Patents by Inventor James L. Hedrick

James L. Hedrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIMICROBIAL IONENE COMPOSITIONS WITH A VARIETY OF FUNCTIONAL GROUPS
    Publication number: 20190174754
    Abstract: Techniques regarding amine monomers that can form ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments described herein can comprise a monomer, which can comprise a molecular backbone. The molecular backbone can comprise a norspermidine structure. The norspermidine structure can comprise a tertiary amino group. Also, the tertiary amino group can comprise a functional group, and an amino group of the norspermidine structure can be capable of being ionized.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 13, 2019
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • POLYHEMIAMINAL AND POLYHEXAHYDROTRIAZINE MATERIALS FROM 1,4 CONJUGATE ADDITION REACTIONS
    Publication number: 20190177481
    Abstract: Polyhemiaminal (PHA) and polyhexahydrotriazine (PHT) materials are modified by 1,4 conjugate addition chemical reactions to produce a variety of molecular architectures comprising pendant groups and bridging segments. The materials are formed by a method that includes heating a mixture comprising solvent(s), paraformaldehyde, aromatic amine groups, aliphatic amine Michael donors, and Michael acceptors, such as acrylates. The reaction mixtures may be used to prepare polymer pre-impregnated materials and composites containing PHT matrix resin.
    Type: Application
    Filed: February 13, 2019
    Publication date: June 13, 2019
    Inventors: Dylan J. BODAY, Mareva FEVRE, Jeannette M. GARCIA, James L. HEDRICK, Rudy J. WOJTECKI
  • POLYMERS WITH ANTIMICROBIAL FUNCTIONALITIES
    Publication number: 20190174756
    Abstract: Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 13, 2019
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • CHEMICAL COMPOUNDS WITH PERFLUOROARYL GROUPS THAT CAN FACILITATE POST-SYNTHESIS FUNCTIONALIZATION
    Publication number: 20190177466
    Abstract: Techniques regarding chemical compounds comprising perfluoroaryl groups that can facilitate post-synthesis functionalization are provided. For example, one or more embodiments described herein can comprise a chemical compound. The chemical compound can comprise a molecular backbone. The chemical compound can also comprise a pendent functional group bonded to the molecular backbone. The pendent functional group can comprise a perfluoroaryl group and a methylene group.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 13, 2019
    Inventors: James L. Hedrick, Nathaniel H. Park, Gavin Jones
  • ANTIMICROBIAL POLYMERS CAPABLE OF SUPRAMOLECULAR ASSEMBLY
    Publication number: 20190174747
    Abstract: Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 13, 2019
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Yi Yan Yang
  • Method of making highly porous polyhexahydrotriazines containing antimicrobial agents
    Patent number: 10316161
    Abstract: Materials and methods are described herein that include forming a porous polymer network with antimicrobial and antifouling properties. The antifouling portion may be a polymer, such as polyethylene glycol, and the antimicrobial portion may be a metal, or a different cationic species, such as a quaternary ammonium salt. The method generally includes forming a reaction mixture comprising a formaldehyde, a bridging group, and moieties with antifouling and antimicrobial properties.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: June 11, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Mareva B. Fevre, Jeannette M. Garcia, James L. Hedrick, Jason T. Wertz, Rudy J. Wojtecki
  • Polyhemiaminal and polyhexahydrotriazine materials from 1,4 conjugate addition reactions
    Patent number: 10316143
    Abstract: Polyhemiaminal (PHA) and polyhexahydrotriazine (PHT) materials are modified by 1,4 conjugate addition chemical reactions to produce a variety of molecular architectures comprising pendant groups and bridging segments. The materials are formed by a method that includes heating a mixture comprising solvent(s), paraformaldehyde, aromatic amine groups, aliphatic amine Michael donors, and Michael acceptors, such as acrylates. The reaction mixtures may be used to prepare polymer pre-impregnated materials and composites containing PHT matrix resin.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: June 11, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Mareva Fevre, Jeannette M. Garcia, James L. Hedrick, Rudy J. Wojtecki
  • BLOCK COPOLYMERS AND SELF-ASSEMBLING NANOPARTICLES FORMED THEREFROM
    Publication number: 20190167584
    Abstract: The subject matter of this invention relates to block copolymers (BCPs) and, more particularly, to block copolymers capable of self-assembly into nanoparticles for the delivery of hydrophobic cargos. The BCPs include a hydrophobic block that contains a thioether functional group that is susceptible to oxidation, transforming the solubility of the block from hydrophobic to hydrophilic, thereby releasing the hydrophobic cargo of the nanoparticle.
