Patents by Inventor James P. Beck

James P. Beck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocycles useful in the treatment of alzheimer's disease
    Patent number: 7442691
    Abstract: The present invention are macrocycles of the formula (IX): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: October 28, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink
  • 4-Phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
    Patent number: 7419985
    Abstract: Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: September 2, 2008
    Assignee: AMR Technology, Inc.
    Inventors: James P. Beck, Anthony D. Pechulis, Arthur E. Harms
  • 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
    Patent number: 7309789
    Abstract: Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: December 18, 2007
    Assignee: AMR Technology, Inc.
    Inventors: James P. Beck, Anthony D. Pechulis, Arthur E. Harms
  • Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof
    Patent number: 7265116
    Abstract: Provided herein are compounds of the formula (I): wherein R1-R8 are as described herein, R4 being phthalazinyl, pyrazinyl, pyridazinyl, or quinoxalinyl. Such compounds are particularly useful in the treatment of a disorder which is created by or is dependent upon decreased availability of serotonin, norepinephrine, or dopamine.
    Type: Grant
    Filed: August 13, 2004
    Date of Patent: September 4, 2007
    Assignee: ARM Technology, Inc.
    Inventors: James P. Beck, Matt A. Curry, Mark A. Smith
  • Hydroxypropyl amides for the treatment of Alzheimer's disease
    Patent number: 7262208
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: August 28, 2007
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: John A. Tucker, Brian A. Sherer, Ying Zi Xu, Louis Brogley, Shon R. Pulley, Jon S. Jacobs, James P. Beck, Varghese John
  • Acetyl 2-hydroxy-1, 3-diaminoalkanes
    Patent number: 7244725
    Abstract: Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and RC are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: July 17, 2007
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: Varghese John, Michel Maillard, James P. Beck, Eric T. Baldwin, Robert Hughes, Shon R. Pulley, Ruth TenBrink
  • Compounds to treat Alzheimer's disease
    Patent number: 7214715
    Abstract: The present invention is substituted amines of formula (X) and of the formula (X?) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: May 8, 2007
    Assignees: Pharmacia & Upjohn, Elan Pharmaceuticals
    Inventors: James P. Beck, Lawrence Y. Fang, John N. Freskos, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Varghese John, Michel Maillard, Shon R. Pulley, Ruth E. TenBrink
  • 4-phenyl substituted tetrahydroisoquinolines and use thereof
    Patent number: 7163949
    Abstract: Provided herein are compounds of the formulae IA–IF. These compounds are tetrahydroisoquinolines of the following structure: wherein R1–R8 for compounds of each of the formulae IA, IB, IC, ID, IE and IF are as described herein. Said compounds are particularly useful in the treatment of various neurological and psychiatric disorders, e.g., ADHD.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: January 16, 2007
    Assignee: AMR Technology, Inc.
    Inventors: James P. Beck, Mark A. Smith
  • 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
    Patent number: 7084152
    Abstract: Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 1, 2006
    Assignee: AMR Technology, Inc.
    Inventors: James P. Beck, Anthony D. Pechulis, Arthur E. Harms
  • Macrocycles useful in the treatment of Alzheimer's disease
    Patent number: 7067507
    Abstract: The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: June 27, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink, Jon S. Jacobs
  • Imidazopyrimidinyl and imidazopyri dinyl derivatives
    Patent number: 7045529
    Abstract: Provided herein are compounds of the formula (I): as well as stereoisomers and pharmaceutically acceptable salts thereof. Such compounds are, because of their ability to antagonize CRF, useful in the treatment of a variety of disorders characterized by execssive CRF expression. These include, for example: affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, gastrointestinal diseases, anorexia nervosa or other feeding disorder, drug addiction, drug or alcohol withdrawal symptoms, inflammatory diseases, cardiovascular or heart-related diseases, fertility problems, human immunodeficiency virus infections, hemorrhagic stress, obesity, infertility, head and spinal cord traumas, epilepsy, stroke, ulcers, amyotrophic lateral sclerosis and hypoglycemia.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: May 16, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Richard G. Wilde, Rajagopal Bakthavatchalam, James P. Beck, Argyrios Arvanitis
  • Macrocycles useful in the treatment of Alzheimer's disease
    Patent number: 6969709
    Abstract: The present invention are macrocycles of the formula (IX): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: November 29, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink
  • Compounds to treat alzheimer's disease
    Patent number: 6846813
    Abstract: The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: January 25, 2005
    Assignees: Pharmacia & Upjohn Company, Elan Pharmaceuticals, Inc.
