Abstract: Techniques to provide transaction redundancy in an IC include receiving an original memory access request directed to a first memory aperture, constructing a redundant memory access directed to a second memory aperture, and selectively returning a response of the first or second memory aperture to an originator based on contents of the responses. For a write operation, if acknowledgement indicators of the responses indicate success, a response is returned to the originator. For a read operation, if acknowledgement indicators of the responses indicate success and data returned in the response match one another, a response is returned to the originator. If the acknowledgement indicators indicate success, but the data does not match, a retry of the original and redundant read requests is initiated. If any of the acknowledgement indicators do not indicate success, an error is declared. In a mixed-criticality embodiment, the redundant memory access request may be constructed selectively.

Abstract: A system includes a lock and release connector, an implantable medical device, and an outer tube. The lock and release connector includes a connector body defining a recess extending to an axial end portion of the connector body. The implantable medical device has an extension receivable in the recess and extending through the axial end portion. The outer tube extends over the recess to retain the extension in the recess. The lock and release connector further includes a retention element receivable in the recess to secure the extension in the recess. When the outer tube is axially withdrawn from the recess, the retention element is movable from a retaining position to a releasing position to permit disengagement of the extension from the recess for deployment of the implantable medical device.

Abstract: A computing device for generating content includes one or more memories to store instructions and one or more processors to execute the instructions to perform operations, the operations including: providing, in response to a selection of a plurality of items of content, a user interface including a first portion and a second portion, the first portion including a summary description generated via one or more machine-learned models based on the plurality of items of content and the second portion including a plurality of user interface elements configured to perform an operation with respect to at least one of the summary description or the plurality of items of content.

Abstract: Screw inserter instruments and methods for implanting a bone screw are disclosed herein. In one exemplary embodiment, a screw inserter instrument can include a screw drive assembly having a first handle and a driver shaft coupled to the first handle, and a stylet assembly having a second handle and a stylet extending through the driver shaft. The first handle can have a locked configuration, in which the first handle and the driver shaft are coupled such that the first handle can maintain the driver shaft in a fixed position while the second handle is rotated relative to the first handle, and an unlocked configuration, in which the first handle and the driver shaft can rotate simultaneously in a first direction and the first handle can rotate independent of the driver shaft in a second opposite direction.

Abstract: In an embodiment, a system attaches a patient reference array of a computer-assisted surgery system to a patient. The system includes a fixation post having a shaft having proximal and distal ends that are offset from. A threaded fastener is coupled to the shaft at the distal end that rotates relative to the shaft so as to engage internal threads of a pedicle screw, thereby causing the distal end of the shaft to translate in the anchor seat and urge the pedicle screw to transition from an unlocked configuration to a locked configuration. The attachment assembly has an arm that supports the patient reference array, and a coupler supported by the arm. The coupler has a fixation body that defines a recess that receives at least a portion of the fixation post, and an actuator that secures the attachment assembly to the fixation post.

Abstract: This invention relates to methods for separating, isolating and/or enriching extracellular matrix bodies in a biological fluid. More particularly, this invention discloses methods for isolating and detecting extracellular matrix bodies from a biological sample as medical information and/or for use in diagnosis and prognosis of disease. The methods include immuno-affinity capture of extracellular matrix bodies.

Abstract: A medical device includes an incision device operably coupled to a distal end of an elongate catheter. The incision device includes an incision channel, and a retractable cutting apparatus disposed within the incision channel. The retractable cutting apparatus includes a first cutting apparatus link that is rotatably fixed proximate to a distal end of the incision channel and a second cutting apparatus link that is attached to the first link proximal end of the first cutting apparatus link. The first cutting apparatus preferably includes a first cutting surface proximate to the first link proximal end of the first cutting apparatus link and the second cutting apparatus link includes a second cutting surface. The retractable cutting apparatus also includes a guide member coupled to cause the retractable cutting apparatus to move between a retracted position and a deployed position.

Abstract: This invention relates to methods for separating, isolating and/or enriching extracellular matrix bodies in a biological fluid. More particularly, this invention discloses methods for isolating and detecting extracellular matrix bodies from a biological sample as medical information and/or for use in diagnosis, prognosis and monitoring disease.

Abstract: A system includes a lock and release connector, an implantable medical device, and an outer tube. The lock and release connector includes a connector body defining a recess having planar lateral head portions extending to and intersecting with a cylindrical surface of the connector body, and a longitudinal neck portion extending from the head portion. The implantable medical device has an extension including a neck portion receivable in the longitudinal neck portion of the recess and a head portion receivable in the lateral head portions of the recess. The outer tube extends over the recess to retain the extension in the recess.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: An apparatus configured to detect small particles of a substance suspended in a matrix using ultrasound, may include: a container device configured to receive a sample in an inner volume, including: a first ultrasonic transducer mechanically coupled to or disposed on a first exterior portion of the container device and oriented toward the inner volume, the first ultrasonic transducer may include: a first ultrasonic transmitter; and a first ultrasonic receiver; optionally a first receiver amplifier coupled to the first receiver; optionally the first transmitter amplifier coupled to the first transmitter amplifier; and either: a) a software defined radio (SDR), or b) a signal generator and an oscilloscope, where SDR or signal generator and oscilloscope are electronically coupled to the first ultrasonic transmitter and electronically coupled to the first ultrasonic receiver amplifier; and the electronic controller coupled to the SDR or the signal generator and the oscilloscope.