    Type: Application
    Filed: December 5, 2017
    Publication date: June 6, 2019
    Inventors: Dylan Boday, Willy Chin, Mareva B. Fevre, Jeannette Garcia, James L. Hedrick, Eunice Leong, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang
  • Porous/nanoporous PHT
    Patent number: 10308765
    Abstract: Methods of forming nanoporous materials are described herein that include forming a polymer network with a chemically removable portion. The chemically removable portion may be polycarbonate polymer that is removable on application of heat or exposure to a base, or a polyhexahydrotriazine (PHT) or polyhemiaminal (PHA) polymer that is removable on exposure to an acid. The method generally includes forming a reaction mixture comprising a formaldehyde, a solvent, a primary aromatic diamine, and a diamine having a primary amino group and a secondary amino group, the secondary amino group having a base-reactive substituent, and heating the reaction mixture to a temperature of between about 50 deg C. and about 150 deg C. to form a polymer. Removing any portion of the polymer results in formation of nanoscopic pores as polymer chains are decomposed, leaving pores in the polymer matrix.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: June 4, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Rudy J. Wojtecki
  • ANTIMICROBIAL STAR POLYMERS WITH LIGHT-ACTIVATED ENHANCED ANTIMICROBIAL ACTIVITY
    Publication number: 20190161562
    Abstract: Techniques regarding a star polymer with light-activated enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a plurality of non-degradable copolymer arms comprising respective first ends and respective second ends. The respective first ends can be crosslinked to form a vinyl polymer core and the respective second ends can have antimicrobial functionality. Further, the polymer can comprise a singlet oxygen generator loaded within the vinyl polymer core. The singlet oxygen generator can generate a singlet oxygen species in response to light.
    Type: Application
    Filed: November 28, 2017
    Publication date: May 30, 2019
    Inventors: Mohd Bakri Bakar, James L. Hedrick, Victoria A. Piunova, Andy Theodora Tek
  • STAR POLYMERS WITH ENHANCED ANTIMICROBIAL ACTIVITY IN RESPONSE TO LIGHT
    Publication number: 20190159456
    Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
    Type: Application
    Filed: November 28, 2017
    Publication date: May 30, 2019
    Inventors: Willy Chin, James L. Hedrick, Noah Frederick Fine Nathel, Victoria A. Piunova, Zhi Xiang Voo, Yi Yan Yang
  • METHOD FOR THE FABRICATION OF THREE-DIMENSIONAL OBJECTS AND APPARATUS FOR SAME
    Publication number: 20190160733
    Abstract: Methods and apparatus comprising a dewetting phase and a polymerization liquid that are immiscible, and can be used for the formation of three-dimensional objects, wherein the method does not require a dead zone. Additionally, methods and apparatus that employ an optically transparent cooling apparatus to mitigate heat generated during the fabrication process, and the use of a mobile phase to provide a shearing interface to reduce interfacial adhesive forces.
    Type: Application
    Filed: May 31, 2017
    Publication date: May 30, 2019
    Inventors: Chad A. Mirkin, David A. Walker, James L. Hedrick, III
  • Photoresponsive hexahydrotriazine polymers
    Patent number: 10301429
    Abstract: This disclosure describes new compositions and methods related to photoresponsive poly(hexahydrotriazines) and related polymers.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: May 28, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Jason T. Wertz, Rudy J. Wojtecki
  • FUNCTIONALIZED BILE ACIDS FOR THERAPEUTIC AND MATERIAL APPLICATIONS
    Publication number: 20190153019
    Abstract: The subject disclosure is directed to functionalized bile acids, preparation thereof, and usage thereof for therapeutic and material applications. In one embodiment, a method of generating functionalized bile acid materials can comprise directly activating a carboxylic acid of a bile acid compound using a coupling agent comprising an amide or ester compound, thereby generating an intermediate bile acid derivative material. The method can further comprise attaching a functional group material to the intermediate bile acid derivative material by reacting the functional group material and the intermediate bile acid derivative material, thereby generating a functionalized bile acid material.
