Abstract: The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

Abstract: Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target alpha-4 and alpha-5 GABAA receptors and methods of using those compounds to treat bronchoconstriction and inflammation are provided herein.

Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimmers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimmers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimmers, analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.

Abstract: Described herein are ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimers, and analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.

Abstract: A test device may include an application that accesses online content. In some examples, a test intermediary and/or a test user interface (UI) are downloaded to the test device in response to a request by the application for obtaining the content from a network location. The test intermediary may be positioned to receive communications between the application and the content during testing of the content and/or the application. For example, the test intermediary may intercept metrics and other callbacks passed between the content and the application during manual or automated testing. In some instances, the test intermediary may provide the metrics and/or other test outputs for display in the test user UI rendered on the test device. The content may be rendered to be functional within the test UI, and the existence of the test intermediary and/or the test UI may be transparent to the application and the content.

Abstract: A test device may include an application that accesses online content. In some examples, a test intermediary and/or a test user interface (UI) are downloaded to the test device in response to a request by the application for obtaining the content from a network location. The test intermediary may be positioned to receive communications between the application and the content during testing of the content and/or the application. For example, the test intermediary may intercept metrics and other callbacks passed between the content and the application during manual or automated testing. In some instances, the test intermediary may provide the metrics and/or other test outputs for display in the test user UI rendered on the test device. The content may be rendered to be functional within the test UI, and the existence of the test intermediary and/or the test UI may be transparent to the application and the content.

Abstract: Methods and apparatus for firing a projectile in response to a threat according to various aspects of the present invention operate in conjunction with a computer coupled to a launch system for the projectile. The computer may be configured to select the projectile from multiple available projectiles and calculate a fire control solution according to a characteristic of the selected projectile. Calculating the fire control solution may comprise deriving the fire control solution from a look-up table according to a predicted intercept point. The computer may initiate a launch of the selected projectile and provide the fire control solution to the selected projectile.

Abstract: The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

Abstract: The present invention provides compounds and methods of using of the compounds as anti-infective and anthelminitc agents. In a preferred embodiment, the present invention provides the following compound of Formula III: wherein: R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is OH or CH(2n+1)O, wherein n is 1-10; R2 is OH or CH(2n+1)O, where n is 1-10; W is alkyl, phenyl, halophenyl, pyridyl, piperidyl, or a substituted or unsubstituted aryl group, including unsubstituted and substituted aromatic heterocycles; and L is an optional linker or linking group selected from O, S, NH, CF2, or CH2, and x=0 or 1, i.e., if x=0, no linking group is present and when x=0, W is not phenyl.

Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.

Abstract: Described herein are ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

Abstract: Provided are compounds having the general structure according to Formula (I): Further provided are pharmaceutical compositions comprising these compounds. The invention still further provides methods of treating alcoholism, methods of reducing alcohol intake, methods of treating anhedonia, and methods of treating anxiety using theses compounds or the compositions containing them.

Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.

Abstract: Methods and apparatus for firing a projectile in response to a threat according to various aspects of the present invention operate in conjunction with a computer coupled to a launch system for the projectile. The computer may be configured to select the projectile from multiple available projectiles and calculate a fire control solution according to a characteristic of the selected projectile. Calculating the fire control solution may comprise deriving the fire control solution from a look-up table according to a predicted intercept point. The computer may initiate a launch of the selected projectile and provide the fire control solution to the selected projectile.

Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction. Exemplary prodrugs include the cysteine compound having the formula as well as cystine dimers thereof.

Abstract: A method of defeating an incoming missile, such as a rocket propelled grenade, includes soft launching an interceptor missile, and then using pitch over motors of the interceptor missile to alter course of the missile to a desired interception direction. By launching at a relatively slow speed, such as a speed less than or equal to 40 m/sec (130 ft/sec), the interceptor missile may reach the desired interception direction within 250 milliseconds of launch. The interceptor missile may be able to cover substantially all interception directions over a hemisphere or greater extent around a launch location. For example, the interceptor missile may be launched vertically from a ground vehicle, and be capable of altering course to any above-ground trajectory within 250 milliseconds.

Abstract: A method of defeating an incoming missile, such as a rocket propelled grenade, includes soft launching an interceptor missile, and then using pitch over motors of the interceptor missile to alter course of the missile to a desired interception direction. By launching at a relatively slow speed, such as a speed less than or equal to 40 m/sec (130 ft/sec), the interceptor missile may reach the desired interception direction within 250 milliseconds of launch. The interceptor missile may be able to cover substantially all interception directions over a hemisphere or greater extent around a launch location. For example, the interceptor missile may be launched vertically from a ground vehicle, and be capable of altering course to any above-ground trajectory within 250 milliseconds.

Abstract: A method of controlling flight of a missile includes using gyroscopes, such as pitch rate gyroscopes, to sense when a factor based on the angular rate of change of the missile exceeds a threshold value. One the threshold value is exceeded, a decision may be made to use one or more compensation thrusters to reduce the angular rate of change. The use of the compensation thrusters may correct residual angular velocities from a pitch over maneuver used to put the missile on an intended course. In addition, the compensation thrusters may be used to compensate for errors in missile heading induced after the pitch over maneuver, such as induced by misalignment of thrust provided by a main rocket motor of the missile. Multiple compensation thrusters may be used to compensate for angular changes in the pitch and yaw directions.

Abstract: A reliable and inexpensive attitude control system uses a plurality of pitch-over thrusters to perform rapid and precise attitude maneuvers for a flight vehicle. The pitch-over thrusters create rotational moments that directly pitch and yaw the flight vehicle. The use of very simple thrusters and control techniques provides for a reliable and cost effective solution. The ability to perform overlapping pitch and yaw maneuvers with single-shot fixed-impulse thrusters provides for high-speed maneuverability. Although this approach is applicable to provide attitude control for any flight vehicle including all types of missiles, kill-vehicles and space craft, it is particularly applicable for smaller highly maneuverable cost-constrained missile systems. One such system is an “Active Protection System” or APS in which a missile system is integrated with a vehicle such as a HumVee or armored personnel carrier to provide defensive counter-measures against possible attack.