Abstract: A dental robot includes a platform and a suspension system. The suspension system supports the platform and automatically compensates for weights of the platform and a robot arm, end effector, and tooth clamp attached to the platform. The suspension system maintains a constant height of the platform above a base, absent an external force on the tooth clamp. The suspension system allows position and orientation of the platform to change, relative to the base, in response to an external force on the tooth clamp greater than about 0.1 N, such as a result of movement (change in position and/or orientation) of a subject. Consequently, the position and orientation of the platform remain fixed, relative to the subject's teeth, in response to movement of the teeth.

Abstract: Provided herein are intranasal fluid delivery devices and apparatus comprising a dispensing tip a shot chamber carrying a fluid, the shot chamber having a diaphragm at one end and a plunger at the other end, and an actuator connected to a push rod moveable toward the shot chamber.

Abstract: Disclosed herein, are compositions, methods, systems, and apparatus for collecting biological material from the nasal cavity of a subject or the olfactory region of a subject's nasal cavity. In some embodiments, the biological material is collected from a targeted sub-region of the nasal cavity, such as a targeted sub-region of the olfactory region, wherein such biological material is specific to the targeted sub-region. In some embodiments, the biological material collected from a targeted sub-region is preserved according to its localization. In some embodiments, the biological material comprises cerebrospinal fluid, one or more microbes of the patient's microbiome, one or more components of the patient's metabolome, one or more pathogens, and/or one or more biomarkers of interest. In some embodiments, a specific formulation is delivered to the region in the nasal cavity for facilitating biological material collection located therein.

Abstract: Provided herein are intranasal fluid delivery devices and apparatus comprising a dispensing tip a shot chamber carrying a fluid, the shot chamber having a diaphragm at one end and a plunger at the other end, an actuator connected to a push rod moveable toward the shot chamber, and a sheath covering at least a distal end of the dispensing tip, wherein the distal end of the dispensing tip is configured to extend from the sheath and into a subject's nasal cavity.

Abstract: A dental robot includes a platform and a suspension system. The suspension system supports the platform and automatically compensates for weights of the platform and a robot arm, end effector, and tooth clamp attached to the platform. The suspension system maintains a constant height of the platform above a base, absent an external force on the tooth clamp. The suspension system allows position and orientation of the platform to change, relative to the base, in response to an external force on the tooth clamp greater than about 0.1 N, such as a result of movement (change in position and/or orientation) of a subject. Consequently, the position and orientation of the platform remain fixed, relative to the subject's teeth, in response to movement of the teeth.

Abstract: Embodiments relate to an intranasal drug delivery device, system, and process. The drug delivery device can have a compliant/flexible soft nib. The drug delivery device can have an actuator and shot chamber. The drug delivery device can have a non-air interface mechanically pressurized fluid reservoir. The drug delivery device can have a facial or device recognition application to prevent intentional or unintentional misuse.

Abstract: Provided herein are intranasal fluid delivery devices and apparatus comprising a dispensing tip a shot chamber carrying a fluid, the shot chamber having a diaphragm at one end and a plunger at the other end, and an actuator connected to a push rod moveable toward the shot chamber.

Abstract: Embodiments relate to an intranasal drug delivery device, system, and process. The drug delivery device can have a compliant/flexible soft nib. The drug delivery device can have an actuator and shot chamber. The drug delivery device can have a non-air interface mechanically pressurized fluid reservoir. The drug delivery device can have a facial or device recognition application to prevent intentional or unintentional misuse.

Abstract: Disclosed herein, are compositions, methods, systems, and apparatus for collecting biological material from the nasal cavity of a subject or the olfactory region of a subject's nasal cavity. In some embodiments, the biological material is collected from a targeted sub-region of the nasal cavity, such as a targeted sub-region of the olfactory region, wherein such biological material is specific to the targeted sub-region. In some embodiments, the biological material collected from a targeted sub-region is preserved according to its localization. In some embodiments, the biological material comprises cerebrospinal fluid, one or more microbes of the patient's microbiome, one or more components of the patient's metabolome, one or more pathogens, and/or one or more biomarkers of interest. In some embodiments, a specific formulation is delivered to the region in the nasal cavity for facilitating biological material collection located therein.

Abstract: Embodiments relate to an intranasal drug delivery device, system, and process. The drug delivery device can have a compliant/flexible soft nib. The drug delivery device can have an actuator and shot chamber. The drug delivery device can have a non-air interface mechanically pressurized fluid reservoir. The drug delivery device can have a facial or device recognition application to prevent intentional or unintentional misuse.

Abstract: A method of producing a fluid absorbent web for the manufacture of disposable absorbent articles is provided, such as diapers, underpads, sanitary napkins or similar articles. The method includes the step of forming a uniform moving web of fiberized wood pulp having a central zone, applying hydrocolloid polymer particles onto the surface of the central zone, and distributing the applied particles into the body of the moving web by air pressure means. Apparatus for producing such articles is also provided featuring means for incorporating absorbent polymer particles within a central zone of a moving web of the matrix.