Patents by Inventor James M. Cook

James M. Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200181146
    Abstract: Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.
    Type: Application
    Filed: March 20, 2017
    Publication date: June 11, 2020
    Inventors: James M. Cook, Guanguan Li, Michael Ming-Jin Poe, Miroslav M. Savic, Etienne Sibille
  • Publication number: 20200143906
    Abstract: The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
    Type: Application
    Filed: January 17, 2020
    Publication date: May 7, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, British Columbia Cancer Agency Branch, Arizona Board of Regents on Behalf of the University of Arizona, Universitat de Barcelona, Hospital Clinic de Barcelona, The Cleveland Clinic Foundation, Board of Regents of the University of Nebraska, Oregon Health & Science University, Julius-Maximilians-University of Würzburg, Oslo University Hospital HF
    Inventors: Louis M. Staudt, George W. Wright, David William Scott, Joseph M. Connors, Randy D. Gascoyne, Lisa Rimsza, Elias Campo Guerri, Raymond Tubbs (Deceased), Timothy C. Greiner, James Robert Cook, Kai Fu, Paul Michael Williams, Chih-Jian Lih, Elaine S. Jaffe, Rita M. Braziel, Andreas Rosenwald, Erlend B. Smeland, Wing C. Chan, German Ott, Jan Delabie, Dennis Weisenburger
  • Publication number: 20200105364
    Abstract: In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements. In embodiments, the invention distinguishes between PMBCL and DLBCL based on gene expression signatures, and can further distinguish between DLBCL subtypes. In embodiments of the invention, the distinctions are used in methods of treatment.
    Type: Application
    Filed: December 13, 2019
    Publication date: April 2, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, British Columbia Cancer Agency Branch, Mayo Foundation for Medical Education and Research, Julius-Maximilians-University of Würzburg, Board of Regents of the University of Nebraska, Oslo University Hospital HF, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut D? Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Robert Bosch Gesellschaft fuer medizinische Forschung mbH, Oregon Health & Science University, City of Hope, The Cleveland Clinic Foundation
    Inventors: Louis M. Staudt, Christian Steidl, Anja Mottok, George W. Wright, David William Scott, Lisa M. Rimsza, Andreas Rosenwald, Randy Gascoyne, Timothy Greiner, Dennis Weisenburger, Erlend B. Smeland, Jan Delabie, Elias Campo Guerri, German Ott, Rita Braziel, Elaine S. Jaffe, Kai Fu, Wing C. Chan, Joo Song, James R. Cook
  • Patent number: 10607717
    Abstract: The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: March 31, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, British Columbia Cancer Agency Branch, Arizona Board of Regents on behalf of the University of Arizona, Universitat de Barcelona, Hospital Clinic de Barcelona, The Cleveland Clinic Foundation, Board of Regents of the University of Nebraska, Oregon Health and Science University, Julius-Maximilians-University of Würzburg, Oslo University Hospital HF
    Inventors: Louis M. Staudt, George W. Wright, David William Scott, Joseph M. Connors, Randy D. Gascoyne, Lisa Rimsza, Elias Campo Guerri, Raymond Tubbs, Timothy C. Greiner, James Robert Cook, Kai Fu, Paul Michael Williams, Chih-Jian Lih, Elaine S. Jaffe, Rita M. Braziel, Andreas Rosenwald, Erlend B. Smeland, Wing C. Chan, German Ott, Jan Delabie, Dennis Weisenburger
  • Publication number: 20200078451
    Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.
    Type: Application
    Filed: May 14, 2019
    Publication date: March 12, 2020
    Inventors: Scott M. KEE, Paul I. COOK, James R. SMITH, Robert KLING, Scott A. FOWLER, David WEBER
  • Publication number: 20200025789
    Abstract: The present application includes a computer-implemented method for detecting a tamper event. The method includes a step of receiving, from one or more sensors on an integrated module, data indicating one or more of light, acceleration, magnetic field, rotation, temperature, pressure, humidity, and audio. The method also includes a step of transmitting, to a microcontroller/evaluation engine coupled to the integrated module, the received data from the one or more sensors. The method further includes a step of determining, via the microcontroller, the received data exceeding one or more configurable thresholds of the tamper event. The method even further includes a step of assigning, via the microcontroller, a score associated with each of the one or more configurable thresholds being exceeded by the received data. The method yet even further includes a step of collecting, via the microcontroller, an aggregate total based on the assigning step.
