partially dividing the plurality of openings. The wheel module includes an actuation system configured to rotationally drive the cover frame relative to the wheel component in response to centrifugal force to at least partially cover the wheel opening. The wheel module includes a retraction spring configured to bias the cover frame to rotationally drive the cover frame relative to the wheel component to at least partially uncover the wheel openings.

Abstract: The present invention relates to analgesic treatments to reduce pain through use of an inhibitor of fatty-acid amide hydrolase pseudogene (FAAH-OUT).

Abstract: A dustcap comprises a body having a cylindrical portion configured to receive an optical fiber connector ferrule, and an end portion opposite the cylindrical portion. The end portion includes a side-facing receptacle. The dustcap has a built-in cleaner disposed within the side-facing receptacle. The dustcap further comprises a removable cover configured to couple to the end portion of the dustcap. In another example implementation, the end portion includes a flat surface, the cleaner is disposed on the flat surface of the end portion, and the cover is configured to receive the end portion of the dustcap. In another example implementation, the cover has a receptacle, and the cleaner is disposed within the receptacle, whereas the body comprises an end portion configured to receive at least a portion of the cover with the built-in cleaner. Example implementations encompass adapter dustcaps and adapter dustcap assemblies having built-in cleaners and alignment portions.

Abstract: An apparatus and methodology for a back end of line (BEOL) structure in an integrated circuit (IC) die, includes a first BEOL structure layer having a first plurality of self-referential marking features disposed a first distance from a substrate of the IC die in a predefined two-dimensional (2D) arrangement. A second BEOL structure layer has a second plurality of the self-referential marking features a second distance from the substrate in a predefined 2D arrangement. The first and second pluralities of marking features collectively form a three-dimensional (3D) BEOL identifier (3D BEOL ID) self-referencing the IC die.

Abstract: Embodiments include an ingestible capsule comprising a housing including a therapeutic payload carrying compartment; a power supply; a release mechanism; and a sensing mechanism, the sensing mechanism being sensitive to an environment external to the housing; the ingestible capsule being configured for passage through a GI tract of a subject mammal, during which passage: the sensing mechanism is configured to output a signal varying according to a GI tract environment, wherein the sensing mechanism comprises one or more sensors from among: a VOC gas sensor; a TCD gas sensor; a reflectometer formed by a transmission antenna of the ingestible capsule connected in series with a directional coupler configured to measure a reflected signal from the transmission antenna; and an accelerometer; the release mechanism is configured to cause a therapeutic payload to be released into the GI tract from the therapeutic payload carrying compartment at a release timing determined according to the output signal.

Abstract: Techniques for enhanced calibration and performance of quantum computers are presented. A monitoring job component can execute monitoring jobs on a quantum computer. A modeler component can determine respective quantum computer system state parameter values at a given time based on parameter values at respective time instances, the parameter values determined from output data generated by the quantum computer in response to execution of the monitoring jobs. A calibration agent can determine a calibration strategy relating to ordering of performance of calibration tasks to calibrate at least one parameter associated with the quantum computer based on the quantum computer system state parameter values.

Abstract: An oral care composition includes hops beta acid, a stannous ion source, a monodentate ligand, and one or more polydentate ligands. The oral care composition may have an improved soluble stannous concentration.

Abstract: A dispenser includes a front panel that can be opaque, and a body that includes a sidewall extending from a rear wall. Further, the front panel is coupled to the body and an interior cavity is formed therebetween. The sidewall includes an illuminating portion and a viewing portion. The illuminating portion is translucent and the viewing portion is transparent. The viewing portion is located between the front panel and the rear wall and the viewing portion and the illuminating portion indicate a refill status.

Abstract: A fiber optic furcation assembly can include a fan-out structure. The fan out structure can include a conduit, and the conduit can extend from a first face of the fan-out structure to an opposing second face of the fan-out structure. The fiber optic furcation assembly can also include a furcation tube. The furcation tube can be positioned within the conduit, and the furcation tube can extend to a terminal end beyond the second face of the fan-out structure. The fiber optic furcation assembly can also include a fiber pull. The fiber pull can be positioned within the furcation tube, and the fiber pull can protrude in a first portion beyond the first face of the fan-out structure and the fiber pull can protrude in a second portion beyond the terminal end of the furcation tube, and the fiber optic furcation assembly can also include an attachment structure. The attachment structure can be fixed to the first portion of the fiber pull, and the attachment structure can receive and couple with an optical fiber.

Abstract: A fault injection system for a cloud infrastructure utilizes fault injection agents instantiated on components of the cloud infrastructure to inject fault into the components. The faults are based on fault definitions which define the type(s) of fault(s) to inject, the scope for injecting the fault into the cloud infrastructure, deployment information for deploying the fault in the cloud, and remediation information which defines a plan for remediating the fault in the cloud infrastructure. The system monitors the impact of faults on the components which enables component dependencies to be determined.