Patents by Inventor James L. Hedrick

James L. Hedrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymeric coatings and coating method
    Patent number: 10668502
    Abstract: Polymeric coatings and methods of forming polymeric coatings are described. In a method of forming a polymeric coating a first layer is deposited on a substrate. The first layer includes at least one highly soluble diamine component. A second layer is formed on the substrate to contact the first layer. The second layer includes paraformaldehyde and an aromatic diamine including two primary amine groups. Once formed, the first and second layers are heated. Heating causes the components of the first and second layers to cure. For example, the paraformaldehyde from the second layer diffuses into the first layer and reacts via hemiaminal-type chemistry with the high soluble diamine component. The coatings may be substantially homogenous or comprise a compositional gradient in thickness or along the substrate plane depending on deposition methods and other processing parameters.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: June 2, 2020
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Mareva B. Fevre, Jeannette M. Garcia, James L. Hedrick, Rudy J. Wojtecki
  • Antimicrobial ionene compositions with a variety of functional groups
    Patent number: 10667514
    Abstract: Techniques regarding amine monomers that can form ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments described herein can comprise a monomer, which can comprise a molecular backbone. The molecular backbone can comprise a norspermidine structure. The norspermidine structure can comprise a tertiary amino group. Also, the tertiary amino group can comprise a functional group, and an amino group of the norspermidine structure can be capable of being ionized.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: June 2, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • ENHANCED ADHESIVE MATERIALS AND PROCESSES FOR 3D APPLICATIONS
    Publication number: 20200165494
    Abstract: The present invention relates to CNT filled polymer composite system possessing a high thermal conductivity and high temperature stability so that it is a highly thermally conductive for use in 3D and 4D integration for joining device sub-laminate layers. The CNT/polymer composite also has a CTE close to that of Si, enabling a reduced wafer structural warping during high temperature processing cycling. The composition is tailored to be suitable for coating, curing and patterning by means conventionally known in the art.
    Type: Application
    Filed: January 23, 2020
    Publication date: May 28, 2020
    Inventors: James L. Hedrick, Robert D. Miller, Deborah A. Neumayer, Sampath Purushothaman, Mary E. Rothwell, Willi Volksen, Roy R. Yu
  • BIODEGRADABLE FUNCTIONAL POLYCARBONATE NANOPARTICLE CARRIES FOR DELIVERING MOLECULAR CARGO
    Publication number: 20200164088
    Abstract: Techniques regarding the transportation of molecular cargo across the BBB are provided. For example, one or more embodiments described herein can comprise a chemical compound to facilitate molecular encapsulation of the molecular cargo. The chemical compound can comprise a diblock copolymer having a molecular backbone comprising a polycarbonate structure and a polyethylene glycol structure. Also, the polycarbonate structure can be functionalized with boronic acid.
    Type: Application
    Filed: November 28, 2018
    Publication date: May 28, 2020
    Inventors: James L. Hedrick, Nathaniel H. Park, Yi Yan Yang, Zhi Xiang Voo, Jeremy Tan
  • TECHNIQUES FOR ENHANCING THE SELECTIVITY AND EFFICACY OF ANTIMICROBIAL AND ANTICANCER POLYMER AGENTS
    Publication number: 20200164080
    Abstract: The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.
    Type: Application
    Filed: November 27, 2018
    Publication date: May 28, 2020
    Inventors: James L. Hedrick, Nathaniel H. Park, Yi Yan Yang, Zhi Xiang Voo
  • BIODEGRADABLE HYDROGEL AND METHODS FOR USE THEREOF
    Publication number: 20200155686
    Abstract: The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 21, 2020
    Inventors: Mareva B. Fevre, James L. Hedrick, Ashlynn Lee, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang, Zhi Xiang Voo
  • Diagnostic apparatus
    Patent number: 10653349
    Abstract: A diagnostic patch apparatus has a sampling module that includes sampling means for sampling fluid from a patient's skin when the sampling module is placed against the patient's skin, and a sample chamber coupled in fluid communication with the sampling means. The apparatus also has an analysis module that includes a fluid conduit coupled in fluid communication with the sample chamber of the sampling module and a plurality of sensors coupled in fluid communication with the fluid conduit. The apparatus also may have a reader module that includes at least one optical sensor coupled in optical communication with the analysis module, a microcontroller coupled in electrical communication with the at least one sensor of the analysis module, and a wireless communication package coupled in electrical communication with the microcontroller.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: May 19, 2020
    Assignee: International Business Machines Corporation
    Inventors: Emmanuel Delamarche, James L. Hedrick, Minhua Lu, Vince S. Siu
  • Polymers with antimicrobial functionalities
    Patent number: 10653142
    Abstract: Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: May 19, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • STAR POLYMERS WITH ENHANCED ANTIMICROBIAL ACTIVITY IN RESPONSE TO LIGHT
    Publication number: 20200146296
    Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
    Type: Application
    Filed: January 9, 2020
    Publication date: May 14, 2020
    Inventors: Victoria A. Piunova, Noah Frederick Fine Nathel, James L. Hedrick, Yi Yan Yang, Willy Chin, Zhi Xiang Voo
  • Method to generate microcapsules with hexahydrotriazine (HT)-containing shells
    Patent number: 10624860