    Type: Application
    Filed: July 16, 2019
    Publication date: January 23, 2020
    Inventors: James Andrew Cook, Eric David Nystrom, Renato M. Camarda
  • Publication number: 20200025788
    Abstract: The present application describes an integrated module. The integrated module includes a microcontroller, an inertial measurement unit (IMU), a low-power accelerometer, and an environmental sensor. A distance between the environmental sensor and the IMU is greater than a distance between the IMU and the low-power accelerometer. The present application also describes a method of making an integrated module. The present application also describes a tamper detection system.
    Type: Application
    Filed: July 16, 2019
    Publication date: January 23, 2020
    Inventors: Renato M. Camarda, James Andrew Cook, Eric David Nystrom, George Mace Mavroleon
  • Publication number: 20200002937
    Abstract: A loosefill insulation installation includes a loosefill insulation material made from fiberglass fibers. The loosefill insulation material unexpectedly has improved thermal performance, even though the amount of mineral oil applied to the fiberglass fibers is reduced. For example, the fiberglass fibers can be coated with a mineral oil in an amount that is between 0.1% and 0.6% of the weight of the fiberglass fibers, such as about 0.375%.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 2, 2020
    Inventors: Michael Evans, James Justin Evans, Patrick M. Gavin, Steven Schmitt, Tim Newell, William E. Downey, Kenneth J. Wiechert, Justin Depenhart, David Michael Cook
  • Patent number: 10458128
    Abstract: A machine for distributing insulation material from a package of compressed insulation material has a chute having an inlet end and an outlet end, the inlet end configured to receive compressed insulation material. A lower unit has a shredding chamber configured to receive the insulation material from the outlet end of the chute. The shredding chamber includes shredders and at least one agitator configured to condition the insulation material, thereby forming conditioned insulation material. A discharge mechanism receives the conditioned insulation material exiting the shredding chamber and distributes the conditioned insulation material into a distribution airstream. A blower is configured to provide the distribution airstream flowing through the discharge mechanism, the blower driven by a blower motor.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: October 29, 2019
    Assignee: Owens Corning Intellecutal Capital, LLC
    Inventors: David M. Cook, Brandon Robinson, Christopher M. Relyea, James W. Rinne, Brent J. Carey
  • Patent number: 10450742
    Abstract: A loosefill insulation installation includes a loosefill insulation material made from fiberglass fibers. The loosefill insulation material unexpectedly has improved thermal performance, even through the amount of mineral oil applied to the fiberglass fibers is reduce. For example, the fiberglass fibers can be coated with a mineral oil in an amount that is between 0.1% and 0.6% of the weight of the fiberglass fibers, such as about 0.375%.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: October 22, 2019
    Assignee: Owens Corning Intellectual Capital, LLC
    Inventors: Michael Evans, James Justin Evans, Patrick M. Gavin, Steven Schmitt, Tim Newell, William E. Downey, Kenneth J. Wiechert, Justin Depenhart, David Michael Cook
  • Publication number: 20190300534
    Abstract: Described herein are ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.
    Type: Application
    Filed: February 25, 2019
    Publication date: October 3, 2019
    Inventors: James M. Cook, Michael Ming-Jin Poe, Kashi Reddy Methuku, Guanguan Li
  • Patent number: 10335467
    Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: July 2, 2019
    Assignee: CSL Behring L.L.C.
    Inventors: Scott M. Kee, Paul I. Cook, James R. Smith, Robert Kling, Scott A. Fowler, David Weber
  • Patent number: 10327386
    Abstract: A header which is couplable with a base unit of an agricultural harvester. The header includes a rotatably driven first sub-system, a rotatably driven second sub-system, a first input drive, and a second input drive. The first input drive is mechanically couplable with the base unit. The first input drive is configured for driving the first sub-system at a first operating speed. The second input drive is mechanically couplable with the base unit. The second input drive is configured for driving the second sub-system at a second operating speed which is independent of the first operating speed.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: June 25, 2019
    Assignee: CNH Industrial America LLC
    Inventors: James M. Gessel, Jaclyn Raetzman, Joel T. Cook, Nicholas J. Laufenberg, Jay D. Schroeder
  • Publication number: 20190153539
    Abstract: The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
    Type: Application
    Filed: April 20, 2017
    Publication date: May 23, 2019
    Applicants: The United States of America, as represented by the secretary, Dep. of Health and Human Service, British Columbia Cancer Agency Branch, Julius-Maximilians - University of Würzburg, Oregon Health and Science University, Hospital Clinic de Barcelona, Universitat de Barcelona, Oslo University Hospital HF, Board of Regents of the University of Nebraska, The Cleveland Clinic Foundation, Mayo Foundation for Medical Education and Research
    Inventors: Louis M. Staudt, David William Scott, George W. Wright, Andreas Rosenwald, Pau Abrisqueta, Rita Braziel, Elias Campo Guerri, Wing C. Chan, Joseph M. Connors, Jan Delabie, Diego Villa, Kai Fu, Randy D. Gascoyne, Timothy Greiner, Elaine S. Jaffe, Pedro Jares, Anja Mottok, German Ott, Lisa M. Rimsza, Graham Slack, Dennis Weisenburger, Erlend B. Smeland, James Robert Cook
  • Publication number: 20190134910
    Abstract: Novel tools and techniques for entertainment device communication to printing devices are provided. A system includes a printing device and media player coupled to the printing device. The media device may include a processor, and a non-transitory computer readable medium comprising instructions executable by the processor to obtain a content stream including at least one of an audio stream or a video stream, the content stream further including a data stream including a trigger associated with a printable model. The instructions may further be executable to obtain a 3-D model file associated with the printable model responsive to an occurrence of the trigger, transmit at least one of the 3-D model file or printing instructions based on the 3-D model file to the printing device, and print, via the printing device, the printable model based on the 3-D model file.
