Abstract: Methods of braiding using a braiding mechanism are described. The braiding mechanism includes a circular array of filament engagement elements, a mandrel extending from the center of the circular array, a plurality of actuators disposed operably about the circular array, and a rotating mechanism adapted to rotate one or more filaments. The circular array of filament engagement elements and the plurality of actuators are configured to move relative to one another. The plurality of filaments are loaded onto the mandrel and extend radially toward and contact the circumferential edge of the circular array of filament engagement elements. The plurality of actuators are operated to engage a first subset of the plurality of filaments and move the engaged filaments in a generally radial direction to a position beyond the circumferential edge of the circular array. The rotating mechanism is operated to move the engaged filaments about the mandrel axis.

Abstract: Devices and methods for treatment of a patient's vasculature are described. The device includes a self-expanding resilient permeable shell having a radially constrained state and an expanded state with a globular, axially shortened configuration. The permeable shell may be a single layer of braided elongate filaments having first and second ends that are secured at the proximal end of the permeable shell. The devices may also include permeable shells made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Methods of using the device to treat a cerebral aneurysm are also described. Methods of forming a tubular braid are also described. Methods of forming a tubular braid with variable braid densities are described. Methods of forming a tubular braid using a castellated mandrel are also described.

Abstract: A composition and method are disclosed for optimizing sperm survival and function for couples suffering from male infertility by stimulating and increasing the female sexual partner's vaginal lubrication. An increased amount of vaginal transudate is produced in the female by the topical vulval application of a composition containing menthol or a related cooling compound. The resulting increased amount of vaginal transudate can support the function and viability of the spermatozoa in the hostile vaginal environment and ultimately in the cervical mucus to both capacitate sperm in vivo and to provide a medium for gradient sperm differentiation in the vagina and cervix. The inventive composition and method provides a means to compensate for male infertility caused by abnormal semen quality in order for a couple to successfully achieve conception.

Abstract: A composition and method are disclosed for optimizing sperm survival and function for couples suffering from male infertility by stimulating and increasing the female sexual partner's vaginal lubrication. An increased amount of vaginal transudate is produced in the female by the topical vulval application of a composition containing menthol or a related cooling compound. The resulting increased amount of vaginal transudate can support the function and viability of the spermatozoa in the hostile vaginal environment and ultimately in the cervical mucus to both capacitate sperm in vivo and to provide a medium for gradient sperm differentiation in the vagina and cervix. The inventive composition and method provides a means to compensate for male infertility caused by abnormal semen quality in order for a couple to successfully achieve conception.

Abstract: Devices and methods for treatment of a patient's vasculature are described. The devices include implants made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Additionally, there is a transition zone between the two regions. The implants have a low profile radially constrained state and an expanded state that is axially shortened. Methods of using the device to treat a cerebral aneurysm are also described. Methods of forming a tubular braid are also described. Methods of forming a tubular braid with variable braid densities are described. Methods of forming a tubular braid using a castellated mandrel are also described.

Abstract: Systems for treating an aneurysm in a cerebral vessel and methods of use are described. In one embodiment, the system includes an elongate tubular member having a lumen, an expandable stent, and a delivery device. The expandable stent has a constrained state that is configured for delivery through the lumen of the elongate tubular member, and an expanded state configured for placement within the cerebral vessel adjacent the aneurysm. The delivery device includes an elongate member and a self-expandable portion. The proximal end of the self-expandable portion is coupled to the elongate member at or near the distal end of the elongate member. The self-expandable portion of the delivery device includes a tubular mesh structure having a constrained state and an expanded state. The stent is engaged (e.g., mechanical, frictional, or intermeshing) with the self-expandable portion of the delivery device.

Abstract: A method and composition for substituting menthol or a menthol related compound for parabens as a preservative agent in cosmetic and pharmaceutical compositions. The invention provides a means to make cosmetic and pharmaceutical products saber and more marketable by removing all parabens and relying on the antibiotic properties of menthol, or menthol derivatives, to provide antibiotic preservative functions.

