Abstract: A method and system for evaluating a treatment using one or more model parameters associated with a quantitative systems pharmacology (QSP) system. Input data corresponding to a treatment is received. The input data is sent to a machine learning system that has been trained, the machine learning system representing at least a portion of the QSP model. The machine learning system is used to generate a set of values for a set of treatment effect parameters associated with the QSP model. A final output is generated based on an evaluation of the treatment on a subject using the set of values for the set of treatment effect parameters.

Abstract: A semiconductor device structure may include a substrate having a substrate base comprising a first dopant type; a semiconductor layer disposed on a surface of the substrate base, the semiconductor layer comprising a second dopant type and having an upper surface; and a semiconductor plug assembly comprising a semiconductor plug disposed within the semiconductor layer, the semiconductor plug extending from an upper surface of the semiconductor layer and having a depth at least equal to a thickness of the semiconductor layer, the semiconductor plug having a first boundary, the first boundary formed within the semiconductor layer, and having a second boundary, the second boundary formed within the semiconductor layer and disposed opposite the first boundary, wherein the first boundary and second boundary extend perpendicularly to the surface of the substrate base.

Abstract: A method and system for predicting at least one pharmacokinetic parameter of an agent administered to a subject. One or more processors train, by one or more processors, a neural network based on a simulated training data collection. The simulated training data collection comprising a simulated time-series concentration dataset and a simulated value for a pharmacokinetic parameter that corresponds to the simulated time-series concentration dataset. The one or more processors receive a time-series concentration dataset of the agent obtained from a subject. The one or more processors predict a value for the pharmacokinetic parameter using the time-series concentration dataset and the neural network that has been trained.

Abstract: A method and system for predicting a set of linking parameters that relate pharmacokinetic and pharmacodynamic effects. One or more processors receive a population dataset that comprises a population pharmacokinetic (PK) dataset and a population pharmacodynamic (PD) dataset. The one or more processors transform the population dataset into a plurality of data density images that includes a PK data density image and a PD data density image. The one or more processors predict the set of linking parameters using the plurality of data density images.

Abstract: A method for predicting pharmacokinetic-pharmacodynamic effects over time is provided. A pharmacokinetic pathway of a neural network system that lies at least partially within an ordinary differential equations (ODE) module of the neural network system is trained to generate a dose effect output associated with a drug. A pharmacodynamic pathway of the neural network system that lies at least partially within the ODE module is trained to generate a drug effect output associated with the drug. The drug effect output associated with an administration of the drug over a time period is predicted using the neural network system.

Abstract: A method for predicting a clinical outcome for a subject. Input data for a group of features is formed using baseline data and tumor kinetic data derived from longitudinal data for a set of variables for the subject, the set of variables including tumor size. A clinical outcome output that provides an indication of the clinical outcome for the subject is generated using a pan-indication model and the input data. The pan-indication model includes a gradient boosting decision tree-based ensemble machine learning algorithm.

Abstract: Described herein are techniques for adding adaptive annotations to an electronic content item. For example, a user may insert an annotation by hand drawing the annotation over the content of the content item, in white space around the content, or within an annotation window. The user may also anchor, associate, or link annotations to particular portion of the content item, such that when the content is displayed or rendered on a display of an electronic device, the annotation appears in-line with the content and adjacent to the associated portion.

Abstract: A semiconductor device structure may include a substrate having a substrate base comprising a first dopant type; a semiconductor layer disposed on a surface of the substrate base, the semiconductor layer comprising a second dopant type and having an upper surface; and a semiconductor plug assembly comprising a semiconductor plug disposed within the semiconductor layer, the semiconductor plug extending from an upper surface of the semiconductor layer and having a depth at least equal to a thickness of the semiconductor layer, the semiconductor plug having a first boundary, the first boundary formed within the semiconductor layer, and having a second boundary, the second boundary formed within the semiconductor layer and disposed opposite the first boundary, wherein the first boundary and second boundary extend perpendicularly to the surface of the substrate base.

