Abstract: The present invention relates to variant polypeptides, methods of preparing the variant polypeptides, processes for characterizing the variant polypeptides, compositions and cells comprising the variant polypeptides, and methods of using the variant polypeptides. The invention further relates to complexes comprising the variant polypeptides, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.

Abstract: A wearable sound device includes a venting device including a film structure and an actuator and a driving circuit configured to be controlled by a controller and to drive the actuator, such that the film structure is controlled to form a vent or to seal the vent. The controller is coupled to a sensing device configured to generate a sensing result and determine whether to seal the vent according to the sensing result. The film structure partitions a space within the wearable sound device into a first volume and a second volume. The first volume is connected to or to be connected to an ear canal of a wearable sound device user. The second volume is connected to or to be connected to an ambient of the wearable sound device. The first volume and the second volume are connected via the vent when the vent is formed.

Abstract: An example printhead includes a circulation channel having an inlet for receiving a fluid and an outlet for expelling the fluid, a first nozzle fluidically coupled to the circulation channel, the first nozzle being operable at a first absolute pressure, and a second nozzle fluidically coupled to the circulation channel, the second nozzle being operable at a second absolute pressure, the absolute second pressure being lower than the first absolute pressure. The absolute pressure in the circulation channel decreases as the fluid flows from the inlet to the outlet, and the first nozzle is positioned closer to the inlet of the circulation channel than the second nozzle.

Abstract: Provided is an improved method, system, and computer program product to implement simulation for photonic devices. A composite, multi-domain simulation model is disclosed, with connected domain-specific representations that allow the use of the most relevant simulator technology for a given domain. The model has external connection points either expressed as actual ports or virtual ones, embodied by simulator API calls in the model.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing neural architecture search for machine learning models. In one aspect, a method comprises receiving training data for a machine learning, generating a plurality of candidate neural networks for performing the machine learning task, wherein each candidate neural network comprises a plurality of instances of a layer block composed of a plurality of layers, for each candidate neural network, selecting a respective type for each of the plurality of layers from a set of layer types that comprises, training the candidate neural network and evaluating performance scores for the trained candidate neural networks as applied to the machine learning task, and determining a final neural network for performing the machine learning task based at least on the performance scores for the candidate neural networks.

Abstract: The present invention relates to variant polypeptides, methods of preparing the variant polypeptides, processes for characterizing the variant polypeptides, compositions and cells comprising the variant polypeptides, and methods of using the variant polypeptides. The invention further relates to complexes comprising the variant polypeptides, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.

Abstract: Various approaches for exposing a virtual Non-Uniform Memory Access (NUMA) locality table to the guest OS of a VM running on NUMA system are provided. These approaches provide different tradeoffs between the accuracy of the virtual NUMA locality table and the ability of the system's hypervisor to migrate virtual NUMA nodes, with the general goal of enabling the guest OS to make more informed task placement/memory allocation decisions.

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

Abstract: A device for coupling a propulsor to a marine vessel. The device includes a mounting bracket configured for attachment to the marine vessel. A support frame has a carriage and is configured for the propulsor to be coupled thereto, where the carriage is configured to slidably engage with the mounting bracket into a fixed position. A member is manually engageable to prevent the carriage from sliding out of the fixed position. The propulsor is coupled to the marine vessel by sliding the carriage into the fixed position and engaging the member, where the propulsor is operable to propel the marine vessel in water when the carriage is in the fixed position, and where the propulsor is configured for decoupling from the marine vessel by disengaging the member and sliding the carriage out of engagement with the mounting bracket.

Abstract: The present disclosure provides for a compound according to formula (I) or a pharmaceutically acceptable salt thereof as CaV1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.

Abstract: Compositions comprising and methods for the treatment of cancer using a NeoTCR based cell therapy with a modified TGF?RII expression.

Abstract: A semiconductor device structure may include a substrate having a substrate base comprising a first dopant type; a semiconductor layer disposed on a surface of the substrate base, the semiconductor layer comprising a second dopant type and having an upper surface; and a semiconductor plug assembly comprising a semiconductor plug disposed within the semiconductor layer, the semiconductor plug extending from an upper surface of the semiconductor layer and having a depth at least equal to a thickness of the semiconductor layer, the semiconductor plug having a first boundary, the first boundary formed within the semiconductor layer, and having a second boundary, the second boundary formed within the semiconductor layer and disposed opposite the first boundary, wherein the first boundary and second boundary extend perpendicularly to the surface of the substrate base.

