Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.

Abstract: A transfer device for transferring a medical fluid from a vial to a medical fluid injection device includes a vial holder where a vial spike positioned within the vial holder is configured to enter a vial containing a medical fluid when the vial is inserted into the vial holder. An expansion chamber having an interior cavity is in fluid communication with the vial spike. A pressurized gas cartridge is positioned with the interior cavity of the expansion chamber, while a puncture tip is configured to puncture the pressurized gas cartridge when actuated by a user. The vial spike is also configured to be in fluid communication with an injection device attached to the transfer device.

Abstract: A drain gun includes a handle and a trigger. The handle includes a channel and a plurality of inlets. The inlets feed the channel. The trigger causes a staged release of a plurality of fluids from a plurality of cartridges to the channel via the inlets when the cartridges are stored in the handle and feeding the inlets.

Abstract: A target is provided for calibrating and determining the spatial resolution, SNR and/or CNR associated with an X-ray computed tomography system having a rotation axis about which a beam of X-rays is rotated relative to the target to produce signals that are processable to generate an image on an imaging plane perpendicular to the rotation axis. The target comprises a radiopaque body and is configured to be locatable in the system with a centre of the body on the rotation axis. A thickness direction of the body parallel to the rotation axis such that the body extends radially from its centre in the imaging plane. The body contains a plurality of non-radiopaque columns extending longitudinally in the thickness direction of the body. The columns are arranged in first sub-groups of identically-shaped columns with the columns of each first sub-group sharing a respective predetermined transverse diameter.

Abstract: An autonomous fabrication method and system are described. A multi-axis robotic arm having at least one end effector is provided, where the at least one end effector comprises an additive manufacturing (AM) toolhead and a component gripping mechanism. The multi-axis robotic arm is directed to fabricate a first portion of an object in a workspace using the AM toolhead, select a prefabricated part using the component gripping mechanism, place the prefabricated part in a predetermined location of the object, and fabricate a second portion of the object in the workspace using the AM toolhead. The object may be one of an unmanned aerial vehicle and an unmanned ground-based vehicle.

Abstract: A transfer device for transferring a medical fluid from a vial to a medical fluid injection device includes a vial holder where a vial spike positioned within the vial holder is configured to enter a vial containing a medical fluid when the vial is inserted into the vial holder. An expansion chamber having an interior cavity is in fluid communication with the vial spike. A pressurized gas cartridge is positioned with the interior cavity of the expansion chamber, while a puncture tip is configured to puncture the pressurized gas cartridge when actuated by a user. The vial spike is also configured to be in fluid communication with an injection device attached to the transfer device.

Abstract: A transfer device for transferring a medical fluid from a vial to a medical fluid injection device includes a vial holder where a vial spike positioned within the vial holder is configured to enter a vial containing a medical fluid when the vial is inserted into the vial holder. An expansion chamber having an interior cavity is in fluid communication with the vial spike. A pressurized gas cartridge is positioned with the interior cavity of the expansion chamber, while a puncture tip is configured to puncture the pressurized gas cartridge when actuated by a user. The vial spike is also configured to be in fluid communication with an injection device attached to the transfer device.

Abstract: A transfer device for transferring a medical fluid from a vial to a medical fluid injection device includes a vial holder where a vial spike positioned within the vial holder is configured to enter a vial containing a medical fluid when the vial is inserted into the vial holder. An expansion chamber having an interior cavity is in fluid communication with the vial spike. A pressurized gas cartridge is positioned with the interior cavity of the expansion chamber, while a puncture tip is configured to puncture the pressurized gas cartridge when actuated by a user. The vial spike is also configured to be in fluid communication with an injection device attached to the transfer device.

Abstract: A medical fluid injection device, a medical fluid transfer device and a method of administering and transferring a medical fluid are disclosed. The device and method may include a compressed gas canister in fluid communication with an expandable elastic bladder positioned within a vial of drug to provide a means to deliver drug through an injection cannula that is movable between a plurality of positions or through a transfer conduit.

Abstract: A transfer device for transferring a medical fluid from a vial to a medical fluid injection device includes a vial holder where a vial spike positioned within the vial holder is configured to enter a vial containing a medical fluid when the vial is inserted into the vial holder. An expansion chamber having an interior cavity is in fluid communication with the vial spike. A pressurized gas cartridge is positioned with the interior cavity of the expansion chamber, while a puncture tip is configured to puncture the pressurized gas cartridge when actuated by a user. The vial spike is also configured to be in fluid communication with an injection device attached to the transfer device.