Abstract: A composition and method are disclosed for treating orgasmic disorder in a female subject. The composition is a topical medicament containing tadalafil, menthol, and 1-arginine. The composition typically further comprises an extended release mucoadhesive polymer, and is used for topical application to the clitoris and genital tissues of a human female suffering from orgasmic disorder, which includes difficulty achieving orgasm and anorgasmia. Topical application of the inventive composition to the clitoral mucous membranes and other female genital tissues affects vasodilation and clitoral erection tier an extended period of time and compensates for low testosterone levels in a female subject.

Abstract: Methods for forming a tubular braid are described. The method for braiding includes providing a braiding mechanism including a disc, a mandrel, and a plurality of actuators. The disc defines a plane and a circumferential edge and the mandrel extends from a center of the disc. A plurality of filaments are loaded on the mandrel, each extending radially toward the circumferential edge and contacting the disc at a point of engagement. The plurality of actuators are operated to engage and move a first subset of filaments in a generally radial direction to a position beyond the circumferential edge. The disc or the engaged first subset are rotated relative to one another, thereby crossing the first subset over a second subset of filaments. The actuators are then operated to move the first subset to a radial position on the circumferential edge different from its previous point of engagement.

Abstract: Methods and devices for removing a thrombus are described. The device includes an expandable cylindrical structure made of wires and a self-expanding permeable shell located at the distal end of the cylindrical structure. Methods and devices for treating a cerebral aneurysm are described. The device may include a self-expanding resilient permeable shell and a metallic coil secured to the distal end of the permeable shell.

Abstract: Methods and devices for removing a thrombus are described. The device includes an expandable cylindrical structure made of wires and a self-expanding permeable shell located at the distal end of the cylindrical structure. Methods and devices for treating a cerebral aneurysm are described. The device may include a distal self-expanding resilient permeable shell, a proximal self-expanding resilient permeable shell, and an elongate support member positioned between the distal and proximal permeable shells. The elongate support member may be rigid or may be a coil, such as an extension spring. The distal and proximal permeable shells may be made from a plurality of braided filaments, the shells having different pore sizes. The device may also be a braided implant with a force biasing component, such as a coil or generally circular extension, attached to its distal end.

Abstract: Mechanisms and methods for forming a tubular braid are described. The mechanism for braiding includes a disc, a mandrel, a plurality of catch mechanisms, a plurality of actuators, and a computer program. The disc defines a plane and a circumferential edge. The mandrel extends from a center of the disc and is adapted to hold a plurality of filaments extending radially from the mandrel toward the circumferential edge of the disc. The plurality of catch mechanisms are positioned circumferentially around the edge of the disc and are adapted to engage a filament. The plurality of actuators are configured to move relative to one another and are adapted to move the plurality of catch mechanisms in a substantially radial direction relative to the circumferential edge of the disc.

Abstract: Methods of braiding using a braiding mechanism are described. The braiding mechanism includes a circular array of filament engagement elements, a mandrel extending from the center of the circular array, a plurality of actuators disposed operably about the circular array, and a rotating mechanism adapted to rotate one or more filaments. The circular array of filament engagement elements and the plurality of actuators are configured to move relative to one another. The plurality of filaments are loaded onto the mandrel and extend radially toward and contact the circumferential edge of the circular array of filament engagement elements. The plurality of actuators are operated to engage a first subset of the plurality of filaments and move the engaged filaments in a generally radial direction to a position beyond the circumferential edge of the circular array. The rotating mechanism is operated to move the engaged filaments about the mandrel axis.

