Patents by Inventor James M. Coull

James M. Coull has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190298857
    Abstract: This invention pertains to the field of biopolymer-loaded (where the biopolymer(s) are active pharmaceutical ingredient(s) (API(s)) polymer-based nanoparticles formulated, for example, for curative, therapeutic prophylactic and/or diagnostic applications. The polymer used to formulate the nanoparticles can be any biodegradable synthetic polymer or combination of polymers, including combinations of PLGA and PEG. Biopolymers used as active pharmaceutical ingredients (API) can include natural and unnatural nucleic acids such as DNA, RNA and LNA. Biopolymers used as active pharmaceutical ingredients (APIs) can also include neutral and positively charged nucleic acid mimics (NPNAM) such as for example, peptide nucleic acids, morpholinos, pyrrolidine-amide oligonucleotide mimics, morpholinoglycine oligonucleotides and methyl phosphonates and derivatives thereof. In some embodiments, the nanoparticles are loaded with both nucleic acids and NPNAMs as the APIs.
    Type: Application
    Filed: January 9, 2019
    Publication date: October 3, 2019
    Inventors: Bo Ying, James M. Coull, Derek Sim
  • Publication number: 20190055190
    Abstract: The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester Acid Salts, as described below) that can be used to prepare PNA monomers wherein said PNA monomers can be used to prepare said PNA oligomers. In some embodiments, the disclosure features sulfonic acid salts of Backbone Ester compounds, which sulfonic acid salts generally tend to be crystalline and can be obtained in reasonably good yield, often without requiring any chromatographic purification of the reaction product of the Backbone Ester synthesis reaction. This disclosure also pertains to novel methods for the synthesis of said Backbone Ester compounds and novel methods for the formation of the related sulfonic acid salts.
    Type: Application
    Filed: July 17, 2018
    Publication date: February 21, 2019
    Inventors: James M. Coull, Brian D. Gildea
  • Publication number: 20180282375
    Abstract: This application pertains to orthogonally protected esters of peptide nucleic acid (PNA) monomers, which ester groups can be removed under conditions that permit typical backbone and side chain acid- and base-labile protecting groups to remain substantially intact thereby permitting the high yield of PNA monomer carboxylic acids that are suitable for use in PNA oligomer synthesis. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethyl (TCE), 2,2,2-tribromoethyl (TBE), 2-bromoethyl (2-BE) and 2-iodoethyl groups (2-IE). This invention also pertains to novel methods for the synthesis of Backbone Ester compounds and related Backbone Ester Acid Salts.
    Type: Application
    Filed: March 23, 2018
    Publication date: October 4, 2018
    Inventors: Brian D. Gildea, James M Coull
  • Publication number: 20180171391
    Abstract: This invention is directed to methods and compositions for sorting and/or determining microscopic organisms or cells. The methods and compositions are directed to the use of molecular probes to selectively stain the organisms or cells in combination with the use of binding partners to selectively immobilize the stained organisms or cells to a solid carrier. By combining the selectivity of both molecular probes and binding partners in an orthogonal method for staining and immobilization, these methods and compositions increase both the discriminating power of the assays and/or the certainty of the result obtained therefrom.
    Type: Application
    Filed: February 7, 2018
    Publication date: June 21, 2018
    Inventors: James M. COULL, Henrik STENDER, Brian D. GILDEA
  • Publication number: 20160060688
    Abstract: This invention pertains to identifying one or more hybridization probes sequestered within (or optionally released from the intact) cells or microorganisms by mass spectrometry to thereby determine a trait of the cells or microorganisms and/or to identify the cells or microorganisms themselves. The cells or microorganisms can come from a subject and the information obtained from the mass spectrometry analysis may, if clinically relevant, optionally be used to diagnose and/or treat the subject.
    Type: Application
    Filed: June 10, 2015
    Publication date: March 3, 2016
    Applicant: ADVANDX, INC.
    Inventors: James M. Coull, Martin Fuchs, Mark J. Fiandaca, Alisha Perelta, Jan Trnovsky
  • Publication number: 20150344939
    Abstract: This invention is directed to methods and compositions for sorting and/or determining microscopic organisms or cells. The methods and compositions are directed to the use of molecular probes to selectively stain the organisms or cells in combination with the use of binding partners to selectively immobilize the stained organisms or cells to a solid carrier. By combining the selectivity of both molecular probes and binding partners in an orthogonal method for staining and immobilization, these methods and compositions increase both the discriminating power of the assays and/or the certainty of the result obtained therefrom.
    Type: Application
    Filed: June 15, 2015
    Publication date: December 3, 2015
    Inventors: James M. COULL, Henrik Stender, Brian D. Gildea
  • Publication number: 20140315733
    Abstract: This invention is directed to methods and compositions for sorting and/or determining microscopic organisms or cells. The methods and compositions are directed to the use of molecular probes to selectively stain the organisms or cells in combination with the use of binding partners to selectively immobilize the stained organisms or cells to a solid carrier. By combining the selectivity of both molecular probes and binding partners in an orthogonal method for staining and immobilization, these methods and compositions increase both the discriminating power of the assays and/or the certainty of the result obtained therefrom.
