Abstract: The present invention are macrocycles of the formula (IX): 1

Abstract: The present invention is macrocycles of the formula (X): 1

Abstract: Provided herein are compounds of the formula (I): 1

Abstract: Provided herein are compounds of the formula (I): wherein R1-R8 are as described herein, R4 being aryl or heteroaryl Such compounds are particularly useful in the treatment of a disorder which is created by or is dependent upon decreased availability of serotonin, norepinephrine or dopamine.

Abstract: Corticotropin releasing factor (CRF) antagonists of Formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.

Abstract: The present invention is disubstituted amines of formula (I) 1

Abstract: Provided herein are compounds of the formula (I): 1

Abstract: The present invention is substituted amines of formula (X) 1

Abstract: Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.

Abstract: Corticotropin releasing factor (CRF) antagonists of Formula (I): 1

Abstract: Corticotropin releasing factor (CRF) antagonists of Formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.

Abstract: Corticotropin releasing factor (CRF) antagonists of Formulae (I) or (II): and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Abstract: Corticotropin releasing factor (CRF) antagonists of formula I: ##STR1## and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.

Abstract: A peristaltic pump having a plurality of removable cartridges, each containing a length of tubing, and each having means for adjusting occlusion comprising a linearly displaceable occlusion bed. Tubing retainers on each cartridge stabilize the tubing segments to constrain them against longitudinal displacement during pumping. Means are provided to enable visual determination of occlusion adjustment through the top of each cartridge. Each of the cartridges is reversible, and is readily installed on the pump frame and retained thereon by a snap-lock mechanism.

Abstract: A nonintrusive, or noncontact, shaft torquemeter for use in measuring torque transmission through a rotatable shaft. The torquemeter includes an annular torque-sensing coil structure having an annular excitation coil and a pickup coil magnetically coupled to the excitation coil through an improved magnetostrictive coupling structure carried by the shaft. In the illustrated embodiment, the magnetostrictive coupling portion is provided on a tube coaxially fixed at its ends to the shaft. The invention comprehends the provision of structure for preventing a continuous annular conductive path through the coupling portion or tube. Other structure for improving torque measuring accuracy may be provided, including the use of an outer magnetic stator core, and the provision of annular corrugations in the tube for preventing transmission of nontorque forces, such as bending forces, to the coupling portion.

Abstract: A substrate solution comprising (a) a substrate selected from a group consisting of salts of L-.gamma.-glutamyl-p-nitroanilide and L-.gamma.-glutamyl-3-carboxy-p-nitroanilide; and (b) a polyol selected from a group consisting of alkyl polyols containing 2 to 10 carbon atoms and 2 to 10 hydroxy groups and polyethylene glycol having an average molecular weight of from about 200 to about 600.Also, a kit for the determination of .gamma.-glutamyltransferase activity of the type comprising (a) a buffered medium comprising a buffer and a .gamma.-glutamyl residue acceptor; and (b) a substrate solution; the buffered medium and substrate solution being adapted such that preselected aliquots thereof can react in the presence of .gamma.-glutamyltransferase to produce an absorbing cleavage product. The kit is characterized in that the substrate solution is as described above.In addition, a method for determining .gamma.

Abstract: An improved method and apparatus is disclosed for producing frozen particulate compositions from liquid feedstock. A continuous stream of liquid feedstock is passed through an orifice and into a liquid freezant without the orifice contacting the freezant. Compositions produced by this improved method have low proportions of fine and large particles, yielding particularly beneficial results in the case of quality control materials. The compositions are advantageously employed in automated weighing and filling apparatus.

Abstract: A variable speed clutch drive for light vehicles, e.g. motor bikes, snowmobiles, etc., responds to both engine speed and torque. The drive includes a conical pulley system of driver and driven pulleys coupled by a continuous V-belt. The driven pulley includes torque responsive means which utilize fixed and movable discs, the fixed disc containing radially arcuate apertures circularly disposed about its center of rotation. The discs are biased together by a spring system which includes a spring cover containing at least one integral cam for sliding contact with at least one aperture in the fixed disc.

Abstract: An improved method and apparatus is disclosed for producing frozen particulate compositions from liquid feedstock. A continuous stream of liquid feedstock is passed through an orifice and into a liquid freezant without the orifice contacting the freezant. Compositions produced by this improved method have low proportions of fine and large particles, yielding particularly beneficial results in the case of quality control materials. The compositions are advantageously employed in automated weighing and filling apparatus.