Abstract: An electrical-discharge machining tool comprising a ground electrode, a moveable and activatable assistive electrode and a cutting electrode, a first conduit for supplying a dielectric and a second conduit for flushing dielectric material, wherein when used on a dielectric layer on a substrate the assistive electrode is activated and positioned substantially between the ground electrode and the cutting electrode.

Abstract: A wearable air purification system including a wearable support configured to be supported on or around a head region of a user; and an air delivery mask connected to the wearable support which is shaped to bound an air delivery region and to deliver a flow of air to the air delivery region. The air delivery mask includes an illumination source including one or more light emitting elements located along a longitudinal edge of the air delivery mask. The system or ‘air purifier’ is configured to direct light to the area occupied by the user's mouth when the air purifier is worn, as well as in some examples providing illumination to a mask or visor of the product itself. Examples herein are more visually appealing but the form of illumination means that the user's face is more visible to others which therefore reduces facial features being obscured.

Abstract: A wearable air purification system including a wearable support configured to be supported on a head of a user, and an air delivery mask which is shaped to bound, at least partially, an air delivery region and to deliver a flow of air to the air delivery region. The wearable support includes a left side support and a right side support which support the air delivery mask therebetween; and a left side motor and a right side motor configured to drive a respective left or right side air flow towards or away from the air delivery region, each of the left and right side motors being mounted within a respective left or right side motor housing on a respective one of the left and right side supports so that, when the wearable support is supported on the head in use, the motors sit rearward of or above the user's ears.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: A wearable air purification system or air purifier including a wearable support configured to be supported on a head region of a user and having a first end connected to a first audio earpiece and a second end connected to a second audio earpiece; an air delivery mask in the form of an elongated bar that includes first and second ends connected to the wearable support and which is shaped to bound an air delivery region and to deliver a flow of air to the air delivery region. The wearable support and the air delivery mask include a respective flexible region which allows both the wearable support and the air delivery mask to fold into a compact configuration.

Abstract: This invention relates to methods and compositions for detecting, identifying and treating glaucoma diseases. More particularly, this invention discloses compositions and methods for affecting intraocular pressure and increasing ocular outflows in glaucoma. Compositions and methods provided include purified and synthesized extracellular vesicle complexes from glaucoma ocular humor for use in methods and devices for detecting, characterizing and treating glaucoma diseases along with active agents. The presence of extracellular vesicle complexes in glaucoma can also be used as a biomarker.

Abstract: The present invention relates to a continuous process for the production of polyol modified polyalkenylene terephthalates and the application of such polyol modified polyalkylene therephtalate on wire enamels.

Abstract: A delivery system comprises a catheter configured to be delivered through a blood flow pathway of a heart and an implant configured to maintain an opening in a tissue wall to allow blood flow through the opening and into the blood flow pathway and be delivered via the catheter. The implant is at least partially composed of a flexible material to allow the implant to bend with the catheter.

Abstract: The present invention relates to a continuous process for the production of polyol modified polyalkenylene terephthalates and the application of such polyol modified polyalkylene therephtalate on wire enamels.

Abstract: This invention relates to methods and compositions for detecting, identifying and treating glaucoma diseases. More particularly, this invention discloses compositions and methods for affecting intraocular pressure and increasing ocular outflows in glaucoma. Compositions and methods provided include purified and synthesized extracellular vesicle complexes from glaucoma ocular humor for use in methods and devices for detecting, characterizing and treating glaucoma diseases along with active agents. The presence of extracellular vesicle complexes in glaucoma can also be used as a biomarker.

Abstract: Surgical instruments and methods for delivering bone anchor assemblies into bone are disclosed herein. Use of these anchors or instruments can eliminate one or more of the steps in a conventional bone anchor installation procedure, improving surgical efficiency and safety. In general, a surgical instrument can include a handle assembly having an elongate shaft extending distally therefrom. The handle assembly can be configured to axially translate a carrier assembly that secures a stylet extending therethrough. Translation of the stylet can be made relative to a distal end of the elongate shaft. The surgical instruments can include various carrier assemblies for positioning the distal end of the stylet relative to the distal end of the elongate shaft based on a length of bone anchor to be installed by the surgical instrument.

Abstract: A lock mechanism having a bolt movable between a thrown position and a retracted position, and a deadbolt assembly includes a sliding deadbolt configured to slide between a locked position in which the sliding deadbolt inhibits retraction of the bolt and an unlocked position. The sliding deadbolt includes a first anti-thrust cam configured to restrain the sliding deadbolt in the locked position, and a release driver arranged such that, when driven, the release driver releases the first anti-thrust cam from restraining the sliding deadbolt in the locked position and slides the deadbolt to the unlocked position.

Abstract: Embodiments herein describe partitioning hardware and software in a system on a chip (SoC) into a hierarchy. In one embodiment, the hierarchy includes three levels of hardware-software configurations, enabling security and/or safety isolation across those three levels. The levels can cover the processor subsystem with compute, memory, acceleration, and peripheral resources shared or divided across those three levels.

Abstract: Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.

Abstract: A medical implant comprises a central flow portion having a first network of struts forming two or more cells, a first set of anchoring arms, and a second set of anchoring arms. The two or more cells are arranged linearly and extend from the first set of anchoring arms to the second set of anchoring arms.

Abstract: This invention relates to methods and compositions for treating diseases of intraocular pressure. More particularly, this invention discloses a range of compounds, devices and methods for detecting and/or affecting intraocular pressure, treating glaucoma diseases, and increasing ocular outflows. Compositions of this disclosure can be used for reducing ocular extracellular complexes.

Abstract: Surgical instruments and methods for delivering bone anchor assemblies into bone are disclosed herein. Use of these anchors or instruments can eliminate one or more of the steps in a conventional bone anchor installation procedure, improving surgical efficiency and safety. In general, a surgical instrument can include a handle assembly having an elongate shaft extending distally therefrom. The handle assembly can be configured to axially translate a carrier assembly that secures a stylet extending therethrough. Translation of the stylet can be made relative to a distal end of the elongate shaft. The surgical instruments can include various carrier assemblies for positioning the distal end of the stylet relative to the distal end of the elongate shaft based on a length of bone anchor to be installed by the surgical instrument.

Abstract: Systems, methods, and devices for Bluetooth numeric comparison pairing between a handheld payment terminal and a base station that is incapable of displaying digits of a base station Bluetooth pairing code are disclosed. A handheld payment terminal computer program may initiate Bluetooth numeric pairing with a base station; generate a handheld payment terminal Bluetooth pairing code; capture a coded light sequence emitted by LEDs on the base station; decode the coded light sequence to determine the base station Bluetooth pairing code; cause the base station Bluetooth pairing code and the handheld payment terminal Bluetooth pairing code to be displayed on a display; and in response to Bluetooth pairing code match, pairing the handheld payment terminal with the base station. The base station provides access to one or more networks and/or data communication to the handheld payment terminal when paired.

Abstract: Embodiments herein describe memories in a processor system in an integrated circuit (IC) that can be assigned to either a cache coherent domain or an I/O domain, rather than being statically assigned by a designer of the IC. That is, the user or customer can assign the memories to domain that best suits their desires. Further, the memories can be reassigned to a different domain if the user later changes her mind.