Abstract: Locking hinge apparatus for aircraft doors are disclosed. An example locking hinge apparatus includes a hinge base to couple to a frame of an aircraft. A hinge gooseneck is to pivotally couple a door to the hinge base. The hinge gooseneck is to allow the door to move between a closed position and an open position relative to the frame. A lever is pivotally coupled to the hinge base. The lever is to pivot relative to the hinge base between a first rotational direction and a second rotational direction opposite the first rotational direction. The lever includes a lock to engage a portion of the hinge gooseneck to prevent rotational movement of the door relative to the frame when the door is in the open position. A biasing element is to urge the lever in the first rotational direction.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: The present invention provides 5-hydroxy-7-oxabicyclo[2.2.1]heptane-2-carboxamide derivatives of Formula (1) wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds. The compounds are used for inducing chondrogenesis, in methods of treating or preventing joint damage, resulting from joint injury or arthritis, and for inducing hyaline cartilage production. The present description discloses the preparation of exemplary compounds as well as pharmacological data thereof (examples 1 to 89; tables 1 and 2). An exemplary compound is e.g. rac-(1R,2R,3S,4R,5S)-N-(2-fluoro-5-(trifluoromethyl)phenyl)-5-hydroxy-3-(3-(trifluoromethyl)phenyl)-7-oxabicyclo[2.2.1]heptane-2-carboxamid (example 1).

Abstract: The present invention provides 6-hydroxy-8-oxatricyclo[3.2.1.02,4]octane-2-carboxamide derivatives of Formula (1) wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds. The compounds are used for inducing chondrogenesis, in methods of treating or preventing joint damage, resulting from joint injury or arthritis, and for inducing hyaline cartilage production. The present description discloses the preparation of exemplary compounds as well as pharmacological data thereof (examples 1 to 82; tables 1 and 2). An exemplary compound is e.g. rac-(1R,2R,4S,5R,6S)-4-(2-fluoropyridin-4-yl)-6-hydroxy-N-(4-(trifluoromethyl)pyridin-2-yl)-8-oxatricyclo[3.2.1.02,4]octane-2-carboxamide (example 1).

Abstract: A device includes a processor. The processor is configured to execute instructions to receive first operator input and generate layers for a map based on the first operator input. The layers include features to indicate whether an Uncrewed Aerial Vehicle (UAV) operator should or could fly a UAV in an airspace corresponding to an area within the map. The processor is also configured to receive second operator input that specifies a path on the map, for a UAV flight.

Abstract: A galley for an aircraft includes a frame having metal structural members having interior surfaces and panels coupled to and supported by the frame. Each panel has a core and a facesheet having an inner surface. The frame and the panels define a cart compartment configured to receive a galley cart. The interior surfaces of the metal structural members are interior of the inner surface of the corresponding facesheet. The galley includes a cooling system having a supply duct and a return duct along one or more of the panels in flow communication with the cart compartment configured to supply cooled airflow from a heat exchanger. The galley includes insulating panels located in the cart compartment covering the interior surfaces of the corresponding metal structural members.

Abstract: A networked system of connected and trackable document deposit and destruction kiosks can be used to remotely dispose of and destroy confidential documents and monitors and records compliance with employer document destruction policies. A networked system of connected ballot deposit kiosks can be used to safely deposit, track, and verify the locations of completed ballots and to monitor and track the subsequent collection of the ballots by election officials or other authorized persons.

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A spectrometer for detecting one or more wavelength components of sample radiation is disclosed. The spectrometer includes: a detector comprising a two-dimensional rectilinear array of pixels for generating signals representing an image based on collected sample radiation; one or more optical components arranged to form a spatial pattern based on spectral features of the sample radiation the spatial pattern including a plurality of aligned substantially parallel fringes oriented at a non-zero skew angle to the two-dimensional rectilinear array; and an analyser arranged to receive the signals and provide an output related to the one or more wavelengths. The spectrometer suppresses column/row noise in the detector. Also disclosed is a method of suppressing noise when signals are extracted and processed from detector arrays.

