Patents by Inventor James P. English

James P. English has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130023688
    Abstract: The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
    Type: Application
    Filed: July 24, 2012
    Publication date: January 24, 2013
    Applicant: Eisai Inc.
    Inventors: Keith Branham, Mahesh V. Chaubal, James P. English, Donna Hall, Zhong Zhao
  • Patent number: 8258255
    Abstract: The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: September 4, 2012
    Assignee: Eisai Inc.
    Inventors: Keith Branham, Mahesh V. Chaubal, James P. English, Donna Hall, Zhong Zhao
  • Publication number: 20100267924
    Abstract: The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
    Type: Application
    Filed: January 22, 2010
    Publication date: October 21, 2010
    Applicant: Eisai Inc.
    Inventors: Keith Branham, Mahesh V. Chaubal, James P. English, Donna Hall, Zhong Zhao
  • Patent number: 7674875
    Abstract: The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: March 9, 2010
    Assignee: Eisai Inc.
    Inventors: Keith Branham, Mahesh V. Chaubal, James P. English, Donna Hall, Zhong Zhao
  • Publication number: 20090247778
    Abstract: The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
    Type: Application
    Filed: January 16, 2009
    Publication date: October 1, 2009
    Applicant: Eisai Corporation of North America
    Inventors: Keith Branham, Mahesh V. Chaubal, James P. English, Donna Hall, Zhong Zhao
  • Patent number: 7479535
    Abstract: The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: January 20, 2009
    Assignee: Guilford Pharmaceuticals, Inc.
    Inventors: Keith Branham, Mahesh V. Chaubal, James P. English, Donna Hall, Zhong Zhao
  • Patent number: 6800672
    Abstract: Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: October 5, 2004
    Assignees: Guilford Pharmaceuticals, Inc., Johns Hopkins University School of Medicine
    Inventors: Wenbin Dang, Irina Kadiyala, Zhong Zhao, James P. English, Hai-quan Mao, Kam W. Leong
  • Patent number: 6600010
    Abstract: Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; R′ is an aliphatic, aromatic or heterocyclic residue; x is ≧1; and n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: July 29, 2003
    Assignees: Guilford Pharmaceuticals, Inc., John Hopkins University
    Inventors: Hai-Quan Mao, Kam W. Leong, Wenbin Dang, Hungnan Lo, Zhong Zhao, David P. Nowotnik, James P. English
  • Patent number: 6528080
    Abstract: A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: March 4, 2003
    Assignee: Atrix Laboratories, Inc.
    Inventors: Richard L Dunn, James P. English
  • Patent number: 6485737
    Abstract: A medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; R′ is an aliphatic, aromatic or heterocyclic residue; x is ≧1; and n is 3-7, 500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: November 26, 2002
    Assignee: Guilford Pharmaceuticals, Inc.
    Inventors: Hai-quan Mao, Kam W. Leong, Zhong Zhao, Wenbin Dang, James P. English, David P. Nowotnik
  • Publication number: 20020151617
    Abstract: Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: 1
    Type: Application
    Filed: January 15, 2002
    Publication date: October 17, 2002
    Inventors: Hai-Quan Mao, Kam W. Leong, Zhong Zhao, James P. English
  • Patent number: 6461631
    Abstract: A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.
    Type: Grant
    Filed: November 16, 1999
    Date of Patent: October 8, 2002
    Assignee: Atrix Laboratories, Inc.
    Inventors: Richard L Dunn, James P. English
  • Publication number: 20020137814
    Abstract: Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: 1
    Type: Application
    Filed: December 4, 2001
    Publication date: September 26, 2002
    Inventors: Wenbin Dang, Irina Kadiyala, Zhong Zhao, James P. English, Hai-Quan Mao, Kam W. Leong
  • Patent number: 6419709
    Abstract: An essentially non-osteoconductive medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; x is ≧1; and n is 3-7,500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: July 16, 2002
    Assignees: Guilford Pharmaceuticals, Inc., John Hopkins University School of Medicine
    Inventors: Hai-quan Mao, Kam W. Leong, Zhong Zhao, Wensin Dang, James P. English, David P. Nowotnik
  • Publication number: 20020091230
    Abstract: Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: 1
    Type: Application
    Filed: August 2, 2001
    Publication date: July 11, 2002
    Inventors: Hai-Quan Mao, Kam W. Leong, Wenbin Dang, Hungnan Lo, Zhong Zhao, David P. Nowotnik, James P. English
  • Publication number: 20020090398
    Abstract: A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.
    Type: Application
    Filed: January 14, 2002
    Publication date: July 11, 2002
    Applicant: Atrix Laboratories, Inc.
    Inventors: Richard L. Dunn, James P. English
  • Patent number: 6403675
    Abstract: Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: June 11, 2002
    Assignees: Guilford Pharmaceuticals, Inc., Johns Hopkins University
    Inventors: Wenbin Dang, Hai-quan Mao, Irina Kadiyala, Kam W. Leong, Zhong Zhao, James P. English
  • Patent number: 6376644
    Abstract: Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is —O— or —NR′—, where R′ is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M1 and M2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is —O—, —S— or —NR′—, where R′ is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: April 23, 2002
    Assignees: Guilford Pharmaceuticals, Inc., Johns Hopkins University School of Medicine
    Inventors: Hai-Quan Mao, Kam W. Leong, Zhong Zhao, James P. English
  • Patent number: 6352667
    Abstract: A method of making a biodegradable polymeric implant comprising the steps of aseptically mixing at least one monomer with at least one catalyst to form a polymerization mixture, injecting the polymerization mixture into a sterile mold, and polymerizing and/or cross-linking the polymerization mixture in the sterile mold to form a sterilized biodegradable polymeric implant. Additives may be included in the polymerization mixture as needed.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: March 5, 2002
    Assignee: Absorbable Polymer Technologies, Inc.
    Inventor: James P. English
  • Patent number: RE37950
    Abstract: A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: December 31, 2002
    Assignee: Atrix Laboratories
    Inventors: Richard L. Dunn, James P. English, Donald R. Cowsar, David P. Vanderbilt