Abstract: The present invention relates to 39-desmethoxyrapamycin derivatives and their uses thereof. The present invention provides for the use of these compounds in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

Abstract: The present invention relates to 39-desmethoxyrapamycin derivatives and their uses thereof. The present invention provides for the use of these compounds in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

Abstract: The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

Abstract: The present invention relates to a vaccine for the treatment or prevention of an EBV-associated disease in a subject, wherein said vaccine comprises a synthetic polypeptide comprising a plurality of different segments of at least one parent EBV polypeptide, and wherein the segments are linked together in a different relationship relative to their linkage in the at least one parent EBV polypeptide.

Abstract: The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

Abstract: An anti-scaling device comprises a hollow central body for mounting on a bar and several spike units extending outwardly from the body in different directions. Pairs of spike units are rotatably and preferably detachably mounted on opposite sides of the central body. The device may further comprise serrated webs extending outwardly from the central body between the spike units. The device may also comprise rows of sharp-edged teeth axially aligned along the central body. Alternatively, the spike units may be partially rotatable serrated propellers or may be pivotably rotatably mounted. The device may be moulded from plastic material.

Abstract: An apparatus, kit and method are provided for a turkey call having an outer ring attached to a pot of a turkey call device such that an internal sounding board in the pot is free to vibrate and undampened by a user's grasp when a user scrapes the surface of the striking plate of the turkey call. The outer ring is attached to the pot by a connecting means. The striking plate is surrounded by the pot, which encloses the internal sounding board. The internal sounding board is mounted to the pot. The connecting means attaches the pot to the outer ring at a minimum number of points to leave the internal sounding board free to vibrate when the striker is used to scrape the surface of the striking plate of the turkey call.

Abstract: A magnetic plate retention system especially suitable for use in retaining a lithographic plate material to a conventional plate cylinder utilizes one or more magnetic retention devices each having a curved surface complementary to the cylinder. When disposed on the plate, the retention devices magnetically adhere the plate to the underlying cylinder.

Abstract: A sheet material holding device for receipt in a ring binder includes an elongated rectangular-shaped insert with a plurality of aligned apertures along one side. Each of the aligned apertures are positioned for registration with one of the rings of the binder. In each end of the insert is at least one slot wherein the slots are aligned to receive an endless elastomeric cord, or the like therein. A sheet of music or other sheet materials may be passed underneath the elastomeric cord and will be retained in place by the pressure of the elastomeric cord.

Abstract: The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. These epitopes are QVKWRMTTL, VFSDGRVAC, VPAPAGPIV, TYSAGIVQI, LLDFVRFMGV, QNGALAINTF, VSSDGRVAC, VSSEGRVAC, VSSDGRVPC, VSSDGLVAC, VSSDGQVAC, VSSDGRVVC, VPAPPVGPIV, VEITPYEPTG, VEITPYEPTW, VELTPYKPTW, RRIYDLIKL, RKIYDLIEL and PYLFWLAGI. The present invention further provides vaccines including one or more of these epitopes, optionally with additional epitopes.

Abstract: The present invention provides an isolated cytotoxic Epstein-Barr virus T-cell epitope having the amino acid sequence TYSAGIVQI (SEQ ID NO: 34) which can be formulated as a water-in-oil formulation, and vaccine compositions comprising said epitope, optionally with additional epitopes.

Abstract: The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. These epitopes are QVKWRMTTL, VFSDGRVAC, VPAPAGPIV, TYSAGIVQI, LLDFVRFMGV, QNGALAINTF, VSSDGRVAC, VSSEGRVAC, VSSDGRVPC, VSSDGLVAC, VSSDGQVAC, VSSDGRVVC, VPAPPVGPIV, VEITPYEPTG, VEITPYEPTW, VELTPYKPTW, RRIYDLIKL, RKIYDLIEL and PYLFWLAGI. The present invention further provides vaccines including one or more of these epitopes, optionally with additional epitopes.

Abstract: The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. These epitopes are QVKWRMTTL, VFSDGRVAC, VPAPAGPIV, TYSAGIVQI, LLDFVRFMGV, QNGALAINTF, VSSDGRVAC, VSSEGRVAC, VSSDGRVPC, VSSDGLVAC, VSSDGQ-VAC, VSSDGRVVC, VPAPPVGPIV, VEITPYEPIG, VEITPYEPTW, VELTPYKPTW, RRIYDLIKL, RKIYDLIEL and PYLFWLAGI. The present invention further provides vaccines including one or more of these epitopes, optionally with additional epitopes.

Abstract: The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. The epitopes are selected from the group consisting of QAKWRLQTL, RYSIFFDY, HLAAQGMAY, YPLHEQHGM, SVRDRLARL, AVLLHEESM, VSFIEFVGW, FRKAQIQGL, PYLFWLAAI, TVFYNIPPMPL, PGDQLPGFSDGRACPV, VEITPYKPTW, and variants thereof. In addition, the present invention provides compositions including these epitopes for use in inducing CTL's in a subject.

Abstract: A floating cradle assembly for an arm support system is provided with a yoke having cam surfaces and crank-controlled followers arranged to ride along the cam surfaces as the cradle moves vertically with respect to the yoke. As a result, the user of the arm support system experiences as uniform upward biasing force, and the yoke will not bind within the cradle housing. Different cam surface configurations will also result in different magnitudes of the uniform upward biasing force to accommodate the user's comfort.

Abstract: A device and method are shown for laminating a label on a surface of a moving article after first applying the label to the surface of the moving article. A pressure sensitive label is applied from a label dispenser to the receiving face of a vacuum box where it is releasably retained by reduced pressure within the box. A piece of transparent, pressure sensitive laminate material is similarly dispensed to the vacuum grid and retained in position by reduced gas pressure. As an article to be labeled is moved past the vacuum box, a blast of positive gas pressure is supplied through the vacuum grid and against the label to transfer the label to the surface of the article. As the article continues to move, a blast of positive gas pressure is supplied through the vacuum grid in the vacinity of the laminate material to remove the laminate material and transfer the material to the surface of the moving article to laminate the previously applied label.

Abstract: In a machine for reducing the cross-section of a number of wires by drawing each of them through a respective series of dies of decreasing diameter, a corresponding series of individual capstans is used for drawing each wire through its series of dies, and each one of several drive shafts supports at spaced positions along its length the capstans of a respective drawing stage of each series. Each capstan is driven by the shaft on which it is mounted, and the drive mechanism for the shafts can be adjusted, by presetting or otherwise, to give different peripheral speed ratios to the capstans, to suit different die sets and/or to compensate for wear. The capstans are mounted between bearings supporting the shafts, and the drive mechanism is located outside the bearing at the relevant end of the shaft. Preferably mechanism coupling adjacent shafts alternates between the two ends of the machine.

Abstract: A wire-drawing machine, suitable for use in-line with an enamelling machine, comprises a plurality of individual wire-drawing capstans mounted in individual bearings, at least one for each capstan. The capstans are arranged in a substantially planar rectangular array (comprising rows and columns of the capstans) with their axes aligned with the rows thereof. A series of parallel drive shafts, each serve all the capstans of one row or one column of the array. The capstans of one column are associated with a single wire line whereas the capstans of any one row are associated with a corresponding drawing stage for all the wires lines.