Patents by Inventor James R. Baker, Jr.

James R. Baker, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200197511
    Abstract: The present application relates to the field of human immunology, in particular, a herpes simplex virus (HSV) vaccine. The subunit vaccine composition comprises isolated surface glycoproteins from herpes simplex viruses, fusion proteins or fragments thereof mixed in varied combination with a nanoemulsion, which is a potent immune enhancer.
    Type: Application
    Filed: November 15, 2018
    Publication date: June 25, 2020
    Applicant: NanoBio Corporation
    Inventors: Ali I. FATTOM, Jakub Simon, James R. Baker, JR., Tarek Hamouda, Vira Bitko
  • Patent number: 10596251
    Abstract: The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: March 24, 2020
    Assignee: NanoBio Corporation
    Inventors: Ali I. Fattom, Tarek Hamouda, Vira Bitko, James R. Baker, Jr.
  • Patent number: 10525121
    Abstract: The present invention relates to methods for inducing an immune response to influenza in a subject comprising administering a nanoemulsion vaccine composition comprising an influenza immunogen or protein.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: January 7, 2020
    Assignee: NanoBio Corporation
    Inventors: Tarek Hamouda, Joyce A. Sutcliffe, James R. Baker, Jr.
  • Publication number: 20190282693
    Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the invention provides methods and compositions for enhancing an immune response to one or more antigens. Compositions and methods of the invention are useful for the treatment and/or prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites, as well as the treatment and/or prevention of cancer and malignant diseases. Compositions and methods of the invention include one or more antigens/immunogens together with an adjuvant formulation comprising an emulsion delivery system in combination with one or more immunostimulatory compounds (e.g., a compound that stimulates the innate immune system (e.g., a toll-like receptor antagonist (e.g., synthetic oligodeoxynucleotides (ODN)))) that enhance immune responses to the one or more antigens/immunogens when administered to a subject.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 19, 2019
    Inventors: James R. Baker, Jr., Douglas M. Smith, Susan Ciotti
  • Publication number: 20190083606
    Abstract: The present application relates to the field of human immunology, in particular, a herpes simplex virus (HSV) vaccine. The subunit vaccine composition comprises isolated surface glycoproteins from herpes simplex viruses, fusion proteins or fragments thereof mixed in varied combination with a nanoemulsion, which is a potent immune enhancer.
    Type: Application
    Filed: November 15, 2018
    Publication date: March 21, 2019
    Applicant: NanoBio Corporation
    Inventors: Ali I. FATTOM, Jakub Simon, James R. Baker, JR., Tarek Hamouda, Vira Bitko
  • Patent number: 10206996
    Abstract: The present application relates to the field of human immunology, in particular, a herpes simplex virus (HSV) vaccine. The subunit vaccine composition comprises isolated surface glycoproteins from herpes simplex viruses, fusion proteins or fragments thereof mixed in varied combination with a nanoemulsion, which is a potent immune enhancer.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: February 19, 2019
    Assignee: NanoBio Corporation
    Inventors: Ali I. Fattom, Jakub Simon, James R. Baker, Jr., Tarek Hamouda, Vira Bitko
  • Publication number: 20190022200
    Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
    Type: Application
    Filed: May 21, 2018
    Publication date: January 24, 2019
    Inventors: Andrzej Myc, Ilona Kryczek, James R. Baker, JR.
  • Patent number: 10138279
    Abstract: The present invention relates to methods and compositions for stimulating an immune response. Specifically, the present invention provides methods of inducing an immune response to bacteria of the genus Bacillus (e.g., Bacillus anthracis) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising Bacillus anthracis or an immunogenic portion thereof). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination) and research applications.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: November 27, 2018
    Assignee: Regents of the University of Michigan
    Inventors: James R. Baker, Jr., Anna Bielinska, Andrzej Myc
  • Patent number: 9974844
    Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: May 22, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Andrzej Myc, Ilona Kryczek, James R. Baker, Jr.
  • Publication number: 20170360919
    Abstract: The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.
    Type: Application
    Filed: January 27, 2017
    Publication date: December 21, 2017
    Applicant: NanoBio Corporation
    Inventors: Ali I. Fattom, Tarek Hamouda, Vira Bitko, James R. Baker, JR.
  • Patent number: 9839685
    Abstract: The present invention relates to methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods of inducing an immune response to human immunodeficiency virus (HIV) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising HIV or antigenic portion thereof).
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: December 12, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James R. Baker, Jr., Anna Bielinska, Andrzej Myc
  • Patent number: 9801842
    Abstract: The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: October 31, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James R. Baker, Jr., Sivaprakash Rathinavelu, Paul E. Makidon, John J. LiPuma, Shraddha Nigavekar
  • Publication number: 20170246294
    Abstract: The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
    Type: Application
    Filed: October 9, 2015
    Publication date: August 31, 2017
    Inventors: James R. BAKER, JR., Anna U. BIELINSKA, Douglas SMITH, Paul E. MAKIDON, Jessica J. O'KONEK
  • Patent number: 9561271
    Abstract: The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: February 7, 2017
    Assignee: NanoBio Corporation
    Inventors: Ali I. Fattom, Tarek Hamouda, Vira Bitko, James R. Baker, Jr.
  • Patent number: 9492525
    Abstract: The present invention relates to RSV vaccines and methods for inducing an immune response to RSV in a subject comprising administering an RSV vaccine.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: November 15, 2016
    Assignee: NANOBIO CORPORATION
    Inventors: Ali I. Fattom, Nicolas Lukacs, James R. Baker, Jr., Vira Bitko, Tarek Hamouda
  • Patent number: 9415006
    Abstract: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides immunogenic compositions and methods of using the same to induce immune responses (e.g., immunity (e.g., protective immunity)) against Hepatitis B virus (HBV)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: August 16, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James R. Baker, Jr., Anna U. Bielinska, Nicholas Mank, Paul E. Makidon, Zhengyi Cao, Alison J Scott, Shraddha S. Nigavekar
  • Patent number: 9402911
    Abstract: The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of use of the same.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: August 2, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James R. Baker, Jr., Baohua M. Huang, Thommey P. Thomas
  • Publication number: 20160158179
    Abstract: The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
    Type: Application
    Filed: February 11, 2016
    Publication date: June 9, 2016
    Inventors: James R. Baker, Jr., Mark R. Hemmila, Stewart C. Wang, Tarek Hamouda, John J. LiPuma, Jessica Ann Knowlton, Paul E. Makidon, Luz Blanco, Jeffery V. Groom, II, Anna U. Bielinska
  • Publication number: 20160074504
    Abstract: The present invention relates to methods for inducing an immune response to influenza in a subject comprising administering a nanoemulsion vaccine composition comprising an influenza immunogen or protein.
    Type: Application
    Filed: September 24, 2015
    Publication date: March 17, 2016
    Applicant: NanoBio Corporation
    Inventors: Tarek Hamouda, Joyce A. Sutcliffe, James R. Baker, JR.
  • Patent number: 9259407
    Abstract: The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: February 16, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James R. Baker, Jr., Mark R. Hemmila, Stewart C. Wang, Tarek Hamouda, John J. LiPuma, Jessica Ann Knowlton, Paul E. Makidon, Luz Blanco, Jeffery V. Groom, II, Anna U. Bielinska