Patents by Inventor James M. Coull

James M. Coull has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions And Methods Pertaining To PNA Synthons And Oligomers Comprising A Universal Base
    Publication number: 20090131662
    Abstract: This invention is related to compositions and methods pertaining to PNA synthons, PNA oligomers and/or PNA/DNA Chimeras comprising a universal base.
    Type: Application
    Filed: January 23, 2009
    Publication date: May 21, 2009
    Applicant: LIFE TECHNOLOGIES CORPORATION, a Delaware Corporation
    Inventors: Birenda K. Bhattacharya, James M. Coull
  • Compositions and methods pertaining to PNA synthons and oligomers comprising a universal base
    Patent number: 7482353
    Abstract: This invention is related to compositions and methods pertaining to PNA synthons, PNA oligomers and/or PNA/DNA Chimeras comprising a universal base.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: January 27, 2009
    Assignee: Applied Biosystems Inc.
    Inventors: Birendra K. Bhattacharya, James M. Coull
  • Analysis of Encoded Chemical Libraries
    Publication number: 20090005256
    Abstract: The invention provides methods and compositions for analysis of a mixture of DNA sequences. More particularly, the invention provides methods and compositions for analysis of encoded chemical libraries having encoding nucleic acid tags (e.g., encoded chemical libraries prepared by nucleic acid-mediated chemistry) through analyzing the nucleic acid templates.
    Type: Application
    Filed: July 28, 2006
    Publication date: January 1, 2009
    Inventors: Joshua A. Bittker, James M. Coull, Edward M. Driggers
  • Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation
    Publication number: 20080269074
    Abstract: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
    Type: Application
    Filed: December 26, 2006
    Publication date: October 30, 2008
    Applicant: Applera Corporation
    Inventors: James M. Coull, Mark J. Fiandaca, Mark D. Kristjanson, Jens J. Hyldig-Nielsen, Theresa S. Creasey
  • Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation
    Publication number: 20080220987
    Abstract: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
    Type: Application
    Filed: December 26, 2006
    Publication date: September 11, 2008
    Applicant: Applera Corporation.
    Inventors: James M. Coull, Mark J. Fiandaca, Mark D. Kristjanson, Jens J. Hyldig-Nielsen, Theresa S. Creasey
  • Detection of nucleic acid using linear beacons
    Patent number: 7422852
    Abstract: This invention is directed to methods for determining amplified nucleic acid using Linear Beacons.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: September 9, 2008
    Assignee: Boston Probes, Inc.
    Inventors: Brian D. Gildea, James M. Coull, Jens J. Hyldig-Nielsen, Mark J. Fiandaca
  • Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation
    Publication number: 20080206747
    Abstract: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 28, 2008
    Applicant: Applera Coporation
    Inventors: James M. Coull, Mark J. Fiandaca, Mark D. Kristjanson, Jens J. Hyldig-Nielsen, Theresa S. Creasey
  • Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation
    Publication number: 20080125332
    Abstract: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
    Type: Application
    Filed: December 22, 2006
    Publication date: May 29, 2008
    Applicant: Applera Corporation.
    Inventors: James M. Coull, Mark J. Fiandaca, Mark D. Kristjanson, Jens J. Hyldig-Nielsen, Theresa S. Creasey
  • Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation
    Publication number: 20080085837
    Abstract: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
    Type: Application
    Filed: December 26, 2006
    Publication date: April 10, 2008
    Applicant: Applera Corporation
    Inventors: James M. Coull, Mark J. Fiandaca, Mark D. Kristjanson, Jens J. Hyldig-Nielsen, Theresa S. Creasey
  • Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
    Patent number: 7355045
    Abstract: In some embodiments, this invention pertains to isotopically enriched N-substituted piperazine acetic acids. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazine acetic acids.
    Type: Grant
    Filed: January 5, 2004
    Date of Patent: April 8, 2008
    Assignee: Applera Corporation
    Inventors: Subhakar Dey, Darryl J. C. Pappin, Subhasish Purkayastha, Sasi Pillai, James M. Coull
  • Isotopically enriched N-substituted piperazines and methods for the preparation thereof
    Patent number: 7307169
    Abstract: In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines.
    Type: Grant
    Filed: January 5, 2004
    Date of Patent: December 11, 2007
    Assignee: Applera Corporation
    Inventors: Darryl J. C. Pappin, Sasi Pillai, James M. Coull
  • Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
    Patent number: 7256275
    Abstract: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
    Type: Grant
    Filed: March 9, 2002
    Date of Patent: August 14, 2007
    Assignee: Boston Probes, Inc.
