Patents by Inventor James P. English
James P. English has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6352667Abstract: A method of making a biodegradable polymeric implant comprising the steps of aseptically mixing at least one monomer with at least one catalyst to form a polymerization mixture, injecting the polymerization mixture into a sterile mold, and polymerizing and/or cross-linking the polymerization mixture in the sterile mold to form a sterilized biodegradable polymeric implant. Additives may be included in the polymerization mixture as needed.Type: GrantFiled: August 24, 1999Date of Patent: March 5, 2002Assignee: Absorbable Polymer Technologies, Inc.Inventor: James P. English
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Patent number: 6322797Abstract: Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; R′ is an aliphatic, aromatic or heterocyclic residue; x is ≧1; and n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.Type: GrantFiled: April 2, 1998Date of Patent: November 27, 2001Assignees: Guilford Pharmaceuticals, Inc., Johns Hopkins UniversityInventors: Hai-Quan Mao, Kam W. Leong, Wenbin Dang, Hungnan Lo, Zhong Zhao, David P. Nowotnik, James P. English
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Patent number: 6166173Abstract: Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is --O-- or --NR'--, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M.sub.1 and M.sub.2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is --O--, --S-- or --NR'--, where R' is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat.Type: GrantFiled: April 2, 1998Date of Patent: December 26, 2000Assignees: Guilford Pharmaceuticals Inc., Johns Hopkins UniversityInventors: Hai-Quan Mao, Kam W. Leong, Zhong Zhao, James P. English
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Patent number: 6153212Abstract: A medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I below: ##STR1## wherein R is a divalent organic moiety; R' is an aliphatic, aromatic, or heterocyclic residue; x is .gtoreq.1; and n is 3-7,500, and where the biodegradable terephthalate copolymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. In addition, compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.Type: GrantFiled: October 2, 1998Date of Patent: November 28, 2000Assignees: Guilford Pharmaceuticals Inc., Johns Hopkins University School of MedicineInventors: Hai-quan Mao, Kam W. Leong, Zhong Zhao, Wenbin Dang, James P. English, David P. Nowotnik
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Patent number: 5990194Abstract: A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.Type: GrantFiled: November 7, 1997Date of Patent: November 23, 1999Assignee: Atrix Laboratories, Inc.Inventors: Richard L. Dunn, James P. English, Donald R. Cowsar, David P. Vanderbilt
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Patent number: 5739176Abstract: A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.Type: GrantFiled: March 18, 1994Date of Patent: April 14, 1998Assignee: Atrix Laboratories, Inc.Inventors: Richard L. Dunn, James P. English, Donald R. Cowsar, David D. Vanderbilt
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Patent number: 5733950Abstract: A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.Type: GrantFiled: September 25, 1995Date of Patent: March 31, 1998Assignee: Atrix Laboratories, IncorporatedInventors: Richard L. Dunn, James P. English, Donald R. Cowsar, David P. Vanderbilt
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Patent number: 5340849Abstract: A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.Type: GrantFiled: December 23, 1991Date of Patent: August 23, 1994Assignee: Atrix Laboratories, Inc.Inventors: Richard L. Dunn, James P. English, Donald R. Cowsar, David D. Vanderbilt
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Patent number: 5278201Abstract: A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.Type: GrantFiled: April 24, 1990Date of Patent: January 11, 1994Assignee: Atrix Laboratories, Inc.Inventors: Richard L. Dunn, James P. English, Donald R. Cowsar, David P. Vanderbilt
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Patent number: 5278202Abstract: A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.Type: GrantFiled: December 23, 1991Date of Patent: January 11, 1994Assignee: Atrix Laboratories, Inc.Inventors: Richard L. Dunn, James P. English, Donald R. Cowsar, David D. Vanderbilt
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Patent number: 5068220Abstract: Biodegradable polyamides, useful as absorbable sutures and as controlled release binder materials, are prepared by condensing 4,4'-spirobibutyrolactone with a primary diamine, optionally in the presence of a nylon salt, leading to homopolymers containing lactam structural units, or to random copolymers.Type: GrantFiled: June 8, 1990Date of Patent: November 26, 1991Assignee: Sharpoint L.P.Inventors: David P. Vanderbilt, Donald R. Cowsar, Richard L. Dunn, James P. English
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Patent number: 4950735Abstract: Biodegradable polyamides, useful as absorable sutures and as controlled release binder materials, are prepared by condensing 4,4'-spirobibutyrolactone with a primary diamine, optionally in the presence of a nylon salt, leading to homopolymers containing lactam structural units, or to random copolymers.Type: GrantFiled: July 26, 1988Date of Patent: August 21, 1990Assignee: Sharpoint L.P.Inventors: David P. Vanderbilt, Donald R. Cowsar, Richard L. Dunn, James P. English
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Patent number: 4938763Abstract: A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.Type: GrantFiled: October 3, 1988Date of Patent: July 3, 1990Inventors: Richard L. Dunn, James P. English, Donald R. Cowsar, David P. Vanderbilt
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Patent number: 4804691Abstract: A method for making an adhesive for use in joining soft living tissue including the steps of preparing a hydroxyl-terminated polyester by reacting a biodegradable monomer with a polyhydroxy polymerization initiator in the presence of an amount up to about 2.0 weight percent of a catalyst, and then preparing a diisocyanate-terminated prepolymer adhesive by reacting about 24 to 92 weight percent of the hydroxy-terminated polyester with about 8 to 76 weight percent excess aromatic diisocyante. The polyester and the diisocyanate are preferably dissolved in an organic solvent prior to the mixture thereof in a ratio of solids to solvent of about 60:40. The polyester is a polymer or copolymer of lactide, glycolide or .epsilon.-caprolactone. The initiator is ethylene glycol, diethylene glycol, pentaerythritol or 1,1,1-tris (hydroxymethyl) ethane. The catalyst is stannous octoate, a zinc compound, an aliphatic tertiary amine, dibutyltin diacetate or 1,4-diazabicyclo [2,2,2] octane.Type: GrantFiled: August 28, 1987Date of Patent: February 14, 1989Assignee: Richards Medical CompanyInventors: James P. English, Gerald W. McNeely, Richard L. Dunn