    Type: Application
    Filed: November 17, 2017
    Publication date: May 23, 2019
    Inventors: James L. Hedrick, Nathaniel H. Park
  • Functionalized bile acids for therapeutic and material applications
    Patent number: 10294265
    Abstract: The subject disclosure is directed to functionalized bile acids, preparation thereof, and usage thereof for therapeutic and material applications. In one embodiment, a method of generating functionalized bile acid materials can comprise directly activating a carboxylic acid of a bile acid compound using a coupling agent comprising an amide or ester compound, thereby generating an intermediate bile acid derivative material. The method can further comprise attaching a functional group material to the intermediate bile acid derivative material by reacting the functional group material and the intermediate bile acid derivative material, thereby generating a functionalized bile acid material.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: May 21, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James L. Hedrick, Nathaniel H. Park
  • SILICA-BASED ORGANOGELS VIA HEXAHYDROTRIAZINE-BASED REACTIONS
    Publication number: 20190136007
    Abstract: Silica-based organogels, including aerogels, incorporating hexahydrotriazine and/or hemiaminal species are described. These organo-silica gel materials can have applications as insulating materials. In a particular example, an aerogel includes silica groups and a hexahydrotriazine moiety with at least one nitrogen atom that is covalently linked to a silica group. Methods of making such silica-based organogels are also described.
    Type: Application
    Filed: January 3, 2019
    Publication date: May 9, 2019
    Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Jason T. WERTZ, Rudy J. WOJTECKI
  • POROUS/NANOPOROUS PHT
    Publication number: 20190135979
    Abstract: Methods of forming nanoporous materials are described herein that include forming a polymer network with a chemically removable portion. The chemically removable portion may be polycarbonate polymer that is removable on application of heat or exposure to a base, or a polyhexahydrotriazine (PHT) or polyhemiaminal (PHA) polymer that is removable on exposure to an acid. The method generally includes forming a reaction mixture comprising a formaldehyde, a solvent, a primary aromatic diamine, and a diamine having a primary amino group and a secondary amino group, the secondary amino group having a base-reactive substituent, and heating the reaction mixture to a temperature of between about 50 deg C. and about 150 deg C. to form a polymer. Removing any portion of the polymer results in formation of nanoscopic pores as polymer chains are decomposed, leaving pores in the polymer matrix.
    Type: Application
    Filed: January 8, 2019
    Publication date: May 9, 2019
    Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Rudy J. WOJTECKI
  • SULFUR SCAVENGING MATERIALS
    Publication number: 20190135839
    Abstract: Materials which react with (“scavenge”) sulfur compounds, such as hydrogen sulfide and mercaptans, are useful for limiting sulfur-induced corrosion. Surface-modified particles incorporating a hexahydrotriazine moiety are disclosed and used as sulfur scavengers. These surface-modified particles are used a filter media in fixed filter systems and as additives to fluids including sulfur compounds. The hexahydrotriazine moiety can react with sulfur compounds in such a manner as to bind sulfur atoms to the surface-modified particles, thus allowing removal of the sulfur atoms from fluids such as crude oil, natural gas, hydrocarbon combustion exhaust gases, sulfur polluted air and water. The surface-modified particles may, in general, be sized to allow separation of the particles from the process fluid by sedimentation, size-exclusion filtration or the like.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 9, 2019
    Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Rudy J. WOJTECKI
  • PREPARATION OF ROBUST POLYTHIOAMINAL CARRIERS
    Publication number: 20190077909
    Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 14, 2019
    Inventors: Dylan J. BODAY, Willy CHIN, Jeannette M. GARCIA, James L. HEDRICK, Eunice Leong JIAYU, Shrinivas VENKATARAMAN, Zhi Xiang VOO, Rudy J. WOJTECKI, Yi Yan YANG
  • Degradable polyurethanes containing thioaminal groups
    Patent number: 10227444
    Abstract: Embodiments of the disclosure generally provide compositions and methods related to oligomeric and polymeric urethane materials that contain hydrolyzable polythioaminal groups for use in biomedical applications.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: March 12, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Rudy J. Wojtecki