Patents by Inventor James L. Cook

James L. Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160088833
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 31, 2016
    Applicants: The Curators of the University of Missouri, The Trustees of Columbia University in the City of New York
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Publication number: 20160074151
    Abstract: A graft-positioning system that includes a body further comprising a shaft, a handle engaged to the first end of the shaft, a guide rest engaged to the second end of the shaft and a flange engaged to the guide. In addition, the shaft also includes a plurality of pin channels that extend from the first end to the second end of the shaft. The graft-positioning system may also include plurality of guide pins that are configured and arranged to be received within the plurality of pin channels. Additional embodiments provide an arthroscopic cutter that includes a tubular body and a drive shaft attached to a cutting head at one end and situated within a lumen defined within the tubular body. The tubular body further includes a guide rest engaged to the distal end of the tubular body and a flange engaged to the guide rest.
    Type: Application
    Filed: May 5, 2014
    Publication date: March 17, 2016
    Applicant: The Curators of the University of Missouri
    Inventors: Ferris M. Pfeiffer, Matthew J. Smith, James L. Cook
  • Patent number: 9220258
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: December 29, 2015
    Assignees: The Curators of the University of Missouri, The Trustees of Columbia University in the City of New York
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Publication number: 20150297351
    Abstract: Instrumentation and assembly for arthroscopic elbow surgery which includes a humeral component. The humeral component is installed in a trough formed in the humeral condyle. The trough may be formed by using a plurality of drill pins and a plurality of corresponding cutters (and optionally a template). The two drill pins are passed through the template and drilled into the humerus, and cutters are advanced over the corresponding drill pins to form the trough. The humeral component may be employed in conjunction with an ulnar implant.
    Type: Application
    Filed: July 2, 2015
    Publication date: October 22, 2015
    Inventors: G. Joshua Karnes, James L. Cook, Kurt S. Schulz
  • Patent number: 9089433
    Abstract: Instrumentation and assembly for arthroscopic elbow surgery which includes a humeral component. The humeral component is installed in a trough formed in the humeral condyle. The trough may be formed by using a plurality of drill pins and a plurality of corresponding cutters (and optionally a template). The two drill pins are passed through the template and drilled into the humerus, and cutters are advanced over the corresponding drill pins to form the trough. The humeral component may be employed in conjunction with an ulnar implant.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: July 28, 2015
    Assignee: Arthrex, Inc.
    Inventors: G. Joshua Karnes, James L. Cook, Kurt S. Schulz
  • Publication number: 20150127011
    Abstract: A TPLO plate configured to accommodate flexible strands (flexible loops) attached to tissue to be attached to bone. The TPLO plate has one or more suture eyelets, to allow the user (surgeon) to pass a flexible strand through the eyelets and attach/reattach the tissue to the plate at the anatomical location, and to improve the rotational stability of the joint or bone. The eyelets may have various shapes, forms and configurations and may be provided on or within a surface of the TPLO bone plate in any number, depending on the characteristics of the fractured bone or bone segments, or of the plate design. The eyelets preferably receive one or more flexible strands.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 7, 2015
    Inventors: James R. Dunlop, Gregory Joshua Karnes, Brandon L. Roller, Antonio Pozzi, James L. Cook
  • Publication number: 20140180414
    Abstract: Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate cutting members may define a cutting surface at a distal end of the elongate housing. The cutting surface may be adapted to contract from a first diameter to a second diameter that is less than the first diameter. The contraction of the cutting surface from the first diameter to the second diameter may define a tapered profile between the first diameter and the second diameter suitable for obtaining a tapered graft.
    Type: Application
    Filed: December 10, 2013
    Publication date: June 26, 2014
    Applicant: The Curators of The University of Missouri
    Inventors: Ferris M. Pfeiffer, Aaron M. Stoker, James L. Cook
  • Publication number: 20140155499
    Abstract: Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.
    Type: Application
    Filed: February 7, 2014
    Publication date: June 5, 2014
    Inventors: James L. Cook, Cristi R. Cook, Aaron M. Stoker, Keiichi Kuroki, Bridget Colleen Garner, Richard Evans, Brandon Lee Roller, Prakash Sidha Jayabalan
  • Publication number: 20140091491
    Abstract: Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.
    Type: Application
    Filed: December 12, 2013
    Publication date: April 3, 2014
    Applicants: The Trustees of Columbia University in the City of New York, THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Clark T. Hung, Gerard A. Ateshian, Eric G. Lima, James L. Cook, Li Ming Bian
  • Publication number: 20140081399
    Abstract: An adjustable, knotless button/loop/needle construct for fixation of cranial cruciate ligament deficient stifle. The adjustable, knotless construct includes two fixation devices (for example, two buttons) and at least one flexible, adjustable loop attached to at least one of the fixation devices (e.g., the buttons). Preferably, a needle is attached to each of the fixation devices (e.g., the buttons). The adjustable, knotless construct has an adjustable loop length and allows adjustment in one direction while preventing or locking the construct from loosening in the opposite direction, due to applied tensile forces. The construct and technique of the present invention provides an improved knotless system for cruciate ligament repair.
    Type: Application
    Filed: November 25, 2013
    Publication date: March 20, 2014
    Applicant: Arthrex, Inc.