Abstract: A semiconductor device structure may include a substrate having a substrate base comprising a first dopant type; a semiconductor layer disposed on a surface of the substrate base, the semiconductor layer comprising a second dopant type and having an upper surface; and a semiconductor plug assembly comprising a semiconductor plug disposed within the semiconductor layer, the semiconductor plug extending from an upper surface of the semiconductor layer and having a depth at least equal to a thickness of the semiconductor layer, the semiconductor plug having a first boundary, the first boundary formed within the semiconductor layer, and having a second boundary, the second boundary formed within the semiconductor layer and disposed opposite the first boundary, wherein the first boundary and second boundary extend perpendicularly to the surface of the substrate base.

Abstract: A collaborative system and method for performing wellsite tasks for performing oilfield operations is provided. The system includes a universal bank to store wellsite materials and wellsite instructions, a tag to identify the new wellsite materials, a mobile unit carried by an operator at the wellsite, and a universal bank. The mobile unit is connectable to the universal bank via a wellsite communication link, and includes a wellsite input and a wellsite receiver. The universal bank is connectable to universal resources via a universal communication link, and includes a universal receiver to receive the new wellsite materials from the universal bank. The universal bank includes a universal input to upload universal materials and validated wellsite instructions to the universal bank based on the input wellsite materials whereby wellsite materials and wellsite instructions are selectively accessible by the operator.

Abstract: Systems, platforms, methods and media for providing genomic services are disclosed. In one example, a genomic services platform comprises a network interface through which are received genomic sequence reads derived from a biological sample obtained from a user The platform also includes a bioinformatics processing pipeline including a read alignment module configured to generate observed sequence data by aligning the sequence reads relative to a reference sequence, a variant calling module operative to identify observed variants in the observed sequence data, and a variant refinement module for producing a set of refined variants associated with the user. A variant imputation module produces a set of imputed variants associated with the user, and a variant storage module disposed to receive a query from network infrastructure of a partner application provider and to provide selected ones of the refined or imputed variants in response to the query.

Abstract: A single-magnet double-tone-circuit coaxial loudspeaker includes a shell, a U iron, a magnet, a spring washer, a first diaphragm assembly, a second diaphragm assembly, an upper cover and a terminal plate. A single “magnet+spring washer+U iron” magnetic circuit is extended to be two upper-lower coaxial magnetic circuits, therefore, the first diaphragm assembly and the second diaphragm assembly which are electrically connected to the terminal plate generate a double-magnetic-circuit feature by sharing a single-magnet system. High frequency and low frequency wave bands are driven independently, such that high frequency and low frequency portions can achieve a better sound resolution effect. The complementation of the two reduces distortion, thus improves the overall acoustic performance of the loudspeaker.

Abstract: Systems and methods are provided for protected search. A search query to be performed using at least one data store is received from a computing device of a user. The user is not authorized to access the at least one data store. One or more search results that are responsive to the search query from the at least one data store are determined. The one or more search results are aggregated based on one or more categories. At least a subset of the aggregated search results is provided to the computing device of the user.

Abstract: A semiconductor device structure may include a substrate having a substrate base comprising a first dopant type; a semiconductor layer disposed on a surface of the substrate base, the semiconductor layer comprising a second dopant type and having an upper surface; and a semiconductor plug assembly comprising a semiconductor plug disposed within the semiconductor layer, the semiconductor plug extending from an upper surface of the semiconductor layer and having a depth at least equal to a thickness of the semiconductor layer, the semiconductor plug having a first boundary, the first boundary formed within the semiconductor layer, and having a second boundary, the second boundary formed within the semiconductor layer and disposed opposite the first boundary, wherein the first boundary and second boundary extend perpendicularly to the surface of the substrate base.