    Abstract: Materials and methods for preparing a payload-containing microcapsule with walls that have hexahydrotriazine (HT) and/or hemiaminal (HA) structures are disclosed. To an HT small molecule or a HA small molecule, or a combination thereof, in a solvent is added a cross-linking agent, NH4Cl, and a copolymer. The solution is acidified, and a payload agent is added. The HT small molecule and HA small molecule may have orthogonal functionality.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: April 21, 2020
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Brandon M. Kobilka, Jason T. Wertz, Rudy J. Wojtecki
  • Functionalized bile acids for therapeutic and material applications
    Patent number: 10611792
    Abstract: The subject disclosure is directed to functionalized bile acids, preparation thereof, and usage thereof for therapeutic and material applications. In one embodiment, a method of generating functionalized bile acid materials can comprise directly activating a carboxylic acid of a bile acid compound using a coupling agent comprising an amide or ester compound, thereby generating an intermediate bile acid derivative material. The method can further comprise attaching a functional group material to the intermediate bile acid derivative material by reacting the functional group material and the intermediate bile acid derivative material, thereby generating a functionalized bile acid material.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: April 7, 2020
    Assignee: International Business Machines Corporation
    Inventors: James L. Hedrick, Nathaniel H. Park
  • Polycarbonates bearing aromatic N-heterocycles for drug delivery
    Patent number: 10610597
    Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: April 7, 2020
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research, Universidad del Pais Vasco/Euskal Herriko Unibersitatea
    Inventors: Julian M. W. Chan, Amanda C. Engler, James L. Hedrick, Haritz Sardon, Jeremy P. K. Tan, Yi Yan Yang
  • UTILIZING POLYMERS AND ANTIBIOTICS TO ENHANCE ANTIMICROBIAL ACTIVITY AND INHIBIT ANTIBIOTIC RESISTANCE
    Publication number: 20200101105
    Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.
    Type: Application
    Filed: September 27, 2018
    Publication date: April 2, 2020
    Inventors: James L. Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
  • Sulfur scavenging materials
    Patent number: 10604539
    Abstract: Materials which react with (“scavenge”) sulfur compounds, such as hydrogen sulfide and mercaptans, are useful for limiting sulfur-induced corrosion. Surface-modified particles incorporating a hexahydrotriazine moiety are disclosed and used as sulfur scavengers. These surface-modified particles are used a filter media in fixed filter systems and as additives to fluids including sulfur compounds. The hexahydrotriazine moiety can react with sulfur compounds in such a manner as to bind sulfur atoms to the surface-modified particles, thus allowing removal of the sulfur atoms from fluids such as crude oil, natural gas, hydrocarbon combustion exhaust gases, sulfur polluted air and water. The surface-modified particles may, in general, be sized to allow separation of the particles from the process fluid by sedimentation, size-exclusion filtration or the like.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: March 31, 2020
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Rudy J. Wojtecki
  • Antimicrobial polymers capable of supramolecular assembly
    Patent number: 10595527
    Abstract: Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 24, 2020
    Assignee: International Business Machines Corporation
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Yi Yan Yang
  • ANTIMICROBIAL GUANIDINIUM AND THIOURONIUM FUNCTIONALIZED POLYMERS
    Publication number: 20200085059
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Application
    Filed: November 16, 2019
    Publication date: March 19, 2020
    Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L.Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
  • BIODEGRADABLE POLYMERS, COMPLEXES THEREOF FOR GENE THERAPEUTICS AND DRUG DELIVERY, AND METHODS RELATED THERETO
    Publication number: 20200079901
    Abstract: A biodegradable cationic polymer is disclosed, comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a subunit derived from a monomeric diol initiator for the ring-opening polymerization; and an optional endcap group. The biodegradable cationic polymers have low cytotoxicity and form complexes with biologically active materials useful in gene therapeutics and drug delivery.
    Type: Application
    Filed: November 19, 2019
    Publication date: March 12, 2020
    Inventors: Kazuki Fukushima, James L. Hedrick, YiYan Yang
  • ANTIMICROBIAL GUANIDINIUM AND THIOURONIUM FUNCTIONALIZED POLYMERS
    Publication number: 20200077660
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Application
    Filed: November 16, 2019
    Publication date: March 12, 2020
    Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
  • Antimicrobial star polymers with light-activated enhanced antimicrobial activity
    Patent number: 10584191
    Abstract: Techniques regarding a star polymer with light-activated enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a plurality of non-degradable copolymer arms comprising respective first ends and respective second ends. The respective first ends can be crosslinked to form a vinyl polymer core and the respective second ends can have antimicrobial functionality. Further, the polymer can comprise a singlet oxygen generator loaded within the vinyl polymer core. The singlet oxygen generator can generate a singlet oxygen species in response to light.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: March 10, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Mohd Bakri Bakar, James L. Hedrick, Victoria A. Piunova, Andy Theodora Tek
  • PREVENTION OF BIOFILM FORMATION
    Publication number: 20200071542
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 5, 2020
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang