Abstract: Described are methods of prepraing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly usefull for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising tianeptine, kava, and optionally, at least one of CDP Choline, and Alpha GPC; and providing the composition of matter in a liquid or solid form. The ingredient of tianeptine can be tianeptine sodium, tianeptine free acid, or both. Providing the composition of matter can include filling a container with the composition of matter.

Abstract: A scalable RAID storage controller device system includes a host system coupled to a switch device by first and second NTB subsystems, first and second RAID storage devices connected to the switch device and provided in respective data storage device chassis having a storage device form factor, and first and second RAID storage controller devices connected to the switch device and provided in respective storage controller device chassis having the storage device form factor. The first RAID storage controller device executes commands received via the first NTB subsystem from the host system for a first RAID data storage system that it provides with the first RAID data storage system, and the second RAID storage controller device executes commands received via the second NTB subsystem from the host system for a second RAID data storage system that it provides with the second RAID data storage system.

Abstract: An autonomous RAID data storage system includes a RAID storage controller device that communicates with RAID data storage devices in order to configure them to perform direct command operations with each other. A first RAID data storage device receives a multi-step command from the RAID storage controller device and performs a first subset of operations associated with the multi-step command, while also performing direct command operations with a second RAID data storage device in order to cause it to perform a second subset of operations associated with the multi-step command, When the first RAID data storage device completes the first subset of operations and receives a first completion communication from the second RAID data storage device that indicates that the second subset of operations are completed, it sends a second completion communication to the RAID storage controller device that indicates that the multi-step command is completed.

Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising tianeptine, sakae naa, and optionally, at least one of kava, CDP Choline, and Alpha GPC; and providing the composition of matter in a liquid or solid form. The ingredient of tianeptine can be tianeptine sodium, tianeptine free acid, or both. Providing the composition of matter can include filling a container with the composition of matter.

Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising tianeptine, kava, and optionally, at least one of CDP Choline, and Alpha GPC; and providing the composition of matter in a liquid or solid form. The ingredient of tianeptine can be tianeptine sodium, tianeptine free acid, or both. Providing the composition of matter can include filling a container with the composition of matter.

Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising sakae naa and CDP; and providing the composition of matter in a liquid or solid form. Providing the composition of matter can include filling a container with the composition of matter.

Abstract: A RAID storage-device-assisted RMW system includes a RAID primary data drive that retrieves second primary data via a DMA operation from a host system, and XOR's it with its first primary data to produce first interim parity data that it writes via a DMA operation to a RAID parity data drive. The RAID parity data drive XOR's its first parity data and the first interim parity data to produce second parity data that overwrites the first parity data. The RAID parity data drive also performs GF operations on the first interim parity data and its second interim parity data and XOR's the results to produce interim Q data that it writes via a DMA operation to a RAID Q data drive. The RAID Q data drive XOR's its first Q data and the interim Q data to produce second Q data that overwrites the first Q data.

Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising sakae naa and kava; and providing the composition of matter in a liquid or solid form. Providing the composition of matter can include filling a container with the composition of matter.

Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising sakae naa and GPC; and providing the composition of matter in a liquid or solid form. Providing the composition of matter can include filling a container with the composition of matter.

Abstract: An implant assembly for a long bone is adapted to support an exo-prosthesis. The assembly includes a stem, a subdermal component and a percutaneous post. The stem has a proximal end that is adapted to be received in a surgically prepared medullary canal of the long bone, and a distal end having a surface that is adapted to promote bone ingrowth. The subdermal component includes a proximal portion that is adapted for attachment to the distal end of the stem, and a fixation surface that is adapted to promote soft tissue fixation. The percutaneous post has a proximal end that is adapted to be attached to the subdermal component.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: A non-rigid, soft, portable and foldable baby changing mat (1) having a restraint system (18) for restraining movement of a baby (46) during nappy changing or dressing in which the restraint system (18) comprises a knee controllable restraint system (18).

Abstract: An autonomous RAID data storage device locking system includes first RAID data storage device(s) that store data included in a data stripe, and that are coupled to a second RAID data storage device. The second RAID data storage device receives a command to perform a data update operation on a subset of data included in the data stripe, and transmits a locking request to each first RAID data storage device. When the second RAID data storage device receives a locking confirmation that indicates that each first RAID data storage device is locked, it completes the data update operation on the subset of data included in the data stripe. The second RAID data storage device then transmits an unlocking request to each first RAID data storage device to cause them to unlock, and transmits a completion communication that indicates that the data update operation has been performed.

Abstract: Embodiments disclosed herein relate scaffolds containing fluoridated apatites sintered at a temperature of at least 950° C. to increase integration of the scaffold in a patient, as well as methods of making and using the same.

Abstract: Various embodiments provide an optical lens that includes wafer level diffractive microstructures. In one embodiment, the optical lens includes a substrate, a microstructure layer having a first refractive index, and a protective layer having a second refractive index that is different from the first refractive index. The microstructure layer is formed on the substrate and includes a plurality of diffractive microstructures. The protective layer is formed on the diffractive microstructures. The protective layer provides a cleanable surface and encapsulates the diffractive microstructures to prevent damage and contamination to the diffractive microstructures. In another embodiment, the optical lens includes a substrate and an anti-reflective layer. The anti-reflective layer is formed on the substrate and includes a plurality of diffractive microstructures.

Abstract: A vehicle comprising a passenger cabin and an air conditioning system is disclosed. The air conditioning system comprises a Peltier device, a first blower for directing a first airflow over a first side of the Peltier device, and a second blower for directing a second airflow over a second side of the Peltier device. The second blower draws the second airflow from inside the passenger cabin, and the second airflow is discharged to outside the passenger cabin.

Abstract: A vehicle comprising, a passenger cabin, a door to the passenger cabin, and an air conditioning system is disclosed. The air conditioning system comprise a Peltier device, a blower for directing an airflow over a first side of the Peltier device and ducting for ducting air to the blower, the ducting comprising an inlet located on an underside of the door.

Abstract: A RAID data storage device multi-step command coordination system includes a RAID storage controller device that generates and transmits a first multi-step command that includes a barrier instruction, and a second multi-step command that includes a notification instruction. A first RAID data storage device receives the first multi-step command, identifies the barrier instruction in the first multi-step command and, in response, pauses performance of first multi-step command. A second RAID data storage device receives the second multi-step command, identifies the notification instruction in the second multi-step command and, in response, transmits a notification to the first RAID data storage device. While pausing the performance of the first multi-step command, the first RAID data storage device determines that the notification has been received and, in response, resumes the performance of the first multi-step command.

Abstract: There is provided a method of computing resource allocation. The method comprises allocating a first bounded amount of computing resources forming a first set of computing resources; exclusively assigning the first set of computing resources to a first process of a computer program; receiving a request from the first process for additional computing resources; in response to the request from the first process, allocating a second bounded amount of computing resources forming a second set of computing resources; and spawning a second process from the first process and exclusively assigning the second set of computing resources to the second process; wherein this method may be repeated indefinitely by the first process, second process, or any other process created according to this method. By following this method, a process does not control the amount of computing resources allocated to that process (i.e., itself), but instead controls the amount of computing resources allocated to its child processes.