    Type: Application
    Filed: June 4, 2018
    Publication date: May 9, 2019
    Inventors: Steven M. Casey, James M. Feger, Robert J. Morrill, Charles I. Cook
  • Patent number: 10168812
    Abstract: This application describes, in part, system and methods for reducing unintentional performance of actions, such as orders, on a computing device. In some implementations, ordering may be controlled by identifying an input within an action region and determining that the input is an intentional input before completing an order. For example, to be considered an intentional input, the input may need to remain in an action region for a predetermined time duration, or may need to move across a majority of the action region.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: January 1, 2019
    Assignee: Amazon Technologies, Inc.
    Inventors: Andrew Joseph Yates, Te-Lin Tuan, James M. Cook
  • Patent number: 10095609
    Abstract: A test device may include an application that accesses online content. In some examples, a test intermediary and/or a test user interface (UI) are downloaded to the test device in response to a request by the application for obtaining the content from a network location. The test intermediary may be positioned to receive communications between the application and the content during testing of the content and/or the application. For example, the test intermediary may intercept metrics and other callbacks passed between the content and the application during manual or automated testing. In some instances, the test intermediary may provide the metrics and/or other test outputs for display in the test user UI rendered on the test device. The content may be rendered to be functional within the test UI, and the existence of the test intermediary and/or the test UI may be transparent to the application and the content.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: October 9, 2018
    Assignee: Amazon Technologies, Inc.
    Inventors: James M. Cook, Daniel Thomas Tattersall, Te-Lin Tuan
  • Patent number: 9879020
    Abstract: Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target alpha-4 and alpha-5 GABAA receptors and methods of using those compounds to treat bronchoconstriction and inflammation are provided herein.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: January 30, 2018
    Assignees: UWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
    Inventors: Douglas C. Stafford, James M. Cook, Alexander E. Arnold, Charles W. Emala, George Gallos, Michael Rajesh Stephen
  • Patent number: 9733739
    Abstract: This application describes, in part, system and methods for reducing unintentional performance of actions, such as orders, on a computing device. In some implementations, ordering may be controlled by identifying an input within an action region and determining that the input is an intentional input before completing an order. For example, to be considered an intentional input, the input may need to remain in an action region for a predetermined time duration, or may need to move across a majority of the action region.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: August 15, 2017
    Assignee: Amazon Technologies, Inc.
    Inventors: Andrew Joseph Yates, Te-Lin Tuan, James M. Cook
  • Patent number: RE47475
    Abstract: In preferred embodiments, the present invention provides methods of treatment and pharmaceutical compositions for the suppression, alleviation and prevention of the often chronic, severe and debilitating pain that can accompany inflammatory diseases and neuropathic insults, pain that is often unresponsive to conventional analgesic treatment. The preferred embodiments of the present invention further relate to methods of treatment and pharmaceutical compositions using benzodiazepine derivatives that provide suppression, alleviation and prevention of neuropathic pain, migraine-related pain and inflammatory pain with reduced sedative and ataxic side effects.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: July 2, 2019
    Assignee: WISYS TECHNOLOGY FOUNDATION, INC.
    Inventors: James M. Cook, Shengming Huang, Rahul Edwankar, Ojas A. Namjoshi, Zhi-Jian Wang, Qi Huang, Xiaohui He, Xiaoyan Li, Jianming Yu, Dongmei Han