Abstract: A computer product and methodology is contemplated for adaptively serving hold content during an automated communication session. This includes training a machine learning model with a set of training data that includes a feature of hold duration times during historical automated communication sessions. In response to encountering a computer transaction request during a new automated communication session, a hold time duration is predicted for executing the computer transaction request based on obtaining an inference from the machine learning model. Whether to serve hold content in response to the computer transaction request is determined, based on a comparison of the predicted hold time duration to a predetermined threshold time interval.

Abstract: A computer product and methodology is contemplated for adaptively serving hold content during an automated communication session. This includes training a machine learning model with a set of training data that includes a feature of hold duration times during historical automated communication sessions. In response to encountering a computer transaction request during a new automated communication session, a hold time duration is predicted for executing the computer transaction request based on obtaining an inference from the machine learning model. Whether to serve hold content in response to the computer transaction request is determined, based on a comparison of the predicted hold time duration to a predetermined threshold time interval.

Abstract: An insertion catheter for a circulatory support catheter having a circulatory support device carried by an elongate flexible catheter shaft. The insertion catheter comprises a tubular body with a distal portion configured to axially movably receive the circulatory support device. A diameter of the distal portion is greater than a diameter of a mid portion of the tubular body. The insertion catheter may be inserted into an introducer sheath for delivery of the MCS device. A distal end of the insertion catheter may be located distally of a distal end of the introducer sheath and distally of the arterial bifurcation. The distal portion of the insertion catheter containing the MCS device may be located distally of the bifurcation, with a distal end of the MCS device slightly offset from the distal end of the tubular body.

Abstract: A tachometer system for high-torque rotor for a handheld or spindle-mounted pneumatic tool. There are three main components of the tachometer system. This first main component is a measuring module that includes a photodetector electrically coupled to a cable. The measuring module is fastened inside an air turbine motor assembly with a plurality of exhaust ports. The measuring module is sized to fit within an exhaust bore of the air turbine motor assembly. In one example, the measuring module includes a photodetector mounting plug for firmly holding the photodetector in the exhaust bore of the air turbine motor assembly. Another example of the measuring module includes a photodetector mounting plug for firmly holding the photodetector in the exhaust bore of the air turbine motor assembly.

Abstract: The present invention relates to a continuous process for the production of polyol modified polyalkenylene terephthalates and the application of such polyol modified polyalkylene therephtalate on wire enamels.

Abstract: A medical device for creating elongated incisions within a pericardium is provided. The medical device includes an incision device operably coupled to a distal end of a catheter. The incision device includes an incision channel defined along the incision device. The medical device further includes a retractable cutting apparatus disposed within the incision channel. The retractable cutting apparatus includes a blade structured to move between a retracted position and a deployed position. In an instance in which the blade is in the retracted position, the blade is disposed within the incision channel. In an instance in which the blade is in the deployed position, the blade at least partially protrudes from the incision channel. The medical device further includes a cutting apparatus actuation mechanism structured to move the blade between the retracted position and the deployed position within a human body.

Abstract: A tapered medical access sheath can comprise an access sheath hub and an access sheath shaft extending distally from the access sheath hub. The access sheath shaft can comprise a first delivery lumen extending from a proximal end of the access sheath shaft to a side opening on a distal portion of the access sheath shaft, the first delivery lumen having a width configured to slidably receive a distal portion of a medical device disposed around a guidewire. The access sheath shaft can comprise a tapered distal end portion disposed distally of the side opening. A recess can extend along a longitudinal dimension of the tapered distal end portion from a proximal end to a distal end of the tapered distal end portion. The recess can be in fluid communication with the first delivery lumen and have a width smaller than the diameter of the first delivery lumen.

Abstract: Embodiments herein describe partitioning hardware and software in a system on a chip (SoC) into a hierarchy. In one embodiment, the hierarchy includes three levels of hardware-software configurations, enabling security and/or safety isolation across those three levels. The levels can cover the processor subsystem with compute, memory, acceleration, and peripheral resources shared or divided across those three levels.

Abstract: Disclosed is a medical device comprising an incision assembly coupled to a catheter and an incision opening defined along the incision assembly. A retractable cutting apparatus is disposed within the incision opening and comprises a first incision member comprising at least one first cutting surface and defining a first member proximal end rotatably fixed proximate to a distal end of the incision opening and the at least one cutting surface is located on a bottom edge of the first incision member. A second incision member comprises at least one second cutting surface and defines a second member distal end attached to the first incision member at a connection point between a first member distal end and the first member proximal end of the first incision member, and wherein the at least one second cutting surface is located on a bottom edge of the second incision member.