Abstract: The present invention provides novel nucleic acid compound suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.

Abstract: Video monitoring and alarm verification technology, in which a first connection is established between a first device and a camera located in a monitored property associated with a user of the first device and image data captured by the camera is received over the first connection and at the first device. A determination is made to establish a second connection with a second device that enables sharing of the received image data with the second device and, in response to the determination, the second connection is established between the first device and the second device. The received image data is shared with the second device over the second connection and the second device is restricted from directly accessing image data captured by the camera located in the monitored property.

Abstract: The present invention relates to inhibitors, and compositions containing inhibitors, and uses of the same in the treatment or prevention of diabetes.

Abstract: In some implementations, a computing device may include receiving one or more measurements of drilling parameters. In addition, the computing device may include accessing historical drilling logs for one or more wells in a geographic region. Also, the computing device may include training, using one or more processors, a machine learning model to determine predicted values for a triple combo log for a new well in the geographic region. Further, the computing device may include determining, using the one or more processors, one or more formation properties from the triple combo log. In addition, the computing device may include determining, using the one or more processors, an adjustment to one or more drilling parameters based at least on the one or more formation properties. The adjustment can be applied to a drilling process on a drilling rig.

Abstract: Method and system for storing and/or transporting temperature-sensitive materials. In one embodiment, the system is designed for use as a dry ice shipper and includes an outer box, a vacuum insulated panel (VIP) base assembly, a VIP lid assembly, and a gas flow director. The VIP base assembly is positioned within the outer box and includes five VIPs arranged to form a container having a bottom, four sides, and an open top. The VIP lid assembly, which may be coupled to a top closure flap of the outer box, includes a VIP dimensioned to close the open top of the VIP base assembly. The gas flow director, which may comprise a bag having an opening at its top end, may be positioned within the outer box and may be used to receive the VIP base assembly. The gas flow director inhibits convective gas flow that promotes excessive dry ice sublimation.

Abstract: The invention provides compounds of Formula (1), or pharmaceutically acceptable salts The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

Abstract: A system and method for managing data share requests. An electronic form processing module receives a request to share data relating to an organization with an entity not affiliated with the organization. The request includes responses to questions presented in an electronic form. At least some of the questions presented in the electronic form are presented based on a response to a previously asked question in the electronic form. A score calculation module calculates a score based on the responses to the questions presented in the electronic form. A risk analysis module determines whether to approve, deny or escalate the request to share databased on the score.

Abstract: Isolated antibodies which specifically bind to UNC5C protein and mimic and/or compete with Netrin-1 for binding to UNC5C are disclosed. Related products and uses including therapeutic uses in the treatment of neurodegenerative disorders are also disclosed.

Abstract: Methods of encoding and decoding are described which use a variable number of instruction words to encode instructions from an instruction set, such that different instructions within the instruction set may be encoded using different numbers of instruction words. To encode an instruction, the bits within the instruction are re-ordered and formed into instruction words based upon their variance as determined using empirical or simulation data. The bits in the instruction words are compared to corresponding predicted values and some or all of the instruction words that match the predicted values are omitted from the encoded instruction.

Abstract: A live media streaming system and method is presented herein. The system and method includes broadcasting a live media stream in at least one of a plurality of themed broadcasting channels, the live media stream being transmitted from a broadcasting device corresponding to a broadcasting user. A jump zone (a physical region or area) is selected or defined based upon predetermined jump zone criteria corresponding to the at least one of the plurality of themed broadcasting channels. Further, a next broadcasting user is selected, wherein the user is located within the physical geographic region of the jump zone. Once the next broadcasting user is selected, a live media stream is broadcasted from the next user's broadcasting device.

Abstract: A method of forming a batch of shaped adsorbent particles may include applying a precursor mixture into a shaping assembly within an application zone to form a batch of precursor shaped adsorbent particles, drying the batch of precursor shaped adsorbent particles within the shaping assembly to form the batch of shaped adsorbent particles, and ejecting the batch of shaped adsorbent particles from the shaping assembly. The batch of shaped adsorbent particles may have a moisture content of at least about 20 wt. %.