    Inventors: James P. Beck, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Varghese John, Michel Maillard
  • Use of bicyclo compounds for treating alzheimer's disease
    Publication number: 20040254213
    Abstract: Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (I) wherein X, Y, Z, R1, R2, and R3 are defined herein.
    Type: Application
    Filed: July 23, 2004
    Publication date: December 16, 2004
    Inventor: James P. Beck
  • Use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence
    Publication number: 20040248932
    Abstract: Provided herein are methods of using compounds of formula (1) that are aryl- and heteroaryl-substituted tetrahydroisoquinolines, for the treatment of chronic and neuropathic pain, the treatment and prevention of migraine headache, and the treatment of stress, urge and mixed urinary incontinence.
    Type: Application
    Filed: December 1, 2003
    Publication date: December 9, 2004
    Inventors: Donald E. Frail, Stephen P. Arneric, Donn Gregory Wishka, Erik Ho Fong Wong, James P. Beck
  • Use of 4-phenyl substituted tetrahydroisoquinolines in the treatment of pain, migraine and urinary incontinence
    Publication number: 20040248925
    Abstract: Provided herein are methods of using compounds of formula (IA, IB, IIA, IIB, IIIA, IIIB) that are aryl- and heteroaryl-substituted tetrahydroisoquinolines, for the treatment of chronic and neuropathic pain, the treatment and prevention of migraine headache, and the treatment of stress, urge and mixed urinary incontinence.
    Type: Application
    Filed: December 1, 2003
    Publication date: December 9, 2004
    Inventors: Donald E. Frail, Stephen P. Arneric, Donn Gregory Wishka, Erik Ho Fong Wong, James P. Beck
  • Use of 4-phenyl-substituted tetrahydroisoquinolines in the treatment of pain, migraine headaches and urinary incontinence
    Publication number: 20040248933
    Abstract: Provided herein are methods of using compounds of formula (IA-IF) that are aryl- and heteroaryl-substituted tetrahydroisoquinolines, for the treatment of chronic and neuropathic pain, the treatment and prevention of migraine headache, and the treatment of stress, urge and mixed urinary incontinence.
    Type: Application
    Filed: December 1, 2003
    Publication date: December 9, 2004
    Inventors: Donald E. Frail, Stephen P. Arneric, Donn Gregory Wishka, Erik Ho Fong Wong, James P. Beck
  • Novel imidazopyrimidinyl and imidazopyri dinyl derivatives
    Publication number: 20040229887
    Abstract: Provided herein are compounds of the formula (I): 1
    Type: Application
    Filed: December 15, 2000
    Publication date: November 18, 2004
    Inventors: Richard G. Wilde, Rajagopal Bakthavatchalam, James P. Beck, Argyrios Arvanitis
  • Acetyl 2-hydroxy-1, 3-diaminoalkanes
    Publication number: 20040180939
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: September 10, 2003
    Publication date: September 16, 2004
    Inventors: Varghese John, Michel Maillard, James P. Beck, Eric T. Baldwin, Robert Hughes, Shon R. Pulley, Ruth TenBrink
  • Hydroxypropyl amides for the treatment of Alzheimer's disease
    Publication number: 20040039034
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: April 30, 2003
    Publication date: February 26, 2004
    Inventors: John A. Tucker, Brian A. Sherer, Ying Zi Xu, Louis Brogley, Shon R. Pulley, Jon S. Jacobs, James P. Beck, Varghese John