    Inventors: James M. Coull, Mark J. Fiandaca, Mark D. Kristjanson, Jens J. Hyldig-Nielsen, Theresa S. Creasey
  • Compositions for detecting target sequences
    Patent number: 7135563
    Abstract: The present invention relates to methods, kits and compositions suitable for the improved detection, quantitation and analysis of nucleic acid target sequences using probe-based hybridization assays.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: November 14, 2006
    Assignees: Boston Probes, Inc., Dako A/S
    Inventors: Kyriaki Stefano, James M. Coull, Henrik Stender, Jens J. Hyldig-Nielsen, Kenneth H. Peterson
  • Methods, kits and compositions for suppressing the binding of detectable probes to non-target sequences in hybridization assays
    Patent number: 6962778
    Abstract: This invention relates to methods, kits and compositions suitable for the improved detection, analysis and quantitation of nucleic acid target sequences using probe based hybridization assays. The invention is more specifically directed to methods, kits and compositions suitable for suppressing the binding of detectable nucleic acid probes or detectable PNA probes to non-target nucleic acid sequences in an assay for a target nucleic acid sequence to thereby improve the reliability, sensitivity and specificity of the assay. The methods, kits and compositions of this invention are particularly well suited to the detection and analysis of nucleic acid point mutations.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: November 8, 2005
    Assignee: Boston Probes, Inc.
    Inventors: James M. Coull, Jens J. Hyldig-Nielson, Sven E. Godtfredsen, Mark J. Fiandaca, Kyriaki Stefano
  • Methods, kits and compositions pertaining to PNA Molecular Beacons
    Patent number: 6949343
    Abstract: This invention is directed to methods, kits and compositions pertaining to PNA Molecular Beacons. PNA Molecular Beacons comprise self-complementary arm segments and flexible linkages that promote intramolecular or intermolecular interactions. In the absence of a target sequence, PNA Molecular Beacons facilitate efficient energy transfer between the linked donor and acceptor moieties of the probe. Upon hybridization of the probe to a target sequence, there is a measurable change in at least one property of at least one donor or acceptor moiety of the probe which can be used to detect, identify or quantitate the target sequence in a sample.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: September 27, 2005
    Assignee: Boston Probes, Inc.
    Inventors: James M. Coull, Brian D. Gildea, Jens J. Hyldig-Nielsen
  • Isobarically labeled analytes and fragment ions derived therefrom
    Publication number: 20050148087
    Abstract: This invention pertains to isobarically labeled analytes and fragment ions thereof.
    Type: Application
    Filed: May 24, 2004
    Publication date: July 7, 2005
    Inventors: Darryl J.C. Pappin, Subhasish Purkayastha, James M. Coull
  • Compositions and methods for multiplex analysis of polynucleotides
    Publication number: 20040229253
    Abstract: Provided herein are compositions and methods for the multiplex analysis and/or detection of polynucleotides having one or more distinguishable target sequences. The methods employ signal-quencher probe pairs having specific relative differential thermal melting temperatures that permit the detection of one or more target sequences on one or more polynucleotides.
    Type: Application
    Filed: February 18, 2004
    Publication date: November 18, 2004
    Inventors: Jens J. Hyldig-Nielsen, Mark J. Fiandaca, James M. Coull
  • Methods for modulating the solubility of synthetic polymers
    Patent number: 6770442
    Abstract: This invention pertains to solubility enhanced polymers and methods, kits and compositions which enhance the aqueous solubility of said polymers. One set of preferred methods, kits and compositions embody or utilize phosphorous containing synthons and are most useful for modulating the solubility of synthetic nucleic acids and synthetic nucleic acid analogs. A second set of preferred methods, kits and compositions are most useful for modulating the aqueous solubility of peptides, other polyamides and most preferably peptide nucleic acid (PNA) polymers.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: August 3, 2004
    Assignee: Boston Probes, Inc.
    Inventors: Brian D. Gildea, James M. Coull
  • Methods, compositions and libraries pertaining to PNA dimer and PNA oligomer synthesis
    Publication number: 20040142355
    Abstract: This invention pertains to the field of PNA dimer and PNA oligomer synthesis.
    Type: Application
    Filed: October 29, 2003
    Publication date: July 22, 2004
    Inventors: Ralph A. Casale, James M. Coull, Subhakar Dey, Kevin Z. Gan, Bruce A. Kowalczyk
  • Methods, compositions and libraries pertaining PNA dimer and PNA oligomer synthesis
    Publication number: 20040137469
    Abstract: This invention pertains to the field of PNA dimer and PNA oligomer synthesis.
    Type: Application
    Filed: September 5, 2003
    Publication date: July 15, 2004
    Inventors: Ralph A. Casale, James M. Coull, Subhakar Dey