Abstract: A method includes identifying, by a processing device, a third-party service provider of a plurality of third-party service providers that is authorized by a user to access data associated with the user. A data privacy score is generated based on one or more privacy risk factors. The data privacy score is associated with the third-party service provider. The data privacy score is indicative of a level of protection and privacy the third-party service provider maintains with respect to the data. A user interface (UI) displaying at least the data privacy score associated with the third-party service provider is provided for presentation on a client device associated with the user.

Abstract: Systems and methods include a memory and processing devices configured to perform operations. The operations include obtaining telemetry log data comprising an event log that includes one or more values; parsing, using an event log parser extension, a first portion of the one or more values to insert one or more first key-value pairs into a data object, wherein at least a portion of the one or more first key-value pairs includes a value from the first portion of the one or more values and a key assigned to the value; and performing one or more data analysis operations on the data object.

Abstract: A method includes identifying, by a processing device, a data structure including cells to store data, wherein the cells are arranged within rows and columns of the initial data structure. A scrambled data structure is created in which at least a subset of cells of the initial data structure is rearranged such that each cell of the rearranged subset of cells is located in at least one of a different row or a different column of the initial data structure. Responsive to receiving a user request to access the data of the initial data structure, the processing device determines whether to provide the user with access to the initial data structure or the scrambled data structure.

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

Abstract: The present disclosure describes various improvements for programmable nuclease-based detection assays. Also provided are compositions, methods, kits, systems, and devices for practicing the same. Such improvements include improved reporter designs to facilitate the cleavage of a reporter immobilized on a substrate by an activated programmable nuclease. Improved reporter designs may comprise various lengths and structures of the reporter. The substrate can also comprise immobilized guide nucleic acids and/or programmable nucleases.

Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.

Abstract: The present invention provides 5-hydroxy-7-oxabicyclo[2.2.1]heptane-2-carboxamide derivatives of Formula (1) wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds. The compounds are used for inducing chondrogenesis, in methods of treating or preventing joint damage, resulting from joint injury or arthritis, and for inducing hyaline cartilage production. The present description discloses the preparation of exemplary compounds as well as pharmacological data thereof (examples 1 to 89; tables 1 and 2). An exemplary compound is e.g. rac-(1R,2R,3S,4R,5S)—N-(2-fluoro-5-(trifluoromethyl)phenyl)-5-hydroxy-3-(3-(trifluoromethyl)phenyl)-7-oxabicyclo[2.2.1]heptane-2-carboxamide (example 1).

Abstract: The invention relates to a microneedle array having a heat-generating element and its use for the intradermal application of active ingredients, particularly active pharmaceutical ingredients (API) and drugs, wherein this microneedle array is suitable for skin penetration on humans or animals and the microneedles consist of a water-soluble formulation, which contains at least one active ingredient.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

Abstract: A test assembly and method for performing a shock test of an article includes a pneumatic gun assembly, a Hopkinson bar assembly, a magnetic catch, and a support assembly. The support assembly suspends the article in alignment with the magnetic catch. The magnetic catch retains the article against the Hopkinson bar assembly. The pneumatic gun assembly includes a striker for propagating a shock through the Hopkinson bar assembly into the article.

Abstract: A computer program product, computerized method, and system for generating a Hybrid Non-Fungible Token and using a Hybrid Non-Fungible Token to confirm an identity during an electronic transaction. The Hybrid Non-Fungible Token containing Forensic Data which will include at least one of the following; unique biometric data, unique state issued identifying documents or specific unique machine attribute data tied to a specific computerized system. The plurality of authenticating servers further utilizing the Zero Knowledge Proofs to ensure that the servers in a group are authorized to have access to the Blockchain containing the Hybrid Non-Fungible Tokens. The invention further includes an Ethereum Blockchain distributed on the plurality of authenticating servers.

Abstract: Systems and methods include identifying fields associated with a log event of telemetry data and, for each field, selecting a key from multiple keys and generating a field-key mapping that includes a mapping from the fields to the selected key. The systems and methods generate an event log parser extension that includes the field-key mappings and validate the parser extension by testing its performance on sample log events. The systems and methods then execute a base parser and the validated event log parser extension on event logs to convert the event logs into a standardized format and perform data analytics on the standardized event logs to identify trends in the event logs and identify possible threats.

