Abstract: A gambrel includes a frame including a fulcrum attachment. A first hanger is on a first lateral side of the frame. A second hanger is on a second lateral side of the frame. At least one line retainer is fixed relative to the frame.

Abstract: A biofilter irrigation system comprises a cylindrical vessel having a central axis, a media bed positioned within the vessel, a spray head system positioned above the media bed, the spray head system comprising a central hub positioned at the central axis of the vessel, at least one arm extending distally from the central hub toward a wall of the vessel and configured to rotate about the central axis, and a plurality of nozzles connected to the at least one arm. The biofilter irrigation system further comprises a fluid outlet positioned below the media bed.

Abstract: A gambrel includes a frame including a fulcrum attachment. A first hanger is on a first lateral side of the frame. A second hanger is on a second lateral side of the frame. At least one line retainer is fixed relative to the frame.

Abstract: A lateral semiconductor controlled rectifier (SCR) includes a pwell and an nwell A plurality of p+ contact regions connect to the pwell and are spaced apart from one another by a dielectric material along a width of the pwell. There are a plurality of n+ contact regions connect to the nwell and are spaced apart from one another by dielectric material along a width of the nwell.

Abstract: An electrostatic discharge protection system with a node adapted to receive a signal and threshold detecting circuitry coupled to the node. The system includes an IGBT having an IGBT gate coupled to an output of the threshold detecting circuitry, a resistor coupled between an IGBT emitter of the IGBT and a low reference potential node, and a BJT having a BJT base coupled to the IGBT emitter.

Abstract: An ESD protection system including structure to operate an IC during nominal conditions, to protect the IC during an ESD event, and to allow the IC to operate during slow rising input node voltages that exceed nominal conditions.

Abstract: A physical unclonable function is disclosed. A highly random distribution of magnetic particles within a thermoplastic polymer is created by magnetizing magnetizable particles in solid pellet feed material before feeding the solid pellets into an injection molding machine. Other devices and processes are disclosed.

Abstract: A physical unclonable function is disclosed. A highly random distribution of magnetic particles within a thermoplastic polymer is created by magnetizing magnetizable particles in solid pellet feed material before feeding the solid pellets into an injection molding machine. Other devices and processes are disclosed.

Abstract: An aircraft propulsion system comprising a reciprocating liquid cooled engine housed within the fuselage driving twin fuselage mounted ducted-fans is disclosed. The propulsion system may be liquid cooled with a liquid cooled exhaust and at least one turbocharger. The ducted-fans may run fan blade tip speeds of up to 97% Mach driven by a near constant RPM engine through a continuously variable transmission. The propulsion system may be low noise and may meet environmental standards typical in the automotive industry.

Abstract: A cosmetic or personal care formulation includes a carrier and porous metal oxide spheres wherein, the porous metal oxide spheres have, e.g., an average diameter of about 0.5 ?m to about 100 ?m and an average porosity of about 0.10 to about 0.80; the porous metal oxide spheres have one or more population of pores each having an average pore diameter, wherein each population has a different average pore diameter and wherein the average pore diameters are, e.g., from about 50 nm to about 999 nm.

Abstract: The invention relates to a microneedle array having a heat-generating element and its use for the intradermal application of active ingredients, particularly active pharmaceutical ingredients (API) and drugs, wherein this microneedle array is suitable for skin penetration on humans or animals and the microneedles consist of a water-soluble formulation, which contains at least one active ingredient.

Abstract: Described herein are methods to detect nucleic acid modifications, such as methylated DNA or methylated RNA, using a programmable nuclease. The present disclosure further provides compositions and methods for generating and amplifying ssDNA from target nucleic acid sequences, or templates, for activation of programmable nucleases. Further provided herein are methods of coupling ssDNA amplification and activation of programmable nucleases with programmable nuclease systems, such as DETECTR systems, including trans cleavage of detector nucleic acids to produce a signal indicating the presence of the target nucleic acid sequence.

Abstract: The present invention generally relates to a microjet array for use as a thermal management system for a heat generating device, such as an RF device. The microjet array is formed in a jet plate, which is attached directly to the substrate containing the heat generating device. Additional enhancing features are used to further improve the heat transfer coefficient above that inherently achieved by the array. Some of these enhancements may also have other functions, such as adding mechanical structure, electrical connectivity or pathways for waveguides. This technology enables higher duty cycles, higher power levels, increased component lifetime, and/or improved SWaP for RF devices operating in airborne, naval (surface and undersea), ground, and space environments. This technology serves as a replacement for existing RF device thermal management solutions, such as high-SWaP finned heat sinks and cold plates.

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Abstract: Disclosed herein are compositions, kits, and methods related to improved Cas activity. Through compositions and kits disclosed herein and practice of methods disclosed herein, one attains improved Cas activity such as Cas12 activity relative to Cas proteins in the art such as LbCas12. Further described herein are methods to detect target nucleic acid using a programmable nuclease system. Often, the target nucleic acids are present in at low frequency in the sample. Provided herein are methods for enriching these target nucleic acids for detection. Also described herein are methods to insert a PAM sequence into a target sequence of interest for use in a detection comprising a programmable nuclease.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: Concepts and technologies are disclosed herein for connection management service. A server computer can detect a request to create a connection between a first resource and a second resource. The first resource can be in a proximity of a computing device and the second resource may not be in a proximity of the computing device. The request can be triggered by a requestor. Authentication of the requestor can be triggered, and identification of the first resource can be obtained. The identification of the first resource can be obtained from the computing device. Connection information for the connection between the first resource and the second resource can be obtained and creation of the connection using the connection information can be triggered.