Patents by Inventor James M. Chen

James M. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6914026
    Abstract: The present invention is directed to an iron-promoted zeolite beta catalyst useful in the selective catalytic reduction of nitrogen oxides with ammonia in which the iron-promoted zeolite beta is treated so as to provide increased amounts of the iron promoter in the form of Fe(OH). The stabilized zeolite is formed by cation exchange of an iron salt into a zeolite beta which has a reduced sodium content such as by exchanging a sodium beta with ammonium or hydrogen cations. A zeolite beta having a reduced carbon content and a Si/Al ratio of no more than 10 also increases the Fe(OH) content of the iron-promoted catalyst. The iron-promoted catalyst which has the iron in the form of Fe(OH) is characterized by a peak at 3680±5 cm?1 in the IR spectra.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: July 5, 2005
    Assignee: Engelhard Corporation
    Inventors: Pascaline H. Tran, Xinsheng Liu, James M. Chen
  • Patent number: 6825354
    Abstract: Compounds of the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: November 30, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, Derek C. Cole, James M. Chen, Jamie M. Davis, George T. Grosu
  • Publication number: 20040229924
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: June 17, 2004
    Publication date: November 18, 2004
    Applicant: WYETH
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, James M. Chen, Arie Zask, Vincent P. Sandanayaka, Mila T. Du, Jannie L. Baker
  • Patent number: 6812227
    Abstract: Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: November 2, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Publication number: 20040167124
    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Application
    Filed: October 16, 2003
    Publication date: August 26, 2004
    Applicant: GILEAD SCIENCES, INC.
    Inventors: James M. Chen, Xiaowu Chen, Maria Fardis, Haolun Jin, Choung U. Kim, Laura N. Schacherer
  • Publication number: 20040157804
    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Application
    Filed: October 15, 2003
    Publication date: August 12, 2004
    Applicant: GILEAD SCIENCES, INC.
    Inventors: James M. Chen, Xiaowu Chen, Maria Fardis, Haolun Jin, Choung U. Kim, Laura N. Schacherer
  • Patent number: 6762178
    Abstract: Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: July 13, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen
  • Publication number: 20040120873
    Abstract: The present invention is directed to a metal-promoted zeolite beta catalyst useful in the selective catalytic reduction of nitrogen oxides with ammonia in which the zeolite beta is pre-treated so as to provide the zeolite with improved hydrothermal stability.
    Type: Application
    Filed: December 9, 2003
    Publication date: June 24, 2004
    Inventors: Pascaline H. Tran, Xinsheng Liu, James M. Chen, Gerard D. Lapadula, Howard Furbeck
  • Publication number: 20040121316
    Abstract: Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
    Type: Application
    Filed: April 25, 2003
    Publication date: June 24, 2004
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Gabriel Birkus, James M. Chen, Xiaowu Chen, Tomas Cihlar, Eugene J. Eisenberg, Marcos Hatada, Gong-Xin He, Choung U. Kim, William A. Lee, Martin J. McDermott, Sundaramoorthi Swaminathan
  • Patent number: 6753337
    Abstract: Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: June 22, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, James M. Chen, Arie Zask, Vincent P. Sandanayaka, Mila T. Du, Jannie L. Baker
  • Patent number: 6716833
    Abstract: Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: April 6, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Publication number: 20040033988
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: February 27, 2003
    Publication date: February 19, 2004
    Applicant: Wyeth
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Patent number: 6689709
    Abstract: The present invention is directed to a metal-promoted zeolite beta catalyst useful in the selective catalytic reduction of nitrogen oxides with ammonia in which the zeolite beta is pre-treated so as to provide the zeolite with improved hydrothermal stability. The stabilized beta zeolite is provided by incorporating into the zeolite structure non-framework aluminum oxide chains. The aluminum oxide chains can be incorporated into the zeolite structure by a unique steaming regimen or by treatment with rare earth metals, such as cerium. The treatment process is unlike well-known methods of dealuminizing zeolites for the purpose of increasing the silica to alumina ratio. In the present invention, the non-framework aluminum oxide is characterized by FT-IR by a peak at 3781±2 cm−1, which when present, stabilizes the zeolite against further dealumination such as under oxidizing and harsh hydrothermal conditions.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: February 10, 2004
    Assignee: Engelhard Corporation
    Inventors: Pascaline H. Tran, Xinsheng Liu, James M. Chen, Gerard D. Lapadula, Howard Furbeck
  • Publication number: 20030108467
    Abstract: The present invention is directed to a metal-promoted zeolite beta catalyst useful in the selective catalytic reduction of nitrogen oxides with ammonia in which the zeolite beta is pre-treated so as to provide the zeolite with improved hydrothermal stability.
    Type: Application
    Filed: December 26, 2002
    Publication date: June 12, 2003
    Inventors: Pascaline H. Tran, Xinsheng Liu, James M. Chen, Gerard D. Lapadula, Howard Furbeck
  • Publication number: 20030050182
    Abstract: The present invention is directed to an iron-promoted zeolite beta catalyst useful in the selective catalytic reduction of nitrogen oxides with ammonia in which the iron-promoted zeolite beta is treated so as to provide increased amounts of the iron promoter in the form of Fe(OH).
    Type: Application
    Filed: September 7, 2001
    Publication date: March 13, 2003
    Applicant: ENGELHARD CORPORATION
    Inventors: Pascaline H. Tran, Xinsheng Liu, James M. Chen
  • Publication number: 20030008849
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: December 27, 2000
    Publication date: January 9, 2003
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Publication number: 20020188132
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: December 4, 2000
    Publication date: December 12, 2002
    Inventors: Jeremy I. Levin, James M. Chen, Frances C. Nelson
  • Publication number: 20020147342
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: November 13, 2001
    Publication date: October 10, 2002
    Applicant: American Cyanamid Company
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, Derek C. Cole, James M. Chen, Jamie M. Davis, George T. Grosu
  • Publication number: 20020127163
    Abstract: A gas stream containing nitrous oxide and ammonia is contacted with a catalyst composition containing a zeolite. N2O is reduced to N2 and H2O at low temperatures in a highly efficient manner. Ammonia-mediated reduction of nitrous oxide can be effectuated from gas streams having N2O concentrations as low as 1%. The gas stream may also contact a catalytic composition selective for the reduction of NOx. In this way, N2O and Nx treatment may be effectuated in a single process stream.
    Type: Application
    Filed: March 12, 2001
    Publication date: September 12, 2002
    Applicant: ENGELHARD CORPORATION
    Inventors: James M. Chen, Pascaline H. Tran, Michael Durilla, Stanley S. Mack
  • Publication number: 20020103163
    Abstract: The present invention relates to acetylenic aryl sulfonamide thiols which act as inhibitors of TNF-&agr; converting enzyme (TACE). The compounds of the present invention are useful in disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Application
    Filed: August 30, 2001
    Publication date: August 1, 2002
    Applicant: American Cyanamid Company
    Inventors: Jeremy I. Levin, James M. Chen