Abstract: The invention provides a system of mobile robotic devices configured to install the posts, racks, and photovoltaic (PV) panels of a solar farm. The invention also provides a computer command system (CCS) to direct the robotic devices for installation of the posts, racks, and panels with optimum speed and efficiency.

Abstract: Systems and methods for providing customized camera views of virtualized environments based on touch-based user inputs are provided herein. In one embodiment, a method includes providing a virtual gaming environment on a touch screen display device. The touch screen display device receives a touch-based user input comprising at least one swipe on the touch screen display device to create a customized camera viewing experience of a gameplay event of interest involving a target. During the traveling of a projectile, the touch-based user input is received on the touch screen display device. A customized camera view of the gameplay event of interest is provided based on the touch-based user input. A camera angle of the customized camera view is rotated, corresponding to a direction of the at least one swipe of the touch-based user input.

Abstract: An enhanced retractable flow discharge extension is configured for use in a coal pulverizer having a classifier system including a feedpipe to deliver from above raw coal to a pulverizing structure and a classifier cone positioned around the feedpipe to collect oversized coal for the pulverizing structure. The enhanced retractable flow discharge extension is configured to deliver oversized coal to the pulverizing structure and has a conical extension portion having an inlet end configured to be contiguous with the classifier cone outlet, a fixed cylindrical portion having an upper end contiguous with an outlet end of the conical extension portion, a movable cylindrical portion having a circumference larger than a circumference of the fixed cylindrical portion, the movable cylindrical portion being movably attached to the fixed cylindrical portion, and a distal portion movably attached to the movable cylindrical portion, the distal portion having a straight portion and a tapered portion.

Abstract: Compositions and methods for improved SNP discrimination are provided. An exemplary composition comprises a programmable nuclease and a non-naturally occurring guide nucleic acid that hybridizes to a target nucleic acid, or segment thereof, comprising at least one single-nucleotide polymorphism (SNP). Methods may comprise a) contacting the sample to: i) a detector nucleic acid and ii) the composition; and b) assaying for a signal indicative of cleavage of the detector nucleic acid by the first programmable nuclease. In an exemplary embodiment, the target nucleic acid is a coronavirus target nucleic acid.

Abstract: A flap-folding module for a food processing line is arranged to receive a food product lying on a sheet of material and to fold a portion of the sheet over the food product. A conveyor system carries the food product and sheet along a product flow path through the module. A gas jet outlet device provides a pulse of gas to raise a leading edge of the sheet, and an edge catch device receives the leading edge, temporarily retaining the leading edge whilst the food product passes beneath, thereby folding a leading portion of the sheet over at least part of the food product. The conveyor system comprises a mid-conveyor section and an upstream conveyor section which is upstream of the mid-conveyor section, and the upstream conveyor section is pivotable relative to the mid-conveyor section about a pivot axis which extends transversely across the product flow path.

Abstract: Various compositions and diagnostic devices for the detection of nucleic acids are provided. Also provided are systems comprising the same, and methods of using the same. In some embodiments, compositions and devices comprise or are configured to be used in combination with one or more of a guide nucleic acid, a programmable nuclease, and reporters. In some embodiments, presence of at least one sequence of interest is determined by detecting a signal produced upon cleavage of the reporters.

Abstract: Methods and apparatus for lightning strike protection are disclosed. A disclosed example apparatus includes a frame supporting an exterior panel, the exterior panel having a first side that at least partially defines an exterior surface of a vehicle, a shield panel placed at a second side of the exterior panel opposite the first side, and a spring extending from the frame at a first portion of the spring, a second portion of the spring being at least one of ramped or curved, the second portion contacting the shield panel to define an electrical coupling between the shield panel and an electrically conductive portion associated with the frame.

Abstract: The present invention relates to a vaccine composition comprising an influenza Type A hemagglutinin stabilized stem nanoparticle (HA-ss-np); an aluminum hydroxide; a synthetic oligodeoxynucleotide adjuvant containing at least one CpG motif (CpG ODN); and a phosphate salt, wherein the HA-ss-np is not substantially adsorbed to the aluminum hydroxide, and wherein at least a portion of the CpG ODN is adsorbed to the aluminum hydroxide in the composition. The present disclosure also provides a method of inducing an immunological response against an influenza virus in a subject in need thereof, comprising administering an immunologically effective amount of the vaccine composition described herein.