Abstract: The invention provides methods of dosing for the treatment of cancers, such as multiple myelomas, with anti-fragment crystallizable receptor-like 5 (FcRH5)/anti-cluster of differentiation 3 (CD3) bispecific antibodies.

Abstract: Force transducers for use in electrostatic drivers, including electrostatic drivers that can be utilized in loudspeaker systems that utilize drivers having a magnetic negative spring (MNS) (such as reluctance assist drivers (RAD) and permanent magnet crown (PMC) drivers). The electroacoustic drivers having the force transducers can be used at all audio frequencies, including subwoofer frequencies.

Abstract: The present disclosure provides methods and compositions related to the modification of immune effector cells to increase therapeutic efficacy. In some embodiments, immune effector cells modified to reduce expression of one or more endogenous target genes, or to reduce one or more functions of an endogenous protein to enhance effector functions of the immune cells are provided. In some embodiments, immune effector cells further modified by introduction of transgenes conferring antigen specificity, such as exogenous T cell receptors (TCRs) or chimeric antigen receptors (CARs) are provided. Methods of treating a cell proliferative disorder, such as a cancer, using the modified immune effector cells described herein are also provided.

Abstract: According to some aspects, there is provided systems and methods for monitoring extraction of landfill gas from a landfill having a plurality of wells by using a communication system configured to transmit information using a low-power wide area networking (LPWAN) protocol, the communication system comprising one or more gateway devices including a first gateway device and a plurality of communication node devices including a first communication node device. Further, there is provided methods for configuring a communication system comprising one or more gateway devices including a first gateway device and multiple communication node devices including a first communication node device.

Abstract: A method performed by a device registration server is disclosed. The method may include receiving, from a mobile device, location information and data associated with at least one image displayed on at least one display coupled to and co-located with a device, the image being captured by the mobile device. The location information may indicate a location of the mobile device when the at least one image was captured by the mobile device. The method may further include determining that the data received from the mobile device includes device information associated with the device. The method may also include registering the device coupled to and co-located with the at least one display based on the location information and the data received from the mobile device.

Abstract: A pointing controller enables interaction with virtual objects in a virtual or augmented reality environment. The pointing controller comprises a form factor that enables it to be securely positioned in the user's fingers during a pointing gesture. The pointing controller tracks a pointing direction in three-dimensional space based on motion of the pointing controller. The pointing controller furthermore includes one or more control elements such as buttons or touch interfaces to enable additional interactions.

Abstract: A security enclosure, components thereof, and associated methods. In one embodiment, the security enclosure is sized and shaped to hold a firearm, and the security enclosure can be used with a monitor and an associated magnet. The security enclosure system includes first and second enclosure portions movable with respect to one another to open and close the system. The first enclosure portion includes a first holder, the second enclosure portion includes a second holder, and at least one of the first or second holders holds the security monitor in an interior when the enclosure is closed. The other of the at least one of the first or second holders holds the magnet in the interior when the enclosure is closed. The first and second holders are adjacent to each other when the enclosure is closed and are spaced apart from each other when the enclosure is open.

Abstract: The invention relates to a cryogenic refrigeration device comprising an enclosure delimiting a fluidtight vacuum volume closed by a cover, the device comprising at least one cryogenic cooler mounted through the cover and of the type that employs a cold source of cryogenic-cycle fluid such as helium, the device comprising at least one heat-conducting plate intended to receive and cool a component and cooled by a stream of cycle fluid via a cycle-fluid circuit supplying a set of heat exchangers, the cycle-fluid circuit having a pipe conveying cycle fluid first of all to a manifold mounted on the plate, the cycle-fluid circuit having at least one transfer pipe configured to transfer cycle fluid from the manifold to at least one heat exchanger mounted on the same plate, the cycle-fluid circuit having at least one return pipe configured to return fluid that has circulated through the at least one heat exchanger to the manifold.

Abstract: Systems and methods are provided for facilitating continuous affinity-based separation of phases in multi-phase formation fluid in a downhole environment. A system can comprise a formation sampler that samples a formation to gather multi-phase formation fluid in a continuous flow through a wellbore during a testing pump out of the formation. The system can also comprise a phase separator comprising one or more affinity-based separators that continuously separates one or more phases of the multi-phase formation fluid through either or both diffusion or flow while downhole in the wellbore during the testing pump out.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: An elevator system having a hoistway having a bottom landing with landing doors. An elevator car is in the hoistway, and a safety chain is coupled to the car and is in an open-state to stop the car and otherwise in an intact-state. A first sensor wirelessly transmits a first signal when the car is at the bottom landing, and a second sensor transmits a second signal when the doors are open. The system includes a control circuit including a first control element that receives the first signal indicating the car is at the bottom landing and a second control element that receives the second signal indicating the landing doors are open, and the control circuit changes state upon receipt of the signals, and the safety chain transitions to the open-state from the intact state when the control circuit changes state.