Abstract: This invention is directed to a method of growing a plant from the Cannabaceae family, the cultivar or composition produced therefrom, wherein the plant is exposed to artificial lighting of different intensities based on spacing, growth phase, and flowering yield.

Abstract: A device and method for inspecting the deposition of hot melt onto an object to be assembled. A comparison is made between sensed images of the object after application of the hot melt and a predetermined standard to determine if the construction integrity of the object made with the hot melt is within the range established by the standard. Composite images from a sensor operating in the infrared band and another sensor reveal physical features of the object, as well as provide registration information about the placement of the hot melt on the assembled object. Composite images also present a way to visually ascertain ongoing or past production operations in order to trace problems with the raw material used for the object, as well as for the construction process of the object with the hot melt.

Abstract: This invention is directed to a method of growing a plant from the Cannabaceae family, the cultivar or composition produced therefrom, wherein the plant is exposed to artificial lighting of different intensities based on spacing, growth phase, and flowering yield.

Abstract: An electrochemical cell is presented. The cell includes a housing having an interior surface defining a volume, and an elongated, ion-conducting separator disposed in the volume. The separator usually extends in a vertical direction relative to a base of the housing, so as to define a height dimension of the cell. The separator has a first circumferential surface defining a portion of a first compartment. The cell further includes a shim structure disposed generally parallel to the first circumferential surface of the separator between the interior surface and the first circumferential surface of the separator. The structure includes at least two shims, a first shim and a second shim, that substantially overlap each other. An energy storage device including such an electrochemical cell is also provided.

Abstract: The present disclosure provides methods for cannabis cultivation using a capillary mat where the capillary mat is capable of simultaneously irrigating cannabis plants and delivering a selected set of nutrients under controlled and reproducible conditions to provide plasticity to express substantially the same cannabinoid components within the cannabis plants.

Abstract: The invention described herein relates to a cannabis cultivar that produces high concentrations of cannabidiol. The invention further relates to preparations and products derived from the cannabis cultivar. Also provided are methods of treating conditions that are treatable by cannabidiol. by administering a preparation or product derived from the cannabis cultivar.

Abstract: An electrochemical cell includes an outer casing defining at least a portion of an anode electrode chamber, an ionically conducting separator disposed within the outer casing, an inner surface of the separator defining a cathode electrode chamber, a cathode electrode disposed within the cathode chamber, a conductive current collecting body coupled with the cathode electrode, an alkali metal-containing electrolyte disposed in the cathode electrode chamber, and a sealing body coupled with the outer casing and sealing the anode electrode chamber from an external atmosphere disposed outside of the outer casing. The electrolyte supplies alkali metal through the separator to the anode electrode chamber in response to an electric charge applied to the conductive current collecting body. A first content of a gas component in the anode electrode chamber is in the anode electrode chamber in an amount that is less than an amount of a second content of the gas component in ambient air.

Abstract: A device and method for inspecting the deposition of hot melt onto an object to be assembled. A comparison is made between sensed images of the object after application of the hot melt and a predetermined standard to determine if the construction integrity of the object made with the hot melt is within the range established by the standard. Composite images from a sensor operating in the infrared band and another sensor reveal physical features of the object, as well as provide registration information about the placement of the hot melt on the assembled object. Composite images also present a way to visually ascertain ongoing or past production operations in order to trace problems with the raw material used for the object, as well as for the construction process of the object with the hot melt.

Abstract: Fin-based current collectors provide high performance and cost savings in electrochemical cells. Embodiments of the invention provide a current collector for a sodium-metal halide electrochemical cell having at least one substantially flat and elongated metal fin being electrically conductive and having at least one bend with respect to a dominant longitudinal axis of the current collector. The at least one substantially flat and elongated metal fin is configured to be joined to a metal ring of the electrochemical cell via one of welding or brazing.

Abstract: A well pad drainage system is provide, which allows for the testing of drainage water collected from the surface of the well pad prior to the release or removal of the drainage water. The drainage system utilizes a French drain in association with one or more catch basins, a drainpipe for release of uncontaminated drainage water and an extraction line for removal of contaminated drainage water.