Abstract: The present disclosure relates to methods for determining the presence of or the amount of an analyte in a sample and to a slide for use in the method.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: An electro-mechanical device is disclosed. The electro-mechanical device has an electrical switch and a mechanical meter operably connected to the electrical switch. The mechanical meter includes at least one aperture. The mechanical meter includes at least one movable member having at least one of a plurality of barcodes or a plurality of characters. The at least one of the plurality of barcodes or the plurality of characters is selectively visible through the at least one aperture.

Abstract: A method and a wireless device for exchanging messages with an access point (AP) while the wireless device is in a pre-associated state during which the wireless device is unauthenticated and is not associated with a network. The wireless device receives a beacon from the AP indicating that the AP will protect messages communicated with the wireless device. The wireless device then sends to the AP a message including a request for information from the AP. The wireless device obtains a public key of the AP, and receives an encrypted response to the request and an encrypted symmetric key. The wireless device decrypts the encrypted symmetric key using the public key of the AP to recover a symmetric key that is not encrypted, and decrypts the encrypted response to the request using the decrypted symmetric key to recover a response to the request that is not encrypted.

Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: A computer readable media, a method, and a system registering a third party application providing an available communication system between a local user and a remote user identity, storing information related to the available communication system in a first database, obtaining contact information for the remote user identity from the third party application, determining a communication type for the third party application, pairing the remote user identity with a contact, and updating a graphical representation of contact information.

Abstract: Phosphor materials and devices containing such phosphor materials are disclosed. An ink composition of in accordance with the present disclosure comprises a phosphor material comprising a Mn4+ doped phosphor of formula 1, Ax[MFy]:Mn4+ (I), and at least one rare earth containing Garnet phosphor, the at least one rare earth Garnet phosphor is present in the phosphor material in an amount of at least about 80 wt % based on the weight of the phosphor material, wherein the at least one rare earth containing a Garnet phosphor has a D50 particle size from about 0.5 microns to about 15 microns, where A is Li, Na, K, Rb, Cs, or a combination thereof; M is Si, Ge, Sn, Ti, Zr, Al, Ga, In, Sc, Y, La, Nb, Ta, Bi, Gd, or a combination thereof; x is the absolute value of the charge of the [MFy] ion; and y is 5, 6 or 7.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: There is provided a downhole sucker rod pump comprising: a plunger, a housing including an inner surface, a housing passage defined by the inner surface, and a recess defined within the inner surface of the housing. The plunger and the housing are co-operatively configured such that the plunger is operable for reciprocating movement through the housing passage, with effect that: the plunger traverses a plunger-traversable section of the inner surface of the housing, and solids-comprising reservoir fluid material is displaceable in an uphole direction via the housing passage. At least a portion of the recess is a plunger-traversable recess, and the plunger-traversable recess portion is defined within the plunger-traversable section, the housing passage includes a downhole space disposed downhole relative to the plunger-traversable section, and the plunger-traversable recess portion is disposed in flow communication with the downhole space.

Abstract: A pixelated X-ray conversion screen includes a metal aperture sheet having a pixel hole filled with a scintillator material, wherein an area of the pixel hole is equal to or less than about 0.25 mm2.

Abstract: Using a graphical user interface (GUI), a user is guided to generate a logical graph that represents how real data is generated in a situation. The situation is simulated using an artificial intelligence (AI) model a number of times by having the AI model choose paths through the logical graph to generate synthetic data that is representative of the real data. The AI model may also use a reward table that the user is guided to generate via the GUI to execute the simulation, wherein the reward table incentivizes certain paths of the logical graph, and agents of the AI model are trained using the values of this reward table. This synthetic data generated via the AI model can be used for training other AI models.

Abstract: A table with a molded plastic body and a molded plastic plug fitted in a large round bottom opening in the body. A sealed internal body volume accommodates ballast. An internal hollow sleeve extends from an opening in the top of the body two a hollow core in the plug. An upper and lower corrugated gripping elements in the hollow sleeve and in the hollow core of the plug grip the pole of an umbrella. The round plug retained in the large round bottom opening by spin welding the round plug within the large round bottom opening.

Abstract: In some examples, a wireless device includes a communication interface to communicate with a wireless network, and at least one processor configured to, receive, from an access point (AP), information including a network address policy of the wireless network. The at least one processor is configured to further, in response to the information including the network address policy, use an address of the wireless device according to the network address policy.

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to bone morphogenetic protein-9 (BMP9) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

Abstract: In some examples, a system includes a plurality of network controllers, a WI-FI wireless local area network (WLAN) over which at least a first network controller and a second network controller of the plurality of network controllers are to communicate, wherein a link between the first network controller and the second network controller through the WI-FI WLAN is a synchronized link.

Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material in a consumable is disclosed. The non-combustible aerosol provision device includes a retention apparatus configured to hold in position, one at a time, each of the plurality of consumables comprising aerosol-generating material of different sizes.

Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: Derivatized malachite green leuco dyes for use in radio-chromic systems are described. The dyes have the following structure: in which Ar is a substituted phenyl or thiophene ring in which at least one substitution of the Ar ring is not ortho to the bond between the ring and the linking carbon, and in which R1, R2, R3, and R4 are independently selected from methyl, alkyl, or alkyl halide. The systems include the dyes in conjunction with an activator, e.g., a halogenated activator, and a carrier, e.g., a fluid carrier or an encapsulating polymeric matrix.