Abstract: Concepts and technologies are disclosed herein for connection management service. A server computer can detect a request to create a connection between a first resource and a second resource. The first resource can be in a proximity of a computing device and the second resource may not be in a proximity of the computing device. The request can be triggered by a requestor. Authentication of the requestor can be triggered, and identification of the first resource can be obtained. The identification of the first resource can be obtained from the computing device. Connection information for the connection between the first resource and the second resource can be obtained and creation of the connection using the connection information can be triggered.

Abstract: Disclosed herein are compositions, kits, and methods related to improved Cas activity. Through compositions and kits disclosed herein and practice of methods disclosed herein, one attains improved Cas activity such as Cas12 activity relative to Cas proteins in the art such as LbCas12. Further described herein are methods to detect target nucleic acid using a programmable nuclease system. Often, the target nucleic acids are present in at low frequency in the sample. Provided herein are methods for enriching these target nucleic acids for detection. Also described herein are methods to insert a PAM sequence into a target sequence of interest for use in a detection comprising a programmable nuclease.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

Abstract: A method for manufacturing a rotor blade root assembly includes placing outer skin layer(s) onto a blade mold and arranging a root plate with a plurality of through holes adjacent to an end face of the blade mold. The method also includes placing a plurality of root inserts atop the outer skin layer(s) and abutting against the root plate, with each of the root inserts defining a fastener hole. The method also includes inserting a root fastener into each of the aligned through holes and longitudinal fastener holes. Moreover, the method includes placing inner skin layer(s) atop the root inserts. Further, the root plate may include at least one fluid hole configured therethrough to provide a non-gas tight root plate. Alternatively, at least one seal may be arranged between the root plate and the blade mold that forms a non-gas tight connection with either or both of the root plate or the blade mold during a vacuum infusion process.

Abstract: Methods and systems for improving the performance and functioning of a network and its components may include configuring an edge computing device to activate a long range (LoRa) Wide Area Network (WAN) gateway bridge as a container in a container platform operating on the edge computing device. The edge computing device may use the LoRa WAN gateway bridge to form a local private cloud network and communicate with LoRa end devices.

Abstract: Utensil dispensers and methods for making and using same. The utensil dispensers can include a housing configured to contain a stack of utensils. The stack of the utensils comprises at least one utensil in addition to a next utensil. At least one generally vertical guide rail can be disposed within the housing, and can be configured to receive a first portion of each utensil having a contoured projection extending outwardly from each utensil to maintain the stack of the utensils in a stacked orientation. A front pedestal can be disposed inside the housing and beneath the generally vertical guide rail. The front pedestal can be configured to contact the first portion of the next utensil, and a rear pedestal can be disposed inside the housing and beneath the generally vertical guide rail. The rear pedestal can be configured to contact a second portion of the next utensil.

Abstract: Systems and methods for providing customized camera views of virtualized environments are provided herein. In one embodiment a method includes detecting a gameplay event of interest within a virtual gaming environment and displaying a customized camera view of the gameplay event of interest based on user input receiving during traversal of a projectile from a weapon to a target. The customized camera view has a focal point of the projectile.

Abstract: The invention integrates emerging applications, tools and techniques for machine learning in medicine with videoconference networking technology in novel business methods that support rapid adaptive learning for medical minds and machines. These methods can leverage domain knowledge and clinical expertise with networked cognitive collaboration, augmented clinical intelligence and cybernetic workflow streams for learning health care systems. The invention enables multimodal clinical communications, collaboration, consultation and instruction between and among heterogeneous networked teams of persons, machines, devices, neural networks, robots and algorithms.

Abstract: In one embodiment, a method includes receiving, by a controller, one or more signals from the one or more pressure transducers. The one or more pressure transducers are coupled to one or more pressure lines, the one or more pressure lines are coupled to one or more probes, and the one or more probes coupled to a vehicle. The method also includes converting, by the controller, the one or more signals to one or more digital signals. The method further includes calculating, by the controller, a wind velocity relative to the vehicle using the one or more digital signals.

Abstract: A battery powered wireless apparatus, method, and system. A battery powered wireless node operates to communicating with a gateway on a local area network through the network communication device, cease communication with the gateway after a predetermined period for a predetermined interval of time, and communicate with the gateway continuously when an event occurs.