Abstract: The present disclosure provides methods and compositions related to the modification of immune effector cells to increase therapeutic efficacy. In some embodiments, immune effector cells modified to reduce expression of one or more endogenous target genes, or to reduce one or more functions of an endogenous protein to enhance effector functions of the immune cells are provided. In some embodiments, immune effector cells further modified by introduction of transgenes conferring antigen specificity, such as exogenous T cell receptors (TCRs) or chimeric antigen receptors (CARs) are provided. Methods of treating a cell proliferative disorder, such as a cancer, using the modified immune effector cells described herein are also provided.

Abstract: A vehicle panel includes channels, wherein a first channel includes a first wire capable and a second channel includes a second wire and each wire is capable of carrying at least one of power or a vehicle data signal. The panel also includes a connection point connectable to at least one of a battery or a vehicle computing system, wherein selection of connection between the vehicle computing system or battery to a given connection point provided to a given one of the first or second channels dictates whether the channel carries the vehicle data signal or power. Also, the panel includes holes connecting to the first wire and at least two of the holes connecting to the second wire allowing a connection probe to be inserted into a respective hole to connect to a wire included in a channel to which the hole connects.

Abstract: A method for automatically replacing a first type of content associated with a real-time broadcast with a second type of content is provided. The method may include automatically parsing media content associated with the real-time broadcast and assigning timecode to the parsed media content. The method may further include determining whether the parsed media content includes the first type of content. The method may further include, in response to determining the parsed media content includes the first type of content, automatically determining a context associated with the first type of content. The method may further include automatically identifying the second type of content that matches the determined context. The method may also include, automatically replacing the first type of content in the parsed media content with the second type of content. The method may further include automatically presenting the real-time broadcast with the second type of content.

Abstract: Systems and methods use a three-dimensional snapshot of an infant, child, adolescent, or adult where the subject may have bent legs and an unaligned head position, to provide an estimate of human length. The system identifies anatomical features from the digital information and generates a virtual skeleton. The cumulative distances between pseudo-joints of the virtual skeleton provide an estimate of human length. Comparing length estimates from multiple three-dimensional snapshots of the same individual acquired over time provide an indication of growth of the infant, child, or adolescent. Daily estimates of length can detect growth faltering sooner than less frequent estimates of length, which can lead to timely intervention.

Abstract: Systems and methods for beam profile imaging by emitting a ray into one or more media; receiving a first signal corresponding to the ray at a first point; encoding a first matrix based at least in part on one or more of a location of the first point, a direction of the ray at the first point, and a first perturbation effect; receiving a second signal corresponding to the ray at a second point; encoding a second matrix based at least in part on one or more of a location of the second point, a direction of the ray at the second point, and a second perturbation effect; and calculating the value of the acoustic property of one or more media based at least in part on a comparison between the first matrix and the second matrix.

Abstract: A system and method for transport management includes a back-end system controlling a display depicting real-time location tracking for drivers or commodities requiring location tracking, route status tracking for driveaway vehicles and towable unites, and freight using a location tracking device including a GPS device connected to a cloud-based infrastructure.

Abstract: A respiratory ventilation apparatus configured to deliver a respiratory gas to a patient interface is provided. The apparatus may include a gas pressurization unit configured to generate a pressurized respiratory gas, a gas inlet port configured to introduce the respiratory gas into the respiratory ventilation apparatus, a gas outlet port configured to discharge the pressurized respiratory gas to a respiration tube, a detection module configured to detect the pressure of the pressurized respiratory gas, at least one non-volatile memory configured to store a plurality of parameters and a plurality of programs, and one or more controllers. The one or more controllers may be configured to initiate the respiratory ventilation apparatus upon a boot operation, and/or initiate a program that constantly reads information from the detection module, and controls the pressure of the pressurized respiratory gas using the information read from the detection module and at least one parameter.

Abstract: An electronic control unit comprises circuitry to receive a combined signal via a vehicle bus of a vehicle, wherein the combined signal contains a combination of a data signal and a watermark signal, which can be a radio frequency (RF) signal or an analog baseband signal, wherein the data signal includes a message, circuitry to extract a watermark from the watermark signal, circuitry to verify the watermark based on a comparison of the watermark with a pre-defined watermark, circuitry to extract the data signal from the combined signal and obtain the message from the data signal, and circuitry to authenticate the message based on the verification of the watermark.

Abstract: A pointing controller enables interaction with virtual objects in a virtual or augmented reality environment. The pointing controller comprises a form factor that enables it to be securely positioned in the user's fingers during a pointing gesture. The pointing controller tracks a pointing direction in three-dimensional space based on motion of the pointing controller. The pointing controller furthermore includes one or more control elements such as buttons or touch interfaces to enable additional interactions.

Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which the aryl hydrocarbon receptor (AHR) is implicated, by the administration of small molecule therapeutics which act as inhibitors of AHR.

