Patents by Inventor James L. Brown

James L. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10364909
    Abstract: A fluid flow control device includes a resilient substrate translatable between a first flattened position and a second extended position, and an actuator attached to the resilient substrate. The actuator is configured for translating the resilient substrate from the first flattened position to the second extended position. The actuator is formed from a shape memory alloy transitionable between a first state and a second state in response to a change in temperature of the shape memory alloy. A fluid flow control system includes a rotor shield and the fluid flow control device attached to the rotor shield.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: July 30, 2019
    Assignees: GM Global Technology Operations LLC, Dynalloy, Inc.
    Inventors: Richard J. Skurkis, Paul W. Alexander, Anthony L. Smith, James H. Brown, Tyler P. Ownby, Xiujie Gao
  • Patent number: 10088481
    Abstract: The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: October 2, 2018
    Assignee: Diagnostic Hybrids, Inc.
    Inventors: David R. Scholl, James L. Brown, Joseph A. Jollick, Jr., Ronald Lollar
  • Patent number: 10041943
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: August 7, 2018
    Assignee: Diagnostic Hybrids, Inc.
    Inventor: James L Brown
  • Publication number: 20180100855
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
    Type: Application
    Filed: September 26, 2017
    Publication date: April 12, 2018
    Inventors: Leonard Kohn, James L. Brown, David R. Scholl, Yunsheng Li, Giorgio Napolitano
  • Publication number: 20180052159
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
    Type: Application
    Filed: August 21, 2017
    Publication date: February 22, 2018
    Inventor: James L. Brown
  • Patent number: 9739775
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: August 22, 2017
    Assignee: Diagnostic Hybrids, Inc.
    Inventor: James L. Brown
  • Publication number: 20150301042
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
    Type: Application
    Filed: December 1, 2014
    Publication date: October 22, 2015
    Inventor: James L. Brown
  • Publication number: 20150192584
    Abstract: The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.
    Type: Application
    Filed: January 21, 2015
    Publication date: July 9, 2015
    Inventors: David R. Scholl, James L. Brown, Joseph A. Jollick, JR., Ronald Lollar
  • Patent number: 8975016
    Abstract: The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: March 10, 2015
    Assignee: Diagnostic Hybrids, Inc.
    Inventors: David R. Scholl, James L. Brown, Joseph A. Jollick, Jr., Ronald Lollar
  • Patent number: 8926981
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: January 6, 2015
    Assignee: Diagnostic Hybrids, Inc.
    Inventor: James L. Brown
  • Patent number: 8725470
    Abstract: A method and associated system for multi-disciplinary optimization of various parameters associated with a space vehicle that experiences aerocapture and atmospheric entry in a specified atmosphere. In one embodiment, simultaneous maximization of a ratio of landed payload to vehicle atmospheric entry mass, maximization of fluid flow distance before flow separation from vehicle, and minimization of heat transfer to the vehicle are performed with respect to vehicle surface geometric parameters, and aerostructure and aerothermal vehicle response for the vehicle moving along a specified trajectory. A Pareto Optimal set of superior performance parameters is identified.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: May 13, 2014
    Assignee: The United States of America as Represented by the Administrator of the National Aeronautics & Space Administration (NASA)
    Inventors: James L. Brown, Joseph A Garcia, David J. Kinney, Jeffrey V Bowles, Nagi N Mansour
  • Publication number: 20130167328
    Abstract: A device(10) which protects an object such as a pair of eyeglasses (G) from being damaged by accidentally or inadvertently falling out a person's shirt pocket (S) or pants' pocket (P). The device comprises a first clip (12) which grips a portion of the eyeglass' frame such as the sidepiece (E) that fits over an ear. The device further includes a second clip (14) which clips onto the cloth of the pocket. Since the eyeglasses are now clipped to a pocket, they are not, and cannot be, readily dislodged and so will not fall out of the pocket when a person leans or bends over.
    Type: Application
    Filed: December 28, 2011
    Publication date: July 4, 2013
    Inventor: James L. Brown
  • Publication number: 20130059312
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
    Type: Application
    Filed: September 12, 2012
    Publication date: March 7, 2013
    Inventor: James L. Brown
  • Patent number: 8293879
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: October 23, 2012
    Assignee: Diagnostic Hybrids, Inc.
    Inventor: James L. Brown
  • Publication number: 20120003627
    Abstract: The present invention describes a device for performing a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The device also includes a compatible slide comprising sample wells. The device detects emitted fluorescence signal through a camera and optics assembly that is controlled by a user interface assembly.
    Type: Application
    Filed: June 23, 2011
    Publication date: January 5, 2012
    Inventors: David R. Scholl, James L. Brown, Joseph A. Jollick, JR., Ronald H. Lollar, Brooke B. McCutchan
  • Publication number: 20110269117
    Abstract: The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.
    Type: Application
    Filed: June 22, 2011
    Publication date: November 3, 2011
    Inventors: David R. Scholl, James L. Brown, Joseph A. Jollick, JR., Ronald Lollar
  • Patent number: 8003314
    Abstract: The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: August 23, 2011
    Assignee: Diagnostic Hybrids, Inc.
    Inventors: David R. Scholl, James L. Brown, Joseph A. Jollick, Jr., Ronald Lollar
  • Publication number: 20100261153
    Abstract: The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.
    Type: Application
    Filed: April 16, 2009
    Publication date: October 14, 2010
    Inventors: David R. Scholl, James L. Brown, Joseph A. Jollick, JR., Ronald Lollar
  • Patent number: 7597113
    Abstract: Improvements in present day fire hydrants are presented. The improvement relates to a fire hydrant where the above ground structure is essentially removed and is replaced with an adaptable connection. The connection uses the same mounting hole pattern as used in the above ground hydrant. In operation, the adaptable connection is protected by a hinged cover that is opened to provide access to the adaptable connection. The adaptable connection includes a bayonet type connection where a portable fire hydrant is secured and rotated to start the flow of water. The adapter includes an electronic communication device that transmits real-time information on connection and flow characteristics. The adaptable fire connection eliminates the appearance of the fire hydrant, the potential of a vehicle hitting a fire hydrant and the material cost associated with above ground fire hydrants.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: October 6, 2009
    Inventors: Rodolfo Garcia, James L. Brown
  • Publication number: 20090133887
    Abstract: Improvements in present day fire hydrants are presented. The improvement relates to a fire hydrant where the above ground structure is essentially removed and is replaced with an adaptable connection. The connection uses the same mounting hole pattern as used in the above ground hydrant. In operation, the adaptable connection is protected by a hinged cover that is opened to provide access to the adaptable connection. The adaptable connection includes a bayonet type connection where a portable fire hydrant is secured and rotated to start the flow of water. The adapter includes an electronic communication device that transmits real-time information on connection and flow characteristics. The adaptable fire connection eliminates the appearance of the fire hydrant, the potential of a vehicle hitting a fire hydrant and the material cost associated with above ground fire hydrants.
    Type: Application
    Filed: December 30, 2008
    Publication date: May 28, 2009
    Inventors: RODOLFO GARCIA, JAMES L. BROWN