Abstract: A computer-implemented method of analysing transcript data, comprising: receiving a plurality of transcripts and a set of outcome data for each transcript, the outcome data associating each transcript with one or more outcomes; receiving a query transcript; processing the query transcript and each transcript within the plurality of transcripts; comparing, the processed data representing the query transcript with the processed data representing the plurality of transcripts, to identify a subset of the plurality of transcripts that meet a threshold similarity criterion with respect to the query transcript; and thereby determining a relationship between the query transcript and one or more outcomes.

Abstract: A controller may use a timing model to control and coordinate the execution of components within a data processing pipeline. The timing model may be generated based on log data collected during execution of the components, to model component latencies and pipeline behavior in a production environment. The controller may use the timing model to control the timing of the inputs to, the outputs from, and the execution of various interacting components in the data processing pipeline. The timing model may include component-specific and/or channel-specific timing data, and in various implementations may be based on inputs provided to the components, the timing and contents of outputs from the components, and/or the number of times particular code is executed within the components.

Abstract: Methods and apparatuses control light emitted from a mirror platform through an interaction with a user. A first signal is received from a capacitive sensor during the interaction. The capacitive sensor is incorporated on the back side of the mirror platform. The first signal is processed to obtain control parameters for at least two light sources. The at least two light sources are configured with the mirror platform and the at least two light sources produce light at different color temperatures. The control parameters are used to cause the at least two light sources to emit light at a color temperature established during the interaction.

Abstract: Electroacoustic drivers that can be utilized in loudspeaker systems that utilize drivers having a magnetic negative spring (MNS) (such as reluctance assist drivers (RAD) and permanent magnet crown (PMC) drivers). The electroacoustic drivers can be used at all audio frequencies, including subwoofer frequencies. The magnetic negative springs of the electroacoustic drivers can cancel, or partially cancel, the large pressure forces on a sound panel (of an audio speaker) so that substantial subwoofer notes can be efficiently and cost effectively produced in small/portable speakers. The electroacoustic drivers can include a stabilizing/centering mechanism to overcome the destabilizing forces of a MNS that are too large for a voice coil alone to produce.

Abstract: An improved debris catcher and choke system for receiving a pressurized fluid stream from wellbore operations where a controller can selectively place a plurality of debris catchers in debris catching or flushing modes, and the cleaned fluids from one of the debris catchers can be used to flush one of the other debris catchers. One or more embodiments relate to systems and methods for utilizing debris catchers and choke valves.

Abstract: A method for preparing a geothermal system involves preparing a wellbore that extends into an underground magma reservoir. Characteristics of the drilling process and the borehole are monitored to detect when the magma reservoir is reached, such that specially configured drilling operations can be performed to drill to a target depth within the magma reservoir.

Abstract: The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

Abstract: An enclosure for use as a walk-in freezer or refrigerator, or as a commercial or residential controlled environment building structure includes a first panel and a second panel connected to the first panel. Each of the first and second panels includes a body having a joining beam adhered to the body. The joining beam is comprised of structural material. One or more interior edges of the joining beam are embedded into the panel insulating foam body. An exterior edge of the embedded joining beam defines a joining profile. The joining profile of the first panel may define a groove, and the joining profile of the second panel may define a protrusion configured to engage the groove of the joining member of the first panel. Joined panels may comprise a portion or all of the floor, walls, and ceiling/roof elements of a controlled environment building/enclosure.

Abstract: An insertion catheter for a circulatory support catheter having a circulatory support device carried by an elongate flexible catheter shaft. The insertion catheter comprises a tubular body with a distal portion configured to axially movably receive the circulatory support device. A diameter of the distal portion is greater than a diameter of a mid portion of the tubular body. The insertion catheter may be inserted into an introducer sheath for delivery of the MCS device. A distal end of the insertion catheter may be located distally of a distal end of the introducer sheath and distally of the arterial bifurcation. The distal portion of the insertion catheter containing the MCS device may be located distally of the bifurcation, with a distal end of the MCS device slightly offset from the distal end of the tubular body.