Abstract: Systems, platforms, methods and media for providing genomic services axe disclosed. In one example, a system for providing genomic services comprises genomic sequencing equipment configured to generate sequence reads based upon a biological sample obtained from a user, store the sequence reads in a FASTQ storage file, and communicate the FASTQ file electronically to a recipient. The system also includes a genomic services platform which includes a network interface through which the sequence reads are received, and a bioinformatics processing pipeline. The bioinformatics processing pipeline includes a read alignment module configured to generate observed sequence data, and a variant calling module is operative to identify observed variants in the observed sequence data. A variant storage module is disposed to receive a query from network infrastructure of a partner application provider and to provide selected ones of refined variants in response to a query.

Abstract: Systems, platforms, methods and media for providing genomic services are disclosed. In one example, a genomic services platform comprises a network interface through which are received genomic sequence reads derived from a biological sample obtained from a user. The platform also includes a bioinformatics processing pipeline including a read alignment module configured to generate observed sequence data by aligning the sequence reads relative to a reference sequence, a variant calling module operative to identify observed variants in the observed sequence data, and a variant refinement module for producing genotype data including a set of refined variants associated with the user. A variant imputation module produces a set of imputed variants associated with the user, and is configured to receive, as input, at least some of the genotype data and separate the genotype data into high-quality and low-quality genotypes based on a genotype quality.

Abstract: Methods, systems and media for providing genomic services are disclosed. In one example, a system comprises genomic sequencing equipment configured to generate sequence reads based upon a biological sample obtained from a user, and a genomic services platform. The platform includes a network interface through which the sequence reads are received. A bioinformatics processing pipeline includes a read alignment module configured to generate observed sequence data by aligning the sequence reads relative to a reference sequence, and a variant calling module is operative to identify observed variants in the observed sequence data. Genomic data storage contains the observed variants in the observed sequence data. A variant storage module is disposed to receive a query from network infrastructure of a partner application provider and to provide genomic information based on or derived from the observed variants in response to the query.

Abstract: Systems, platforms, methods and media for providing genomic services are disclosed. In one example, a platform comprises a network interface, in communication with a sequencing laboratory, through which are received genomic sequence reads derived from a biological sample obtained from a user, and a bioinformatics processing pipeline. The pipeline includes a read alignment module configured to generate observed sequence data by aligning the sequence reads relative to a reference sequence, a variant calling module operative to identify observed variants in the observed sequence data, a genomic data storage containing at least the observed variants in the observed sequence data, and a variant storage module disposed to receive a query from network infrastructure of a partner application provider and to provide genomic information based on or derived from the observed variants in response to the query.

Abstract: Systems, platforms, methods and media for providing genomic services are disclosed. In one example, a genomic services platform comprises a network interface through which genomic sequence reads derived from a biological sample obtained from a user are received. The platform also includes a bioinformatics processing pipeline that includes a read alignment module configured to receive a genomics file from genomic sequencing equipment and use data contained therein to generate observed sequence data by aligning the sequence reads relative to a reference sequence. A variant calling module identifies observed variants in the observed sequence data and stores the observed variants in a variant calling file. A variant refinement module produces genotype data including a set of refined variants associated with the user, and a variant imputation module produces a set of imputed variants associated with the user.

Abstract: Systems, platforms, methods and media for providing genomic services are disclosed. In one example, a genomic services platform comprises a network interface through which genomic sequence reads derived from a biological sample are received. The platform also includes a bioinformatics processing pipeline that comprises a read alignment module configured to generate observed sequence data by aligning the sequence reads relative to a reference sequence, a variant calling module operative to identify observed variants in the observed sequence data, and a variant refinement module for producing a set of refined variants associated with the biological sample. A variant imputation module produces a set of imputed variants associated with the user and a variant storage module, operating on a server-less framework, is disposed to receive a query from network infrastructure of a partner application provider and to provide selected ones of the refined or imputed variants m response to the query.