Abstract: A method of detecting activity in a MEMS accelerometer captures an acceleration bias, measures acceleration at a predetermined time, calculates a change in acceleration using the measured acceleration and the acceleration bias, and compares the change in acceleration to a threshold to detect activity. A method of detecting inactivity uses a similar technique along with a timer. The method of detecting inactivity in a MEMS accelerometer captures an acceleration bias, measures acceleration at a predetermined time, calculates a change in acceleration using the measured acceleration and the acceleration bias, and compares the change in acceleration to a threshold to detect inactivity. The method further determines if the change in acceleration is less than the threshold and, if so, determines if a predetermined period of time has elapsed to detect inactivity.

Abstract: A packaging device has a core that is connected to a sheet of material by a flowable material that sets or cures to harden, such as a two part expandable polyurethane foam. The sheet of material has a plurality of cells that the flowable material enters from a partition that forms the core through an aperture or apertures formed in the sheet of material. The chemistry of the flowable material may be altered to change density, rigidity and flexibility as required by package stresses. The flowable material is effective at creating a durable attachment of the core and sheet of material for forming packaging materials such as reels.

Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

Abstract: A reel or spool package has opposing sidewalls or flanges formed of the specified or appropriate substrate and connected by a core formed of a flowable material which sets or cures to harden, such as a two part expandable polyurethane foam. The foam is applied into a partition, which may be a paper ring, by an injection and metering device. The chemistry of the flowable material may be altered to change density, rigidity and flexibility as required by package stresses. The polyurethane foam is an effective adhesive medium, thereby forming the core and connecting the sidewalls to form the package.

Abstract: The multiple compartment pill dispenser has a rotatable cap mechanism having two holes associated with the cap which are displaceable to be aligned with each of the compartments of the dispenser. There are two standard sized holes, one for small pills and one for large pills. The dial cap mechanism is used to rotate one of the two holes into alignment with a particular pill compartment and allow a pill to be dispensed therefrom. As a closure device, an alignment plate is rotatably mounted in the cap mechanism. The alignment plate also includes two different sized holes, identical in diameter, respectively, to the two holes in the cap mechanism.

Abstract: A reel or spool package has opposing sidewalls or flanges formed of the specified or appropriate substrate. A core is positioned between the sidewalls. An insert is positioned into a center aperture of the core. A flowable adhesive material may be injected through an aperture in the sidewall and into a chamber that is formed between the insert, the core and the sidewall. The material sets and bonds the core and the sidewall to form the package.

Abstract: Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.

Abstract: Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.

Abstract: A reel or spool package has opposing sidewalls or flanges formed of the specified or appropriate substrate and connected by a core formed of a flowable material which sets or cures to harden, such as a two part expandable polyurethane foam. The foam is applied into a partition, which may be a paper ring, by an injection and metering device. The chemistry of the flowable material may be altered to change density, rigidity and flexibility as required by package stresses. The polyurethane foam is an effective adhesive medium, thereby forming the core and connecting the sidewalls to form the package.

Abstract: Human insulin-like growth factor is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factor.

Abstract: Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.

Abstract: Human insulin-like growth factors is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factors.

Abstract: Disclosed are methods and compositions for increasing the expression and recovery of heterologous polypeptides secreted by cultured plant cells, including DNA constructs for high-level gene expression, seretion of heterologous polypeptides through both the plasma membrane and cell wall into the plant culture medium to facilitate protein recovery, and novel plant culture media. Recovery of secreted heterologous polypeptides from plant cell culture medium is significantly improved by including in the plant culture medium a polypeptide stabilizer such as polyvinylpyrrolidone.

Abstract: A fibrous friction material in a sheet form having a top surface and a bottom surface with at least one surface containing a mixture of from about 10 to 65% cellulose fibers, about 5 to 50% carbon fibers, about 5 to 50% activated carbon, about 1 to 20% novoloid fibers, up to 65% diatomatious earth particles, and latex in an amount sufficient to increase the strength of the said sheet, with said percentages being based on the total weight of said sheet. The material is impregnated with a thermosetting resin prior to use.

Abstract: A portable traction device primarily for application of pelvic traction can be easily transported, assembled and dismantled by a user for the self-application of traction without the need for specialized in-patient equipment. The device is carried in a padded storage bag and includes a foldable traction frame assembly on which the user lies during application of traction. Also included are a pelvic belt, traction cords and water bags to be attached to the belt as well as hip and neck support cushions, all of the components being receivable in the storage bag. The user carries the bag and sets up the device at any convenient location. A primary component of the device is a foldable frame assembly having a base plate on which the user lies during treatment and a frame at one end providing elevated cord guides over which the traction cords extend from the belt to the water bags.

Abstract: A drywall cutting tool having an elongated handle portion and an elongated blade portion, the handle portion being of cylindrical configuration over most of its length and having a tapered end and a rounded edge, and a closed loop finger guard projecting laterally from the tapered end portion of the handle. The blade portion has an inner end captured in the handle and a pointed tip, and is of substantially uniform width and thickness along its length. The tip end has a pair of inclined sharpened edges converging to form a point, and the blade has a sharpened upper longitudinal blade edge along a portion of its length and a lower longitudinal edge of the blade formed with a row of saw teeth along its entire length.

Abstract: A novel shock-absorbing and protective horseshoe comprises a composite shoe that conforms to the shape of the perimeter of the horse's hoof, and from which protrude podded cleats strategically aligned and positioned below the horn of the hoof for providing the prerequisite support for the horse. Each podded cleat has an internal air chamber, which when combined with the complying shape of the external wall partially or fully collapses or deflates the transition of material during collapse, provides a most significant degree of cushioning, thus allowing a relatively high durometer elastomer for the composition of the cleats that would not otherwise provide sufficient compressibility, but has physical properties that surmount the factors of abrasion and wear. Such hard materials are identifiable as having a low frictional resistance in comparison to highly compressible, soft elastomers.

Abstract: Human insulin-like growth factor is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factor.