Abstract: A method and system for predicting at least one pharmacokinetic parameter of an agent administered to a subject. One or more processors train, by one or more processors, a neural network based on a simulated training data collection. The simulated training data collection comprising a simulated time-series concentration dataset and a simulated value for a pharmacokinetic parameter that corresponds to the simulated time-series concentration dataset. The one or more processors receive a time-series concentration dataset of the agent obtained from a subject. The one or more processors predict a value for the pharmacokinetic parameter using the time-series concentration dataset and the neural network that has been trained.

Abstract: A method and system for predicting a set of linking parameters that relate pharmacokinetic and pharmacodynamic effects. One or more processors receive a population dataset that comprises a population pharmacokinetic (PK) dataset and a population pharmacodynamic (PD) dataset. The one or more processors transform the population dataset into a plurality of data density images that includes a PK data density image and a PD data density image. The one or more processors predict the set of linking parameters using the plurality of data density images.

Abstract: A method for predicting pharmacokinetic-pharmacodynamic effects over time is provided. A pharmacokinetic pathway of a neural network system that lies at least partially within an ordinary differential equations (ODE) module of the neural network system is trained to generate a dose effect output associated with a drug. A pharmacodynamic pathway of the neural network system that lies at least partially within the ODE module is trained to generate a drug effect output associated with the drug. The drug effect output associated with an administration of the drug over a time period is predicted using the neural network system.

Abstract: A method for predicting a clinical outcome for a subject. Input data for a group of features is formed using baseline data and tumor kinetic data derived from longitudinal data for a set of variables for the subject, the set of variables including tumor size. A clinical outcome output that provides an indication of the clinical outcome for the subject is generated using a pan-indication model and the input data. The pan-indication model includes a gradient boosting decision tree-based ensemble machine learning algorithm.

Abstract: Described herein are techniques for adding adaptive annotations to an electronic content item. For example, a user may insert an annotation by hand drawing the annotation over the content of the content item, in white space around the content, or within an annotation window. The user may also anchor, associate, or link annotations to particular portion of the content item, such that when the content is displayed or rendered on a display of an electronic device, the annotation appears in-line with the content and adjacent to the associated portion.

Abstract: A semiconductor device structure may include a substrate having a substrate base comprising a first dopant type; a semiconductor layer disposed on a surface of the substrate base, the semiconductor layer comprising a second dopant type and having an upper surface; and a semiconductor plug assembly comprising a semiconductor plug disposed within the semiconductor layer, the semiconductor plug extending from an upper surface of the semiconductor layer and having a depth at least equal to a thickness of the semiconductor layer, the semiconductor plug having a first boundary, the first boundary formed within the semiconductor layer, and having a second boundary, the second boundary formed within the semiconductor layer and disposed opposite the first boundary, wherein the first boundary and second boundary extend perpendicularly to the surface of the substrate base.

Abstract: A semiconductor device structure may include a substrate having a substrate base comprising a first dopant type; a semiconductor layer disposed on a surface of the substrate base, the semiconductor layer comprising a second dopant type and having an upper surface; and a semiconductor plug assembly comprising a semiconductor plug disposed within the semiconductor layer, the semiconductor plug extending from an upper surface of the semiconductor layer and having a depth at least equal to a thickness of the semiconductor layer, the semiconductor plug having a first boundary, the first boundary formed within the semiconductor layer, and having a second boundary, the second boundary formed within the semiconductor layer and disposed opposite the first boundary, wherein the first boundary and second boundary extend perpendicularly to the surface of the substrate base.

Abstract: A collaborative system and method for performing wellsite tasks for performing oilfield operations is provided. The system includes a universal bank to store wellsite materials and wellsite instructions, a tag to identify the new wellsite materials, a mobile unit carried by an operator at the wellsite, and a universal bank. The mobile unit is connectable to the universal bank via a wellsite communication link, and includes a wellsite input and a wellsite receiver. The universal bank is connectable to universal resources via a universal communication link, and includes a universal receiver to receive the new wellsite materials from the universal bank. The universal bank includes a universal input to upload universal materials and validated wellsite instructions to the universal bank based on the input wellsite materials whereby wellsite materials and wellsite instructions are selectively accessible by the operator.