    Type: Application
    Filed: December 6, 2013
    Publication date: October 23, 2014
    Applicant: BOSTON PROBES, INC.
    Inventors: James M. COULL, Henrik STENDER, Brian D. GILDEA
  • Patent number: 8569304
    Abstract: In some embodiments, this invention pertains to active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof. In some embodiments, this invention pertains to methods for the preparation of active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: October 29, 2013
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar Dey, Darryl J. C. Pappin, Subhasish Purkayastha, Sasi Pillai, James M. Coull
  • Publication number: 20130084561
    Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.
    Type: Application
    Filed: May 9, 2012
    Publication date: April 4, 2013
    Inventors: James M. Coull, Andrew M. Stern, Lawrence A. Haff, Barbara S. Fox, Yumei Huang
  • Publication number: 20120329660
    Abstract: This invention is directed to methods and compositions for sorting and/or determining microscopic organisms or cells. The methods and compositions are directed to the use of molecular probes to selectively stain the organisms or cells in combination with the use of binding partners to selectively immobilize the stained organisms or cells to a solid carrier. By combining the selectivity of both molecular probes and binding partners in an orthogonal method for staining and immobilization, these methods and compositions increase both the discriminating power of the assays and/or the certainty of the result obtained therefrom.
    Type: Application
    Filed: February 6, 2012
    Publication date: December 27, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: JAMES M. COULL, HENRIK STENDER, BRIAN D. GILDEA
  • Patent number: 8273706
    Abstract: This invention pertains to isobarically labeled analytes and fragment ions thereof.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: September 25, 2012
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Darryl J. C. Pappin, Subhasish Purkayastha, James M. Coull
  • Patent number: 8071388
    Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: December 6, 2011
    Assignee: Ensemble Therapeutics Corporation
    Inventors: Yumei Huang, James M. Coull
  • Publication number: 20110250596
    Abstract: This invention is directed to methods for determining amplified nucleic acid using Linear Beacons
    Type: Application
    Filed: January 13, 2011
    Publication date: October 13, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Brian D. Gildea, James M. Coull, Jens J. Hyldig-Nielsen, Mark J. Fiandaca
  • Patent number: 7968289
    Abstract: The invention provides turnover probes for use in a variety of detection assays, for example, nucleic acid detection assays. In addition, the invention provides assays, for example, nucleic acid detection assays, using such turnover probes.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: June 28, 2011
    Assignee: Ensemble Therapeutics Corporation
    Inventors: James M. Coull, Lawrence A. Haff, Joshua A. Bittker, Xiaoyu Li, Larry W. McLaughlin
  • Patent number: 7932388
    Abstract: In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: April 26, 2011
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Darryl J. C. Pappin, Sasi Pillai, James M. Coull
  • Publication number: 20110059458
    Abstract: The present invention relates compositions and methods that are useful in catalyzing DNA-Programmed Chemistry (or Nucleic Acid-templated chemistry) for use in therapeutic and diagnostic applications.
    Type: Application
    Filed: February 20, 2009
    Publication date: March 10, 2011
    Inventors: Yumei Huang, James M. Coull, David J. Livingston
  • Patent number: 7892741
    Abstract: This invention is directed to methods for determining amplified nucleic acid using Linear Beacons.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: February 22, 2011
    Assignee: Boston Probes, Inc.
    Inventors: Brian D. Gildea, James M. Coull, Jens J. Hyldig-Nielsen, Mark J. Fiandaca
  • Patent number: 7884053
    Abstract: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
    Type: Grant
    Filed: December 26, 2006
    Date of Patent: February 8, 2011
    Assignee: Boston Probes, Inc.
    Inventors: James M. Coull, Mark J. Fiandaca, Mark D. Kristjanson, Jens J. Hyldig-Nielsen, Theresa S. Creasey
  • Publication number: 20110003712
    Abstract: This invention pertains to methods, kits and compositions suitable for the detection, identification and/or quantitation of nucleic acids which are electrostatically immobilized to matrices using non-nucleotide probes which sequence specifically hybridize to one or more target sequences of the nucleic acid but do not otherwise substantially interact with the matrix. Once the nucleic acid is immobilized, the detectable non-nucleotide probe/target sequence complex, formed before or after the immobilization of the nucleic acid, can be detected, identified or quantitated under a wide range of assay conditions as a means to detect, identify or quantitate the target sequence in the sample. Because it is reversibly bound, the non-nucleotide probe/target sequence can optionally be removed from the matrix for detecting, identifying or quantitating the target sequence in the sample.
    Type: Application
    Filed: September 17, 2009
    Publication date: January 6, 2011
    Applicant: BOSTON PROBES, INC.
    Inventors: Jack T. Johansen, Jens J. Hyldig-Nielsen, Mark J. Fiandaca, James M. Coull
  • Patent number: 7851155
    Abstract: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
    Type: Grant
    Filed: December 26, 2006
    Date of Patent: December 14, 2010
    Assignee: Boston Probes, Inc.
    Inventors: James M. Coull, Mark J. Fiandaca, Mark D. Kristjanson, Jens J. Hyldig-Nielsen, Theresa S. Creasey