Patents by Inventor James R. Baker, Jr.
James R. Baker, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9017644Abstract: The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).Type: GrantFiled: November 9, 2009Date of Patent: April 28, 2015Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Larry A. Sternson, David Repp, Deborah Ladenheim
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Patent number: 8980907Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.Type: GrantFiled: December 16, 2013Date of Patent: March 17, 2015Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Xue-min Cheng, Abraham F. L. Van Der Spek, Baohua Mark Huang, Thommey P. Thomas
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Patent number: 8962026Abstract: The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.Type: GrantFiled: September 25, 2009Date of Patent: February 24, 2015Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Mark R. Hemmila, Stewart C. Wang, Tarek Hamouda, John J. LiPuma, Jessica A. Knowlton, Paul E. Makidon, Luz P. Blanco, Jeffery V. Groom, II, Anna U. Bielinska
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Publication number: 20150050318Abstract: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods of inducing an immune response against one or a plurality of pathogens (e.g., vaccinia virus, H5N1 influenza virus, Bacillus anthracis, C. botulinum, Y. pestis, Hepatits B, and/or HIV, etc.) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., immunogenic composition comprising nanoemulsion and one or a plurality of pathogens (e.g., inactivated by the nanoemulsion) and/or pathogen products and/or pathogen components). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g.Type: ApplicationFiled: November 4, 2014Publication date: February 19, 2015Inventors: James R. Baker, JR., Anna U. Bielinska, Nicholas J. Mank, Paul E. Makidon, Jessica A. Knowlton, Luz P. Blanco
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Patent number: 8945508Abstract: The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))).Type: GrantFiled: October 7, 2010Date of Patent: February 3, 2015Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Baohua Huang
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Patent number: 8912323Abstract: The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same.Type: GrantFiled: September 30, 2010Date of Patent: December 16, 2014Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Hong Zong, Thommey P. Thomas
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Patent number: 8889635Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.Type: GrantFiled: September 30, 2009Date of Patent: November 18, 2014Assignee: The Regents of The University of MichiganInventors: James R. Baker, Jr., Xue-min Cheng, Abraham F. L. Van Der Spek, Baohua Mark Huang, Thommey P. Thomas
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Patent number: 8877208Abstract: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods of inducing an immune response against one or a plurality of pathogens (e.g., vaccinia virus, H5N1 influenza virus, Bacillus anthracis, C. botulinum, Y. pestis, Hepatitis B, and/or HIV, etc.) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., immunogenic composition comprising nanoemulsion and one or a plurality of pathogens (e.g., inactivated by the nanoemulsion) and/or pathogen products and/or pathogen components). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: GrantFiled: May 26, 2009Date of Patent: November 4, 2014Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Paul E. Makidon, Nicholas J. Mank, Anna U. Bielinska, Luz P. Blanco, Jessica Knowlton
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Publication number: 20140303123Abstract: The present invention relates to compositions (e.g., dendrimer scaffolds) capable of click chemistry for use in synthesis of functionalized dendrimers within biological settings, and methods of use of the same.Type: ApplicationFiled: November 15, 2012Publication date: October 9, 2014Inventors: James R. Baker, JR., Sascha Nilu Goonewardena, Hong Zong
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Patent number: 8853151Abstract: The present invention provides methods, compositions and applications for efficient, site-specific drug delivery using pro-drug complexes comprising one or more functional groups (e.g., imaging agents, targeting agents, and trigger agents) conjugated with a therapeutic agent (e.g., a chemotherapeutic agent), methods of synthesizing the same, as well as systems and methods utilizing the therapeutic and diagnostic compositions (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, etc.))). Trigger agents include an indolequinone; attachment groups include a triazole ring; and therapeutic agents include camptothecin.Type: GrantFiled: June 30, 2010Date of Patent: October 7, 2014Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Baohua M. Huang, Thommey P. Thomas
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Publication number: 20140294733Abstract: The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of use of the same.Type: ApplicationFiled: November 20, 2012Publication date: October 2, 2014Inventors: James R. Baker, JR., Baohua M. Huang, Thommey P. Thomas
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Publication number: 20140287047Abstract: The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.Type: ApplicationFiled: June 9, 2014Publication date: September 25, 2014Inventors: James R. Baker, JR., Sivaprakash Rathinavelu, Paul E. Makidon, John J. LiPuma, Shraddha Nigavekar
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Publication number: 20140193461Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against a bacterial species of the genus Streptococcus (e.g., Streptococcus pneumoniae))). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: ApplicationFiled: March 10, 2014Publication date: July 10, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, JR., Paul E. Makidon, Whitney A. Dunlap, Jessica A. Knowlton, Benjamin Swanson
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Patent number: 8771731Abstract: The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.Type: GrantFiled: August 18, 2006Date of Patent: July 8, 2014Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Tarek Hamouda, Amy Shih, Andrzej Myc
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Publication number: 20140128327Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.Type: ApplicationFiled: December 16, 2013Publication date: May 8, 2014Applicant: The Regents of the University of MichiganInventors: James R. Baker, JR., Xue-min Cheng, Abraham F.L. Van Der Spek, Baohua Mark Huang, Thommey P. Thomas
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Publication number: 20140093537Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of administering the same (e.g., via a heterologous prime/boost protocol (e.g., utilizing the same nanoemulsion in each the prime and boost administrations)) to induce immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: ApplicationFiled: September 30, 2013Publication date: April 3, 2014Applicants: NANOBIO CORPORATION, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James R. Baker, JR., Douglas Smith, Ali I. Fattom, Jakub Simon
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Patent number: 8668911Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against a bacterial species of the genus Streptococcus (e.g., Streptococcus pneumoniae))). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.Type: GrantFiled: May 14, 2010Date of Patent: March 11, 2014Assignee: The Regents Of The University Of MichiganInventors: James R. Baker, Jr., Paul E. Makidon, Whitney A. Dunlap, Jessica A. Knowlton, Benjamin Swanson
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Publication number: 20130273113Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., immunologic cell death/apoptosis (e.g., for the induction of innate and/or adaptive immune responses)). Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., for infectious disease, cancer, autoimmunity, and/or tissue injury (e.g., via alteration of host immune responses))) and research applications.Type: ApplicationFiled: March 15, 2013Publication date: October 17, 2013Applicant: The Regents of the University of MichiganInventors: James R. Baker, JR., Paul Makidon, Andrzej Myc
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Patent number: 8497992Abstract: A system for determining whether interaction occurs between a trial substance and a target substance. The system includes a photonic crystal sensor having a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface able to receive the target substance and the trial substance. The system further includes a light source that inputs a light signal to the photonic crystal structure and the defect member. The light signal is internally reflected, and a resultant output signal is outputted. The output signal relates to whether the trial substance interacts with the target substance at the operative surface. Furthermore, the system includes an identity detector that identifies the trial substance that interacts with the target substance.Type: GrantFiled: November 11, 2009Date of Patent: July 30, 2013Assignee: The Regents of The University of MichiganInventors: Jingyong Ye, Jason E. Gestwicki, Theodore B. Norris, James R. Baker, Jr., Tommaso F. Bersano-Begey
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Patent number: 8445528Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.Type: GrantFiled: July 12, 2012Date of Patent: May 21, 2013Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., Xue-min Cheng, Thommey P. Thomas, Baohua Mark Huang