Abstract: Apparatuses, systems, and techniques to perform one or more APIs. In at least one embodiment, a processor is to perform an API to indicate a number of 5G-NR cells that are able to be performed concurrently by one or more processors; a processor is to perform an API to indicate whether one or more processors are able to perform a first number of 5G-NR cells concurrently; a processor comprising one or more circuits is to perform an API to indicate whether one or more resources of one or more processors are allocated to perform 5G-NR cells; and/or a processor comprises one or more circuits to perform an API to indicate one or more techniques to be used by one or more processors in performing one or more 5G-NR cells.

Abstract: Apparatuses, systems, and techniques to perform one or more APIs. In at least one embodiment, a processor is to perform an API to indicate a number of 5G-NR cells that are able to be performed concurrently by one or more processors; a processor is to perform an API to indicate whether one or more processors are able to perform a first number of 5G-NR cells concurrently; a processor comprising one or more circuits is to perform an API to indicate whether one or more resources of one or more processors are allocated to perform 5G-NR cells; and/or a processor comprises one or more circuits to perform an API to indicate one or more techniques to be used by one or more processors in performing one or more 5G-NR cells.

Abstract: Apparatuses, systems, and techniques to perform one or more APIs. In at least one embodiment, a processor is to perform an API to indicate a number of 5G-NR cells that are able to be performed concurrently by one or more processors; a processor is to perform an API to indicate whether one or more processors are able to perform a first number of 5G-NR cells concurrently; a processor comprising one or more circuits is to perform an API to indicate whether one or more resources of one or more processors are allocated to perform 5G-NR cells; and/or a processor comprises one or more circuits to perform an API to indicate one or more techniques to be used by one or more processors in performing one or more 5G-NR cells.

Abstract: Apparatuses, systems, and techniques to perform one or more APIs. In at least one embodiment, a processor is to perform an API to indicate a number of 5G-NR cells that are able to be performed concurrently by one or more processors; a processor is to perform an API to indicate whether one or more processors are able to perform a first number of 5G-NR cells concurrently; a processor comprising one or more circuits is to perform an API to indicate whether one or more resources of one or more processors are allocated to perform 5G-NR cells; and/or a processor comprises one or more circuits to perform an API to indicate one or more techniques to be used by one or more processors in performing one or more 5G-NR cells.

Abstract: The present invention provides a method of manufacturing a coral scaffold for use as a bone graft substitute. The method comprises growing coral in a growth medium having a carbonate hardness, dKH, of 10 or more; removing at least a portion of the coral from the growth medium; devitalising coral removed from the growth medium and sizing the devitalised coral to form the coral scaffold.

Abstract: A network adapter comprises an output that couples to a central processing unit (CPU) of a network device, a first clock coupled to the output and configured to be synchronized with a second clock that is external to the CPU and the network adapter, and circuitry coupled to the first clock. The circuitry is configured to generate, using the synchronized first clock, a tick at a time offset from a timeslot of a radio schedule for a radio unit and send the tick to the output.

Abstract: A cut resistant and highly translucent tote utilizes a multilayer knitted metal fabric having a knitted metal outside layer and a knitted metal inside layer. These two knitted layers may be independent in a portion of the tote, such as in a clear-view portion of the tote, configured to allow clear visibility of items retained in the tote. The independent layers of knitted fabric are highly cut resistant, as they can flex in multiple direction and also move and slide with respect to each other. The tote may have a gusseted base with a base-side sleeve extending at the intersection of the base and sides to allow the tote to be free standing. An opening in the top of the tote may have a closure feature, such as hook-and-loop fastener material.

Abstract: A method may comprise positioning a downhole fluid sampling tool into a wellbore; performing a pressure test operation within the wellbore; performing a pumpout operation within the wellbore; identifying one or more formation parameters at least in part from the at least one pressure test operation or the at least one pumpout operation; building a correlation model that relates a pumpout trend to the one or more formation parameters; determining a time when the downhole fluid sampling tool takes a clean fluid sample utilizing at least the correlation model; and acquiring the clean fluid sample with the downhole fluid sampling tool from the wellbore. Additionally, a system may comprise a downhole fluid sampling tool configured to: perform a pressure test operation within a wellbore; and perform a pumpout operation within the wellbore.

Abstract: A model is used to generate corrections to mitigate ideal condition artifacts in acoustic property values of an annular material in a cased wellbore. A mathematical model that generates acoustic property values at ideal conditions introduces artifacts into the acoustic property values. Acoustic measurements of an annular material are used to generate features that represent wellbore conditions and are not accounted for in the mathematical model that generates acoustic property values. A model will generate corrections for acoustic property values of an annular material with the features to yield a more accurate acoustic property profile for the annular material of a cased hole.

Abstract: A method performed by a device registration server is disclosed. The method may include receiving, from a mobile device, location information and data associated with at least one image displayed on at least one display coupled to and co-located with a device, the image being captured by the mobile device. The location information may indicate a location of the mobile device when the at least one image was captured by the mobile device. The method may further include determining that the data received from the mobile device includes device information associated with the device. The method may also include registering the device coupled to and co-located with the at least one display based on the location information and the data received from the mobile device.