    Inventors: Brandon L. Roller, Eric S. Zajac, Ricardo Albertorio, James L. Cook
  • Patent number: 8628573
    Abstract: An adjustable, knotless button/loop/needle construct for fixation of cranial cruciate ligament deficient stifle. The adjustable, knotless construct includes two fixation devices (for example, two buttons), at least one flexible, adjustable loop attached to at least one of the fixation devices (e.g., the buttons), and two needles (each needle being attached to one fixation device, e.g., the buttons). The adjustable, knotless construct has an adjustable loop length and allows adjustment in one direction while preventing or locking the construct from loosening in the opposite direction, due to applied tensile forces. The construct and technique of the present invention provides an improved knotless system for cruciate ligament repair.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: January 14, 2014
    Assignee: Arthrex, Inc.
    Inventors: Brandon L. Roller, Eric S. Zajac, Ricardo Albertorio, James L. Cook
  • Publication number: 20130338792
    Abstract: Techniques, mixtures, mixing and delivery kits, and improved delivery instruments for implantation of micronized allograft tissue over a microfractured defect. Allograft cartilage tissue is delivered over a cartilage defect that has been debrided and microfractured, without the need for a periosteal covering or separate type of patch sewn over the top. The allograft tissue may be any micronized cartilage particulates obtained by various methods, for example, cartilage delivered in its native form, dehydrated via lyophilization, “freeze-dried,” dehydrated via desiccation, or dehydrated by any other method.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 19, 2013
    Inventors: Reinhold Schmieding, Brandon L. Roller, David O. Shepard, G. Joshua Karnes, Robert Benedict, Tithi Dutta Roy, Brian J. Cole, James P. Bradley, Eric Giza, James L. Cook, Lisa A. Fortier
  • Patent number: 8608801
    Abstract: Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: December 17, 2013
    Assignees: The Trustees of Columbia University in the City of New York, The Curators of the University of Missouri
    Inventors: Clark T. Hung, Gerard A. Ateshian, Eric G. Lima, James L. Cook, Li Ming Bian
  • Publication number: 20130268082
    Abstract: Instrumentation and assembly for arthroscopic elbow surgery which includes a humeral component. The humeral component is installed in a trough formed in the humeral condyle. The trough may be formed by using a plurality of drill pins and a plurality of corresponding cutters (and optionally a template). The two drill pins are passed through the template and drilled into the humerus, and cutters are advanced over the corresponding drill pins to form the trough. The humeral component may be employed in conjunction with an ulnar implant.
    Type: Application
    Filed: June 6, 2013
    Publication date: October 10, 2013
    Inventors: G. Joshua Karnes, James L. Cook, Kurt S. Schulz
  • Patent number: 8475534
    Abstract: Methods and instrumentation for arthroscopic elbow surgery which include a humeral component. The humeral component is installed in a trough formed in the humeral condyle. The trough may be formed by using a plurality of drill pins and a plurality of corresponding cutters (and optionally a template). The two drill pins are passed through the template and drilled into the humerus, and cutters are advanced over the corresponding drill pins to form the trough. The humeral component may be employed in conjunction with an ulnar implant.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: July 2, 2013
    Assignee: Arthrex, Inc.
    Inventors: Gregory J. Karnes, James L. Cook, Kurt S. Schulz
  • Patent number: 8465521
    Abstract: A suture needle construct and method for extracapsular ligament reconstruction in mammals. The joint is first is first explored, and the damaged ligament and meniscus are debrided. The joint capsule is closed and a tunnel is created at the appropriate location in the proximal tibia for tibial fixation. Subsequent to the formation of the tibial tunnel, a suture having a substantially curved needle at one end and a substantially straight needle at the other end is brought in the proximity of the joint. The suture is passed around the lateral fabella using the substantially curved needle, then deep to the patellar ligament using the substantially straight needle, and through the tibial tunnel using the straight needle. The needles are cut off, and the sutures are tensioned over repair site.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: June 18, 2013
    Assignee: Arthrex, Inc.
    Inventors: James L. Cook, David O. Shepard, Matthew C. Summitt
  • Publication number: 20120177615
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Application
    Filed: January 12, 2012
    Publication date: July 12, 2012
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Patent number: 8202298
    Abstract: An apparatus and method for stabilization of a cranial cruciate ligament deficient stifle in canines using a suture-button construct.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: June 19, 2012
    Assignee: Arthrex, Inc.
    Inventors: James L. Cook, David O. Shepard, Anthony Orozco
  • Publication number: 20110218116
    Abstract: Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, IL6, MMP1, RANTES, MMP9, IL1B, Apolipoprotein A1, Apolipoprotein E, DCN, CILP and COMP. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.
    Type: Application
    Filed: March 4, 2011
    Publication date: September 8, 2011
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: James L. Cook, Cristi R. Cook, Aaron M. Stoker, Keiichi Kuroki, Bridget Colleen Garner, Richard Evans, Brandon Lee Roller, Prakash Sidha Jayabalan
  • Publication number: 20110118781
    Abstract: An apparatus and method for stabilization of a cranial cruciate ligament deficient stifle in canines using a suture-button construct.
    Type: Application
    Filed: January 24, 2011
    Publication date: May 19, 2011
    Inventors: James L. Cook, David O. Shepard, Anthony Orozco