Abstract: A braiding machine and methods of braiding are described. The braiding machine includes first and second annular members having inclined surfaces, the second annular member being concentric with the first annular member. The inclined surfaces are inclined at a non-zero angle formed between an axis of the outer ring and a horizontal axis that lies perpendicular to the longitudinal axis of the mandrel. Each of the annular members has a plurality of tubular guide wires slideably mounted thereon and a plurality of wires extend from the mandrel through each of the tubular wire guides. One of the first and second annular members rotates circumferentially relative to the other. The first plurality of tubular wire guides slides radially inward so as to align with the second annular member, and the second plurality of tubular wire guides slides radially outward so as to align with the first annular member.

Abstract: Methods and devices for removing a thrombus are described. The device includes an expandable cylindrical structure made of wires and a self-expanding permeable shell located at the distal end of the cylindrical structure. Methods and devices for treating a cerebral aneurysm are described. The device may include a distal self-expanding resilient permeable shell, a proximal self-expanding resilient permeable shell, and an elongate support member positioned between the distal and proximal permeable shells. The elongate support member may be rigid or may be a coil, such as an extension spring. The distal and proximal permeable shells may be made from a plurality of braided filaments, the shells having different pore sizes. The device may also be a braided implant with a force biasing component, such as a coil or generally circular extension, attached to its distal end.

Abstract: Devices and methods for treatment of a patient's vasculature are described. The devices include implants made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Additionally, there is a transition zone between the two regions. The implants have a low profile radially constrained state and an expanded state that is axially shortened. Methods of using the device to treat a cerebral aneurysm are also described. Methods of forming a tubular braid are also described. Methods of forming a tubular braid with variable braid densities are described. Methods of forming a tubular braid using a castellated mandrel are also described.

Abstract: Methods and devices for removing a thrombus are described. The device includes an expandable cylindrical structure made of wires and a self-expanding permeable shell located at the distal end of the cylindrical structure. Methods and devices for treating a cerebral aneurysm are described. The device may include a distal self-expanding resilient permeable shell, a proximal self-expanding resilient permeable shell, and an elongate support member positioned between the distal and proximal permeable shells. The elongate support member may be rigid or may be a coil, such as an extension spring. The distal and proximal permeable shells may be made from a plurality of braided filaments, the shells having different pore sizes. The device may also be a braided implant with a force biasing component, such as a coil or generally circular extension, attached to its distal end.

Abstract: Mechanisms and methods for forming a tubular braid are described. The mechanism for braiding includes a disc, a mandrel, a plurality of catch mechanisms, a plurality of actuators, and a computer program. The disc defines a plane and a circumferential edge. The mandrel extends from a center of the disc and is adapted to hold a plurality of filaments extending radially from the mandrel toward the circumferential edge of the disc. The plurality of catch mechanisms are positioned circumferentially around the edge of the disc and are adapted to engage a filament. The plurality of actuators are configured to move relative to one another and are adapted to move the plurality of catch mechanisms in a substantially radial direction relative to the circumferential edge of the disc.

Abstract: A braiding machine and methods of braiding are described. The braiding machine includes first and second annular members having inclined surfaces, the second annular member being concentric with the first annular member. The inclined surfaces are inclined at a non-zero angle formed between an axis of the outer ring and a horizontal axis that lies perpendicular to the longitudinal axis of the mandrel. Each of the annular members has a plurality of tubular guide wires slideably mounted thereon and a plurality of wires extend from the mandrel through each of the tubular wire guides. One of the first and second annular members rotates circumferentially relative to the other. The first plurality of tubular wire guides slides radially inward so as to align with the second annular member, and the second plurality of tubular wire guides slides radially outward so as to align with the first annular member.

Abstract: Devices and methods for forming a tubular braid comprising a plurality of filaments. The method for braiding includes the step of loading a plurality of filaments on a mandrel and extending the filaments radially from the mandrel, the plurality of filaments have a first subset and a second subset. Tension is applied to the plurality of filaments using a weight attached to each filament. The first subset of the plurality of filaments is engaged, moved circumferentially relative to the second subset, and then released. The second subset of filaments is then engaged and moved circumferentially relative to the first subset of filaments, such that a tubular braid of filaments is formed.