Abstract: An exhaust gas recirculation ejector system for an engine that includes an air conduit coupled to an engine providing charge air to the engine. The air conduit includes at least one bend formed therein. The at least one bend includes a port formed therein. An EGR conduit is coupled to an exhaust manifold of the engine at a first end of the EGR conduit. A second end of the EGR conduit passes through the port and extends into the air conduit at the bend defining an ejector mixing the charge air and exhaust gas before entry into the engine. A pressure sensor is positioned in the bend indicating a pressure of EGR gas exiting the bend.

Abstract: Methods of encoding and decoding are described which use a variable number of instruction words to encode instructions from an instruction set, such that different instructions within the instruction set may be encoded using different numbers of instruction words. To encode an instruction, the bits within the instruction are re-ordered and formed into instruction words based upon their variance as determined using empirical or simulation data. The bits in the instruction words are compared to corresponding predicted values and some or all of the instruction words that match the predicted values are omitted from the encoded instruction.

Abstract: A system and method for managing data share requests. An electronic form processing module receives a request to share data relating to an organization with an entity not affiliated with the organization. The request includes responses to questions presented in an electronic form. At least some of the questions presented in the electronic form are presented based on aresponse to a previously asked question in the electronic form. A score calculation module calculates a score based on the responses to the questions presented in the electronic form. A risk analysis module determines whether to approve, deny or escalate the request to share databased on the score.

Abstract: Methods of encoding and decoding are described which use a variable number of instruction words to encode instructions from an instruction set, such that different instructions within the instruction set may be encoded using different numbers of instruction words. To encode an instruction, the bits within the instruction are reordered and formed into instruction words based upon their variance as determined using empirical or simulation data. The bits in the instruction words are compared to corresponding predicted values and some or all of the instruction words that match the predicted values are omitted from the encoded instruction.

Abstract: A system and method for managing data share requests. An electronic form processing module receives a request to share data relating to an organization with an entity not affiliated with the organization. The request includes responses to questions presented in an electronic form. At least some of the questions presented in the electronic form are presented based on a response to a previously asked question in the electronic form. A score calculation module calculates a score based on the responses to the questions presented in the electronic form. A risk analysis module determines whether to approve, deny or escalate the request to share data based on the score.

Abstract: An exhaust gas recirculation ejector system for an engine that includes an air conduit coupled to an engine providing charge air to the engine. The air conduit includes at least one bend formed therein. The at least one bend includes a port formed therein. An EGR conduit is coupled to an exhaust manifold of the engine at a first end of the EGR conduit. A second end of the EGR conduit passes through the port and extends into the air conduit at the bend defining an ejector mixing the charge air and exhaust gas before entry into the engine.

Abstract: A method for jumping cylinder deactivation (“CDA”) modes to avoid a primary powertrain resonant frequency in a six-cylinder diesel engine-powered machine comprises operating an engine between an idled condition and a first engine speed limit in one of a two-cylinder CDA mode or a four-cylinder CDA mode. The method operates the engine between the first engine speed limit and a second engine speed limit in a three-cylinder CDA mode. The first engine speed limit is an engine speed below which the two-cylinder or four-cylinder CDA mode causes the machine to operate below a primary powertrain resonant frequency and also above which the three-cylinder CDA mode causes the machine to operate above the primary powertrain resonant frequency, thus avoiding the primary powertrain resonant frequency during operation. A CDA mode can be selected above the second engine speed limit to operate the machine above the primary powertrain resonant frequency.

Abstract: A live media streaming system and method is presented herein. The system and method includes broadcasting a live media stream in at least one of a plurality of themed broadcasting channels, the live media stream being transmitted from a broadcasting device corresponding to a broadcasting user. A jump zone (a physical region or area) is selected or defined based upon predetermined jump zone criteria corresponding to the at least one of the plurality of themed broadcasting channels. Further, a next broadcasting user is selected, wherein the user is located within the physical geographic region of the jump zone. Once the next broadcasting user is selected, a live media stream is broadcasted from the next user's broadcasting device.

Abstract: A method of forming a batch of porous catalytic carrier particles may include applying a precursor mixture into a shaping assembly within an application zone to form a batch of precursor porous catalytic carrier particles, drying the batch of precursor porous catalytic carrier particles within the shaping assembly to form the batch of porous catalytic carrier particles, and directing an ejection material at the shaping assembly under a predetermined force to remove the batch of porous catalytic carrier particles from the shaping assembly. The batch of porous catalytic carrier particles may have an average pore volume of at least about 0.1 cm3/g.